A5071344458- Inflammatory Bowel Disease
- Microscopic Colitis
- Genetic factors in colorectal cancer
- Gut microbiota and health
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Treatments and Studies
- Helicobacter pylori-related gastroenterology studies
- Tuberculosis Research and Epidemiology
- Immunotherapy and Immune Responses
- Colorectal Cancer Surgical Treatments
- Antimicrobial Peptides and Activities
- Diverticular Disease and Complications
- Gastrointestinal motility and disorders
- Inflammatory Biomarkers in Disease Prognosis
- Eosinophilic Esophagitis
- Nutrition and Health in Aging
- Infant Nutrition and Health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Autoimmune and Inflammatory Disorders
- Gastric Cancer Management and Outcomes
- Erythrocyte Function and Pathophysiology
- Prostate Cancer Treatment and Research
- Neonatal Health and Biochemistry
- Digestive system and related health
- Clusterin in disease pathology
Meharry Medical College
2015-2025
Vanderbilt University Medical Center
2006-2025
AdventHealth Tampa
2024
Vanderbilt University
2012-2023
American Society of Colon and Rectal Surgeons
2018-2023
American Gastroenterological Association
2018-2023
Tennessee Oncology
2023
Centre for Cancer Biology
2023
Colon and Rectal Surgery Associates
2015
Creative Research Enterprises (United States)
2014
As accessible diagnostic approaches fail to differentiate between ulcerative colitis (UC) and Crohn's (CC) in one-third of patients with predominantly colonic inflammatory bowel disease (IBD), leading inappropriate therapy, we aim investigate the serum cytokine levels these search molecular biometric markers delineating UC from CC. We measured 38 cytokines, chemokines, growth factors using magnetic-bead-based multiplex immunoassay 25 patients, 28 CC 30 controls. Our results are compared...
The aberrant expression of α defensin 5 (DEFA5) protein in colonic inflammatory bowel diseases (IBDs) underlies the distinct pathogenesis Crohn's colitis (CC). It can serve as a biomarker for differentiating CC from Ulcerative (UC), particularly Indeterminate (IC) cases into UC and CC. We evaluated specificity commercially available anti-DEFA5 antibodies, emphasizing need to further validate their appropriateness given application highlighting necessity novel antibodies. established two mice...
Differentiating ulcerative colitis (UC) from Crohn's (CC) can be difficult and may lead to inaccurate diagnoses in up 30% of inflammatory bowel disease (IBD) patients. Much the diagnostic uncertainty arises overlap clinical histologic features. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) permits a histology-directed cellular protein analysis tissues. As pilot study, we evaluated ability MALDI-MS determine proteomic patterns for potential differences between CC UC...
Although Crohn's colitis (CC) and ulcerative (UC) share several clinical features, they have different causes, mechanisms of tissue damage, treatment options. Therefore, the accurate diagnosis is paramount importance in terms medical care. The distinction between CC/UC made on basis clinical, radiologic, endoscopic, pathologic interpretations but cannot be differentiated up to 15% inflammatory bowel disease patients. Correct management this "indeterminate colitis" depends accuracy future,...
The incidence of familial adenomatous polyposis (FAP) is one in 7,000 to 12,000 live births. Virtually, all surgically untreated patients with FAP inevitably develop colorectal-cancer their lifetime because they carry the coli gene. Thus prophylactic proctocolectomy indicated. Surgical treatment still controversial. There are however, four surgical options: ileorectal anastomosis, restorative ileal pouch-anal ileostomy, and continent-ileostomy. Conventional options largely lie between...
Inflammatory bowel disease has an enormous impact on public health, medical systems, economies, and social conditions. Biologic therapy ameliorated the treatment clinical course of patients with inflammatory disease. The efficacy safety profiles currently available therapies are still less that optimal in numerous ways, highlighting requirement for new therapeutic targets. A bunch drug studies underway promising results. This is outlined guideline diagnosis pharmaceutical Outline delineates...
Abstract Purpose: Stratifying patients who have a high risk of prostate cancer recurrence following prostatectomy can potentiate the use adjuvant therapy at an early stage. Inflammation has emerged as mediator metastatic progression. We hypothesized that chemokines be biomarkers for distinguishing with biochemical cancer. Experimental Design: In nested case-control study, 82 subjects developed within 5 years prostatectomy. Prostate tissues from 98 age-matched were recurrence-free in same...
Obesity is associated with excess lipid deposition in muscles, which considered as a leading cause of metabolic dysfunction and oxidative stress. Cellular uptake lipids regulated by several membrane receptors, among the very low-density lipoprotein receptor (VLDLR). This article provides information on role VLDLR cardiac muscle how its expression regulates insulin resistance stress obese mouse model.
The gastrointestinal system where inflammatory bowel disease occurs is central to the immune innate and adaptive/acquired systems are balanced in interactions with gut microbes under homeostasis conditions. This article overviews high-throughput research screening on multifactorial interplay between genetic risk factors, intestinal microbiota, urbanization, modernization, Westernization, environmental influences responses etiopathogenesis of humans. Inflammatory an expensive debilitating...
Inability to distinguish Crohn's colitis from ulcerative leads the diagnosis of indeterminate colitis. This greatly effects medical and surgical care patient because treatments for two diseases vary. Approximately 30 percent inflammatory bowel disease patients cannot be accurately diagnosed, increasing their risk inappropriate treatment. We sought determine whether transcriptomic patterns could used develop diagnostic biomarker(s) delineate more accurately. Four groups were assessed via...
PURPOSE: This study was designed to investigate the development of anemia during functional ileoanal pouch. METHODS: Eighty-three patients received an pouch between 1980 and 1987. The hematology data deviations among preoperative period, defunctionalized stage, after ileal in function were monitored. Aspects studied included serum hemoglobin, iron, folates, vitamin B12, white blood cell, erythrocyte sedimentation rate, pt-B12, fat absorption. Specimens collected before colectomy, ileostomy...
We analyzed inflamed mucosal/submucosal layers of ulcerative colitis (UC = 63) and Crohn's (CC 50), unexpectedly, we unveiled a pool free hemoglobin alpha (Hb-α) chain. Patients with colitides have increased reactive oxidative stress (ROS), DNA oxidation products, iron in mucosa, preneoplastic, colitis-cancers risks developing colorectal cancer. All inflammatory bowel disease-related cancer lesions are found segments colitis. Linking this information, investigated whether Hb-α is key...
Crohn disease (CD) and ulcerative colitis (UC), known collectively as inflammatory bowel diseases (IBDs), are chronic immunoinflammatory pathologies of unknown aetiology. Despite the frequent use biomarkers in medical practice, there is a relative lack information regarding validated paediatric for IBD. Furthermore, proved to be efficacious adults frequently extrapolated clinical setting without considering that pathogenesis many distinctly different children. In present study, proteomics...
Background and Aims: Gut smooth muscle dysfunctions contribute to symptoms such as abdominal cramping, diarrhea, constipation in inflammatory bowel disease (IBD). The mechanisms for are incompletely understood. We tested the hypothesis that mechanical stress plays a role dysfunction rat model of Crohn’s-like colitis where stenosis leads distention pre-inflammation site. Methods: was induced by intracolonic instillation TNBS (65 mg/kg) Sprague-Dawley rats. Control rats were instilled with...
Evidence link bacterial enterotoxins to apparent crypt-cell like cells (CCLCs), and Alpha Defensin 5 ( DEFA5 ) expansion in the colonic mucosa of Crohn’s colitis disease (CC) patients. These areas ectopic ileal metaplasia, positive for Paneth cell (PC) markers are consistent with diagnosis CC. Retrospectively, we: 1. Identified 21 patients indeterminate (IC) between 2000–2007 were reevaluation their final clinical 2014 after a followed-up mean 8.7±3.7 (range, 4–14) years. Their initial...