A5079896387- Radiomics and Machine Learning in Medical Imaging
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Urinary and Genital Oncology Studies
- Congenital Diaphragmatic Hernia Studies
- Amino Acid Enzymes and Metabolism
- Urological Disorders and Treatments
- AI in cancer detection
- Tissue Engineering and Regenerative Medicine
- Hematopoietic Stem Cell Transplantation
- Hedgehog Signaling Pathway Studies
- Esophageal Cancer Research and Treatment
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Prostate Cancer Diagnosis and Treatment
- Polyamine Metabolism and Applications
- Breast Cancer Treatment Studies
- Renal and related cancers
Icahn School of Medicine at Mount Sinai
2014-2023
Columbia University Irving Medical Center
2011-2021
Mount Sinai Health System
2015
Mount Sinai Medical Center
2015
Columbia University
2012
Cre-loxp mediated conditional knockout strategy has played critical roles for revealing functions of many genes essential development, as well the causal relationships between gene mutations and diseases in postnatal adult mice. One key factor this is availability mice with tissue- or cell type-specific Cre expression. However, success traditional molecular cloning approach to generate tissue specific expression often depends on luck. Here we provide a better alternative by using bacterial...
Background : PreciseDx Breast is a digital test that predicts early-stage breast cancer recurrence within 6-years of diagnosis. Materials and Methods Using hematoxylin eosin-stained whole slide images invasive (IBC) artificial intelligence-enabled Morphology Feature Array, microanatomic features are generated. Morphometric attributes in combination with patient age, tumor size, stage lymph node status disease free survival using proprietary algorithm. Here, analytical validation the...
You have accessJournal of UrologyUrothelial Cancer: Natural History & Pathophysiology/Marker1 Apr 2012385 DELTAN P63 (ΔNP63) EXPRESSION AS A PROGNOSTIC FACTOR OF PROGRESSION IN CLINICAL HGT1 BLADDER CANCER Josep Maria Gaya, Mireia Castillo-Martin, Juan Manuel Lopez-Martinez, Orit Karni-Schmidt, Nataliya Gladoun, Ferran Algaba, Joan Palou, Humberto Villavicencio, Mitchell C. Benson, and Carlos Cordon-Cardo GayaJosep Gaya New York City, NY More articles by this author , Castillo-MartinMireia...
Abstract Background. Non-Muscle Invasive Bladder Cancer (NMIBC) represents a heterogeneous disease with very different outcomes depending on progression to muscle invasive (MID). NMIBC is one of the major causes malignancy-related morbidity and mortality worldwide it ninth most costly cancer in United States terms overall expenditures. Even though some clinical molecular risk factors have been reported predict progression, they shown limited prognostic ability setting define which patients...
345 Background: Bladder cancer is a rare entity in the pediatric population making it difficult to define surveillance protocols and long term outcomes. Notably, most tumors are low grade non-muscle invasive do not recur. In order determine source of different natural history between adults, we hypothesized that bladder may potentially stem from molecular pathways than its adult form. Our main objective was study pathogenesis this disease using immunohistochemical (IHC) mutational analysis...
47 Background: We have previously validated the importance of utilizing intact tissue section and quantitative biomarker strategies for developing prognostic prostate cancer outcome models. sought to further expand upon these constructs by applying next-gen advanced image analysis tools using multiplex immunofluorescence (IF) integrated with clinical variables on an independent cohort. Methods: Utilizing a 686 patient radical prostatectomy microarray population median 8 years follow-up from...
On the Cover: Systemic hemoglobin exposure triggers blood-brain barrier (BBB) disruption and oxidative stress.Brain sections of guinea pigs transfused with polymerized cell-free were immunostained for markers stress (HO-1, green) BBB dysfunction (GFAP, red); nuclei counterstained Hoechst 33342 (blue).HO-1-positive pericytes/perivascular macrophages (green) are shown lining walls vessels diffuse enhanced GFAP reactivity.Original magnification, ϫ400.(See page 1316.
236 Background: Quantitative analysis of formalin-fixed paraffin-embedded (FFPE) prostate samples post radical-prostatectomy (RP) can help guide management post-operative cancer (PCa) patients. We have previously published on the results our systems (precise) pathology platform which includes integration clinical data with immunofluorescent (IF) morphology and biomarkers to predict disease progression in post-RP extended this approach by developing quantitative image features that further...
Abstract Background: Postoperative risk assessment remains an important variable in the treatment of prostate cancer. We aimed to develop and validate a tissue-based on-slide prognostic model test identify which patients would benefit most from early intervention. Methods: Prospectively designed retrospective study utilizing 892 patients, post radical prostatectomy, followed for median 8 years. constructed matched 50:50 training cohort compound features using protein multiplex...
The last several years have witnessed renewed interest regarding the contribution of cancer stem cells in tumorigenesis and neoplastic heterogeneity. It has been reported that patients who undergo bone marrow transplantation are more prone to develop a malignancy during their life time; usually hematological tumors, but solid neoplasms may also develop, which certain instances donor-derived. well documented multipotent derived can migrate diverse organs, differentiating into various...