A5063224703- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Ion channel regulation and function
- Cardiac Arrhythmias and Treatments
- Neuroscience and Neural Engineering
- Cardiovascular Function and Risk Factors
- Mitochondrial Function and Pathology
- Cardiomyopathy and Myosin Studies
- Receptor Mechanisms and Signaling
- Electrochemical Analysis and Applications
- Phosphodiesterase function and regulation
- Integrated Circuits and Semiconductor Failure Analysis
- Analytical Chemistry and Sensors
- ATP Synthase and ATPases Research
- Semiconductor materials and devices
- Calcium signaling and nucleotide metabolism
- Parkinson's Disease Mechanisms and Treatments
- Caveolin-1 and cellular processes
- Mechanical Circulatory Support Devices
- Electron Spin Resonance Studies
- Advanced MRI Techniques and Applications
- Force Microscopy Techniques and Applications
- Cellular transport and secretion
- Electrostatic Discharge in Electronics
- Fuel Cells and Related Materials
University of Maryland, Baltimore
2015-2025
University of Baltimore
2024
University of Mary
2023
Maastricht University
2005-2013
McGill University
2010
Université de Montréal
2010
Ludwig-Maximilians-Universität München
2010
Chang Gung University
2010
Chang Gung Memorial Hospital
2010
Amsterdam UMC Location Vrije Universiteit Amsterdam
2010
Atrial fibrillation (AF) is characterized by sustained high atrial activation rates and arrhythmogenic cellular Ca2+ signaling instability; however, it not clear how a rate instability may be related. Here, we subcellular after 5 days of in rabbit model. While some changes were similar to those persistent AF, identified distinct pattern stabilized signaling. sparks, waves, sarcoplasmic reticulum (SR) leak, SR content largely unaltered. Based on computational analysis, these findings...
Background— Atrial fibrillation impairs atrial contractility, inducing stunning that promotes thromboembolic stroke. Action potential (AP)-prolonging drugs are reported to normalize hypocontractility caused by tachycardia remodeling (ATR). Here, we addressed the role of AP duration (APD) changes in ATR-induced hypocontractility. Methods and Results— ATR (7-day tachypacing) decreased APD (perforated patch recording) ≈50%, contractility (echocardiography, cardiomyocyte video edge detection),...
The loss of atrial contractile function after cardioversion fibrillation (AF) contributes to the thromboembolic risk associated with AF. newly developed blocker transient outward current (I(to)) and ultrarapid delayed rectifier (I(Kur)) AVE0118 prolongs action potential duration might therefore enhance contractility. We compared ability restore contraction AF efficacy conventional positive inotropic compounds in goat model AF.Eighteen goats were chronically instrumented epicardial...
AVE0118 (2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)-amide) blocks atrial ultrarapid delayed rectifier currents (I(Kur)) and prolongs the action potential (AP) plateau without affecting ventricular repolarisation. In patients with contractile dysfunction due to tachyarrhythmias, this response might increase contractility risk of proarrhythmia. This study was designed evaluate inotropic mechanisms AVE0118.In isometrically contracting...
Mechanistically driven therapies for atrial fibrillation (AF), the most common cardiac arrhythmia, are urgently needed, development of which requires improved understanding cellular signaling pathways that facilitate structural and electrophysiological remodeling occurs in atria. Similar to humans, increased persistent Na+ current leads an myopathy spontaneous long-lasting episodes AF mice. How causes both atria is unknown. We crossbred mice expressing human F1759A-NaV1.5 channels with...
Obscurin is a giant protein that coordinates diverse aspects of striated muscle physiology. immunoglobulin domains 58/59 (Ig58/59) associate with essential sarcomeric and Ca2+ cycling proteins. To explore the pathophysiological significance Ig58/59, we generated Obscn-ΔIg58/59 mouse model, expressing obscurin constitutively lacking Ig58/59. Males in this line develop atrial fibrillation by 6-months, ventricular dilation 12-months. As left ventricles at 6-months exhibit no deficits...
Mitochondrial ATP production in ventricular cardiomyocytes must be continually adjusted to rapidly replenish the consumed by working heart. Two systems are known critical this regulation: mitochondrial matrix Ca 2+ ([Ca ] m ) and blood flow that is tuned local cardiomyocyte metabolic signaling. However, these two regulatory do not fully account for physiological range of consumption observed. We report here on identity, location, signaling cascade a third system -- CO 2 /bicarbonate....
Abstract Heart Failure with preserved ejection fraction (HFpEF) is the most prevalent form of heart failure worldwide and its significant mortality associated a high rate sudden cardiac death (SCD; 30% - 40%). Chronic metabolic stress an important driver HFpEF, clinical data show as risk factor for ventricular arrhythmias in HFpEF patients. The mechanisms SCD arrhythmia remain critically understudied empirical treatment ineffective. To address this knowledge gap, we developed novel...
Background In human ventricular myocardium, contractile force increases at higher stimulation frequencies (positive force-frequency relation). failing hearts, the relation (FFR) is negative. Data on effect of volatile anesthetics FFR are very limited. Methods The authors obtained left tissue from 18 explanted hearts patients undergoing cardiac transplantation and 8 organ donors. negative inotropic halothane, isoflurane, sevoflurane isometric contraction isolated muscle preparations a...
Intracellular sodium concentration ([Na+]i) is an important regulator of intracellular Ca2+. Its study provides insight into the activation sarcolemmal Na+/Ca2+ exchanger, behavior voltage-gated Na+ channels and Na+,K+-ATPase. Ca2+ signaling altered in atrial diseases such as fibrillation. While many mechanisms underlying homeostasis are characterized, role [Na+]i its dysregulation pathologies poorly understood. myocytes increases response to increasing stimulation rates. Responsiveness...