A5025856213- COVID-19 Clinical Research Studies
- Dermatological and COVID-19 studies
- COVID-19 and healthcare impacts
- S100 Proteins and Annexins
- Blood properties and coagulation
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
Columbia University
2021-2024
Columbia University Irving Medical Center
2021-2022
Emory University Hospital
2021
Mechanistically driven therapies for atrial fibrillation (AF), the most common cardiac arrhythmia, are urgently needed, development of which requires improved understanding cellular signaling pathways that facilitate structural and electrophysiological remodeling occurs in atria. Similar to humans, increased persistent Na+ current leads an myopathy spontaneous long-lasting episodes AF mice. How causes both atria is unknown. We crossbred mice expressing human F1759A-NaV1.5 channels with...
Abstract We measured plasma levels of fibrinogen, plasminogen, tissue plasminogen activator (t-PA) and activation inhibitor 1 (PAI-1) in blood from 37 patients with severe coronavirus disease-19 (COVID-19) 23 controls. PAI-1, t-PA fibrinogen were significantly higher the COVID-19 group. Increased PAI-1 likely result lower plasmin activity hence decreased fibrinolysis. These observations provide a partial explanation for fibrin- mediated increase viscosity hypercoagulability that has...
Severe coronavirus disease-19 (COVID-19) has been associated with fibrin-mediated hypercoagulability and thromboembolic complications. To evaluate potential biomarkers of coagulopathy disease severity in COVID-19, we measured plasma levels eight potentially coagulation, fibrinolysis, platelet function 43 controls 63 COVID-19 patients, including 47 patients admitted to the intensive care unit (ICU) 16 non-ICU patients. showed significantly elevated fibrinogen, tissue plasminogen activator...
Background: Atrial fibrillation (AF) increases the risk of cognitive decline and dementia independent stroke or comorbidities. However, mechanism is poorly understood there no animal model studying effects persistent AF on brain. Objectives: We studied a genetic mouse with spontaneous to assess performance, brain structure, vascular function investigate if expression mitochondrial catalase can improve these deficits in mice. Methods: have previously established double transgenic expressing...