A5077495277- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Molecular Biology Techniques and Applications
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Chronic Lymphocytic Leukemia Research
- Helicobacter pylori-related gastroenterology studies
- Cell death mechanisms and regulation
- Natural Compounds in Disease Treatment
- Occupational and environmental lung diseases
- Photodynamic Therapy Research Studies
- interferon and immune responses
- Coenzyme Q10 studies and effects
- Glutathione Transferases and Polymorphisms
- Lung Cancer Treatments and Mutations
- Cytokine Signaling Pathways and Interactions
- Gastric Cancer Management and Outcomes
- Genomics, phytochemicals, and oxidative stress
- RNA regulation and disease
- Autophagy in Disease and Therapy
Second Hospital of Shandong University
2018-2024
Shandong University
2020-2023
Shandong Maternal and Child Health Hospital
2020
Shandong Provincial Hospital
2019
SignalRx Pharmaceuticals (United States)
2018
State Council of the People's Republic of China
2018
Third Xiangya Hospital
2016
Central South University
2016
Emory University
2013-2016
Winship Cancer Institute
2014
Malignant pleural mesothelioma (MPM) is a rare form of cancer that associated with asbestos exposure. Unfortunately, current therapies have limited efficacy. Previous studies indicated curcumin exerts antiproliferative and antitumor effects, has low toxicity. The present study aimed to evaluate the anticancer effects on RN5 MPM cell line. inhibitory viability were determined using sulforhodamine B assay. In addition, cycle progression was analyzed by propidium iodide (PI) staining flow...
Several parameters may predict disease severity and overall survival in chronic lymphocytic leukemia (CLL). The purpose of our study 190 CLL patients was to compare immunoglobulin heavy chain variable region (IgV(H)) mutation status, cytogenetic abnormalities, cell CD38 Zap-70 older, traditional parameters. We also wanted construct a simple, inexpensive prognosis score that would significantly TTT at the time diagnosis help practicing clinicians. In univariate analyses, with higher clinical...
BACKGROUND To understand the mechanism of frequent and early lymph node metastasis in high‐risk human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma (OPSCC), this study investigated whether β‐catenin is regulated by HPV oncoprotein contributes to OPSCC metastasis. METHODS Expression levels p16, β‐catenin, epidermal growth factor receptor (EGFR) were examined samples (n = 208) immunohistochemistry. The expression subcellular localization EGFR activation also studied...
Researches have indicated that microRNA-506-3p (miR-506-3p) was downregulated and functioned as tumor suppressor in cancers. However, the biological role of miR-506-3p prostate cancer (PCa) remains to be elucidated.Expression PCa cell lines measured by qRT-PCR. Effects expression on behaviors were investigated with MTT assay, colony formation transwell invasion assay. Connection N-Acetylgalactosaminyltransferase-4 (GALNT4) analyzed luciferase activity reporter assay Western blot...
Abstract Historically, phenotypic-based drug discovery has yielded a high percentage of novel drugs while uncovering new tumor biology. CC-671 was discovered using phenotypic screen for compounds that preferentially induced apoptosis in triple-negative breast cancer cell lines sparing luminal lines. Detailed vitro kinase profiling shows potently and selectively inhibits two kinases—TTK CLK2. Cellular mechanism action studies demonstrate the phosphorylation KNL1 SRp75, direct TTK CLK2...
Chemotherapy is one of the primary treatments for both small cell lung cancer (SCLC) and non-small (NSCLC), however, chemoresistance develops over time a bottleneck to effective chemotherapy worldwide. Therefore, development new potent therapeutic agents overcome utmost importance. Triptolide natural component extracted from Tripterygium Wilfordii, Chinese plant; our study aimed evaluate its anti-tumor effects in taxol-resistant human adenocarcinoma investigate molecular mechanisms...
Background and Objectives Our group recently synthesized a new, low‐cost photosensitizer, chlorophyllin f. In this study, the effects of f‐mediated photodynamic therapy (PDT) its potential mechanisms were examined in human bladder cancer cells. Materials Methods MitoTracker® Green probe LysoTracker® used to label mitochondria lysosomes, revealing intracellular localization f 5637 T24 cells by confocal laser scanning microscopy (CLSM). The treated with PDT; photo‐cytotoxicity was monitored...
Background and aim: Long non-coding RNA nuclear-enriched abundant transcript 1 (NEAT1) is abnormally expressed in various human malignancies, including hepatocellular carcinoma (HCC). Let-7b a miRNA with the effect of tumor suppressor gene, its expression level tissues lower than that normal tissues. Studies have found IGF-1R can be activated process hepatocyte deterioration, HCC significantly up-regulated. The aim this study was to investigate functional mechanism NEAT1/let-7b-IGF-1R axis...
The aim of this study was to clarify whether long non-coding RNA (lncRNA) human ovarian cancer-specific transcript 2 (HOST2) could enhance gefitinib-resistance in non-small cell lung cancer (NSCLC) by down-regulating microRNA-621 (miRNA-621).The relative expression levels HOST2, miRNA-621 and SYF2 NSCLC lines were determined quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). regulatory effects HOST2 on the proliferative ability cycle cells evaluated Cell Counting Kit-8 (CCK-8) assay...
<i>clk-1</i> has been identified and characterized in the nematode <i>Caenorhabditis elegans</i> as a gene that affects rates, regularity, synchrony of physiological processes. The CLK-1 protein is mitochondrial required for ubiquinone biosynthesis yeast worms, but its biochemical function remains unclear. We have studied expression murine<i>mclk1</i> variety tissues, we find pattern <i>mclk1</i> mRNA accumulation closely resembles genes involved oxidative phosphorylation. accumulation,...
To predict lymph node metastasis and prognosis in head neck squamous cell carcinoma (HNSCC).The combination of membranous E-cadherin epidermal growth factor receptor (EGFR) quantified by QD technology with age, gender, grade had greater predictive power than any the single biomarkers or two combined conventional immunohistochemistry (IHC). The this model was validated another independent sample set; sensitivity for LNM 87.5%, specificity up to 97.4%, accuracy 92.9%. Furthermore, a higher...
Here, we describe a novel method using microwave ablation (MWA) guided by electromagnetic navigation bronchoscopy (ENB) and video‐assisted thoracoscopic surgery (VATS) for simultaneous treatment of multiple high‐risk pulmonary nodules in 47‐year‐old woman. After the ENB registration process, operator delivered locatable probe to target right upper lobe following navigational route. MWA was performed after an antenna passed into lesion through working channel. The wedge resection left lower...
Abstract Background To distinguish early‐stage lung cancer from benign disease in pulmonary nodules, especially lesions with ground‐glass opacity (GGO), we assessed gene mutations of ctDNA peripheral blood using targeted next‐generation sequencing (NGS). Methods Single nodule patients without mediastinal lymph nodes and symptoms that were hard to diagnose by chest CT biomarker measurement multiple medical centers enrolled into the study. All accepted minimally invasive surgery but refused...
Exosomal microRNAs (miRNAs) in the tumor microenvironment play crucial roles tumorigenesis and progression by participating intercellular cross-talk. However, functions of exosomal miRNAs mechanisms which they regulate esophageal squamous cell carcinoma (ESCC) are unclear.
To evaluate the effect of muscovite in preventing small bowel injury induced by nonsteroidal anti-inflammatory drugs (NSAIDs).We recruited and screened thirty-two healthy volunteers who were randomly allocated equally into two groups: an NSAID control group, received 75 mg slow-release diclofenac, twice daily for 14 d; NSAID-muscovite 3 g addition to d. For gastroprotection, both groups administered 20 mg/d proton pump inhibitor omeprazole. All eligible subjects underwent video capsule...
Abstract Background Lung cancer represents a significant public health issue in China, given its high incidence and mortality rates. Circular RNAs (circRNAs) have been recently proposed to participate the development progression of tumors. Nevertheless, their particular roles pathogenesis lung adenocarcinoma (LUAD), tumor microenvironment (TME), underlying molecular mechanisms are still not well understood. Methods High-throughput sequencing was used analyze circRNAs expression profiles 7...
The goal is to synthesize an FSM with the objective minimize number of scanned flip-flops while requiring a minimum system clocks reach synchronizable state. An algorithm for selecting state variables scanning minimizing length synchronizing sequence based on reverse-order-search technique presented. Extra transitions may be required avoid possible lock-in conditions if initial invalid machines where states not power 2. Experimental results show that proposed method guarantees...
To investigate the reversal effect of methylseleninic acid on cisplatin (DDP)-resistant ovarian cancer cells and underlying mechanisms. Methods: SKOV3/DDP were incubated with at different concentrations for 48 h, then proliferation rate was detected by MTT assays, expression β-catenin in examined Western blot. The inhibitory methyl-seleninic (MSA) combined DDP assayed method. blot used to detect protein cells. Results: DDP-treated is lower than that SKOV3 (P<0.05); significantly higher...
SMAC exhibits anti-tumor effects in ECA109 cells by regulating expression of inhibitor apoptosis protein family
Objective To investigate the injury of nonsteroidal anti-inflammatory drug (NSAID) in small intestinal mucosa and protective role muscovite.Methods From December 2012 to June 2013,28 healthy volunteers without mucosal showed by capsule endoscopy were selected as objects this study.Based on computer-generated random number table,the subjects divided into muscovite group control group.Subjects orally took 3 g twice daily,diclofenac 75 mg daily omeprazole 20 once a day.The medicine for same but...