A5044289956- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Acute Kidney Injury Research
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- COVID-19 Clinical Research Studies
- Organ Donation and Transplantation
- Hemodynamic Monitoring and Therapy
- Electrolyte and hormonal disorders
- Liver Disease Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Anesthesia and Sedative Agents
- COVID-19 and healthcare impacts
- Cardiac Structural Anomalies and Repair
- Dermatological and COVID-19 studies
- Anesthesia and Neurotoxicity Research
- Chronic Kidney Disease and Diabetes
- Transplantation: Methods and Outcomes
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Renal function and acid-base balance
- Muscle and Compartmental Disorders
- Peptidase Inhibition and Analysis
Columbia University Irving Medical Center
2012-2025
Columbia University
2015-2024
Association Clinique et Thérapeutique Infantile du Val de Marne
2023
Presbyterian Hospital
2022
NewYork–Presbyterian Hospital
2006-2022
New York Hospital Queens
2022
Penn State Milton S. Hershey Medical Center
2020
Bridge University
2020
University of Colorado Anschutz Medical Campus
2020
New York Proton Center
2020
Acute renal dysfunction (ARD) and subsequent acute failure after cardiac surgery are associated with high mortality morbidity. Early therapeutic or preventive intervention is hampered by the lack of an early biomarker for injury. Recent studies showed that urinary neutrophil gelatinase-associated lipocalin (NGAL 2) up-regulated (within 1-3 h) murine injury in pediatric ARD surgery. The authors hypothesized postoperative NGAL concentrations increased adult patients developing compared without...
Serum creatinine (Scr) does not allow for early diagnosis of acute kidney injury (AKI). The diagnostic utility urinary molecule-1 (KIM-1), N-acetyl-beta-D-glucosaminidase (NAG), and neutrophil gelatinase associated lipocalin (NGAL) was evaluated the detection postoperative AKI in a prospective study 90 adults undergoing cardiac surgery. Designs, setting, participants, & measurements: Urinary KIM-1, NAG, NGAL were measured at 5 time points first 24 h after operation normalized to...
Neutrophil gelatinase-associated lipocalin (NGAL) is rapidly released by renal tubules after injury, potentially allowing early identification of acute kidney injury (AKI) cardiac surgery. However, the diagnostic performance NGAL has varied widely in clinical studies, and it remains unknown what factors modify relationship between AKI. We hypothesized urinary AKI would vary with baseline function, a stratified analysis to improve this novel biomarker.We performed prospective observational...
Abstract Introduction Thromboembolic complications contribute substantially to perioperative morbidity and mortality. Routine laboratory tests do not detect patients with acquired or congenital hypercoagulability who may be at increased risk of thromboembolism. Rotational thromboelastometry (ROTEM) is a digitized modification conventional thromboelastography that stable technically easy use. We designed prospective observational study evaluate whether preoperative ROTEM can identify for...
Two metrics, a rise in serum creatinine concentration and decrease urine output, are considered tantamount to the injury of kidney tubule epithelial cells thereof (AKI). Yet neither criterion emphasizes etiology or pathogenetic heterogeneity acute decreases excretory function. In fact, whether decreased function due contraction extracellular fluid volume (vAKI) intrinsic (iAKI) actually share pathogenesis should be aggregated same diagnostic group remains an open question. To examine this...
Background. Urinary neutrophil gelatinase-associated lipocalin (NGAL) is a novel, sensitive and specific biomarker that rapidly released after kidney injury. It predicts acute injury (AKI) in multiple clinical scenarios. We hypothesized urinary NGAL can predict AKI liver transplantation.
DESPITE more than half a century of investigation, acute kidney injury (AKI) remains major healthcare issue in medicine today. Reported to occur 1–32% all hospital admissions and 10–90% intensive care unit admissions, the wide variation reflects different criteria used define AKI. However, independent definition, diagnosis AKI is consistently associated with an increase both short- long-term morbidity mortality. Even mildest forms are independently increased early as well mortality, risk...
Over the last decade age of liver transplant (LT) recipients and likelihood coronary artery disease (CAD) in this population have increased. There are no multicenter studies that examined impact CAD on LT outcomes. In historical cohort study, we identified adult who underwent angiography prior to transplantation at seven institutions over a 12-year period. For each patient recorded demographic data, recipient donor risk factors, duration follow-up, presence angiographically proven...
Background. Critically ill cirrhotic patients are increasingly transplanted, but there is no consensus about futile liver transplantation (LT). Therefore, the decision to delay or deny LT often extensively debated. These debates arise from different opinions of futility among transplant team members. This study aims achieve a multinational and multidisciplinary on definition in develop well-articulated criteria for not proceeding with due futility. Methods. Thirty-five international experts...
Early allograft dysfunction (EAD) is a serious complication after liver transplantation (LT). There no uniform definition of EAD, and most definitions are based on arbitrary laboratory values. The aim this study was to devise EAD that maximizes the predictive power for early death graft failure. In single-center, retrospective study, ability international normalized ratio (INR), total bilirubin, aspartate aminotransferase (AST), physiological Model End-Stage Liver Disease (MELD) score, serum...
<i>Background:</i> Use of aprotinin has been associated with acute kidney injury after cardiac surgery. Neutrophil gelatinase-associated lipocalin (NGAL) is a novel, very sensitive marker for renal injury. Urinary NGAL may be able to detect caused by aprotinin. This study determined if the use an increased incidence and levels urinary NGAL. <i>Methods:</i> In this prospective, observational 369 patients undergoing surgery were enrolled. 205 received 164 epsilon...
IntroductionThis prospective study tests the hypothesis that after general surgery urinary neutrophil gelatinase–associated lipocalin (NGAL) can distinguish between sustained acute kidney injury (AKI), typical of nephron damage, and transient AKI, commonly seen with hemodynamic variation prerenal azotemia.MethodsUrine was collected in 510 patients within 2 to 3 hours surgery, NGAL determined using enzyme-linked immunosorbent assay. Patients who met AKIN stage 1 criteria AKI were...