A5083619500- Inflammatory Bowel Disease
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Microscopic Colitis
- Prostate Cancer Treatment and Research
- Head and Neck Cancer Studies
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Pancreatitis Pathology and Treatment
- Gut microbiota and health
- Molecular Biology Techniques and Applications
- Immunotherapy and Immune Responses
- Metastasis and carcinoma case studies
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Ubiquitin and proteasome pathways
- Colorectal Cancer Screening and Detection
- Antimicrobial Peptides and Activities
- Phytoestrogen effects and research
- Inflammatory Biomarkers in Disease Prognosis
- Infant Nutrition and Health
- Effects and risks of endocrine disrupting chemicals
- Salivary Gland Disorders and Functions
Meharry Medical College
2015-2025
Nashville Oncology Associates
2014-2020
Charles R. Drew University of Medicine and Science
2018
Institute of Cell Biology and Neurobiology
2014
Vanderbilt University
2004-2012
Geriatric Research Education and Clinical Center
2004
The University of Texas Health Science Center at San Antonio
2004
Murphy Oil Corporation (United States)
2004
South Texas Veterans Health Care System
2004
University at Buffalo, State University of New York
1978
Oxidative stress has been suggested to potentiate atherogenesis. However, studies that have investigated the effect of antioxidants on atherosclerosis showed inconsistent results, ie, was either retarded or not changed by dietary antioxidants. This report directly examined overexpressing Cu/Zn-superoxide dismutase (Cu/Zn-SOD) and/or catalase and lipid peroxidation in mice lacking apolipoprotein E ( ApoE −/− ). Based staining en face aorta tree serial sections proximal aorta, both Cu/Zn-SOD...
The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that belongs to the basic-helix-loop-helix (bHLH)-Per-ARNT-Sim (PAS) superfamily of factors, mediates toxic response induced by environmental chemicals such as polycyclic aromatic hydrocarbons (PAH). AhR is expressed at high levels in several human breast carcinoma cell lines direct correlation with degree their malignancy. Recent studies suggest possible role for cancer independent PAH. Therefore, we established...
Aberrant elevation of JARID1B and histone H3 lysine 4 trimethylation (H3K4me3) is frequently observed in many diseases including prostate cancer (PCa), yet the mechanisms on regulation H3K4me3 through epigenetic alterations still remain poorly understood. Here we report that Skp2 modulates levels vitro cultured cells vivo mouse models. We demonstrated inactivation decreased levels, along with a reduction cell growth, migration malignant transformation Pten/Trp53 double null MEFs, further...
Abstract KDM5B (lysine[K]-specific demethylase 5B) is frequently upregulated in various human cancers including prostate cancer. controls H3K4me3/2 levels and regulates gene transcription cell differentiation, yet the contributions of to cancer tumorigenesis remain unknown. In this study, we investigated functional role epigenetic dysregulation progression cultured cells mouse models epithelium–specific mutant Pten/Kdm5b. Kdm5b deficiency resulted a significant delay onset Pten-null mice,...
The aberrant expression of α defensin 5 (DEFA5) protein in colonic inflammatory bowel diseases (IBDs) underlies the distinct pathogenesis Crohn's colitis (CC). It can serve as a biomarker for differentiating CC from Ulcerative (UC), particularly Indeterminate (IC) cases into UC and CC. We evaluated specificity commercially available anti-DEFA5 antibodies, emphasizing need to further validate their appropriateness given application highlighting necessity novel antibodies. established two mice...
The incidence of familial adenomatous polyposis (FAP) is one in 7,000 to 12,000 live births. Virtually, all surgically untreated patients with FAP inevitably develop colorectal-cancer their lifetime because they carry the coli gene. Thus prophylactic proctocolectomy indicated. Surgical treatment still controversial. There are however, four surgical options: ileorectal anastomosis, restorative ileal pouch-anal ileostomy, and continent-ileostomy. Conventional options largely lie between...
Recent studies suggest that bone marrow stem cells (BMSCs) are promising grafts to treat a variety of diseases, including reproductive dysfunction. Primary ovarian failure is characterized by amenorrhea and infertility in normal karyotype female, with an elevated serum level follicle-stimulating hormone (FSH) decrease estrogen caused mutation FSH receptor (FSHR) gene. Currently, there no effective treatment for this condition. The phenotype FSHR (−/−) mouse, FORKO (follitropin knockout),...
The binding of IL-18 to IL-18Rα induces both proinflammatory and protective functions during infection, depending on the context in which it occurs. is highly expressed liver wild-type (WT) C57BL/6 mice following lethal infection with virulent Ixodes ovatus ehrlichia (IOE), an obligate intracellular bacterium that causes acute fatal toxic shock-like syndrome. In this study, we found IOE IL-18Rα(-/-) resulted significantly less host cell apoptosis, decreased hepatic leukocyte recruitment,...
A homozygous missense mutation, C566T, in the follicle stimulation hormone receptor (FSHR) gene has been linked to premature ovarian failure. The disease leads infertility a normal karyotype female with an elevated stimulating (FSH) and decreased serum estrogen level. Female mice carrying mutated FSHR gene, called follitropin knockout (FORKO), display similar phenotype are sterile because of folliculogenesis block at primary stage. We investigated effects bilateral intra-ovarian injection...
Individuals with a heterozygous mutation at the ataxia-telangiectasia mutated gene (ATM) have been reported to be predisposed ischemic heart disease. This report examined for first time effect of ATM (ATM+/−) on plasma lipid levels and atherosclerosis intensity using ATM+/−, ATM+/+ (wild type), ATM+/+/LDLR−/− (low density lipoprotein receptor knockout), ATM+/−/LDLR−/−, ATM+/+/ApoE−/− (apolipoprotein E ATM+/−/ApoE−/− mice. Our data demonstrated that cholesterol triglyceride in ATM+/−...
Inability to distinguish Crohn's colitis from ulcerative leads the diagnosis of indeterminate colitis. This greatly effects medical and surgical care patient because treatments for two diseases vary. Approximately 30 percent inflammatory bowel disease patients cannot be accurately diagnosed, increasing their risk inappropriate treatment. We sought determine whether transcriptomic patterns could used develop diagnostic biomarker(s) delineate more accurately. Four groups were assessed via...
// Yin Ye 1 , Justin Wang 2 Michael G. Izban Billy R. Ballard and Sanford H. Barsky Department of Pathology, Anatomy Cell Biology the Clinical Translational Research Center Excellence, Meharry Medical College, Nashville, TN 37208, USA Graduate Education, Scripps Mercy Hospital, San Diego, CA 92103, Correspondence to: Barsky, email: sbarsky@mmc.edu Keywords: dormancy; lymphovascular embolus; mTOR; E-cadherin proteolysis Received: June 13, 2024 Accepted: September 17, Published: October 11,...
Spindle cell carcinoma (SpCC) or sarcomatoid is a highly malignant variant of squamous which comprises 2% to 3% all laryngeal cancers. It considered be biphasic tumor that composed (in situ invasive) and spindle with sarcomatous appearance. Most tumors are polypoid pedunculated; they often detected at an early stage, removed by polypectomy during diagnosis, tend have very good prognosis. We present case in 67-year-old Caucasian male who presented progressive hoarseness his voice, dysphagia,...
Evidence link bacterial enterotoxins to apparent crypt-cell like cells (CCLCs), and Alpha Defensin 5 ( DEFA5 ) expansion in the colonic mucosa of Crohn’s colitis disease (CC) patients. These areas ectopic ileal metaplasia, positive for Paneth cell (PC) markers are consistent with diagnosis CC. Retrospectively, we: 1. Identified 21 patients indeterminate (IC) between 2000–2007 were reevaluation their final clinical 2014 after a followed-up mean 8.7±3.7 (range, 4–14) years. Their initial...
Changes in FOXA1 (forkhead box protein A1) levels are well associated with prostate cancer (PCa) progression. Unfortunately, direct targeting of progressive PCa remains challenging due to variations levels, increased mutations at different stages PCa, and elusive post‐translational regulating mechanisms. Here, we show that SKP2 (S‐phase kinase‐associated 2) catalyzes K6‐ K29‐linked polyubiquitination for lysosomal‐dependent degradation. Our data indicate SKP2:FOXA1 ratios stage IV human...
UPLC-IM-MS/MS analysis of human breast tissue extracts distinguished cancerous and non-cancerous diseases by characteristic molecular signatures.