A5084033276- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Organ Transplantation Techniques and Outcomes
- Protein Degradation and Inhibitors
- Chronic Myeloid Leukemia Treatments
- Advancements in Semiconductor Devices and Circuit Design
- Sepsis Diagnosis and Treatment
- Electrolyte and hormonal disorders
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune Cell Function and Interaction
- Mitochondrial Function and Pathology
- Underwater Vehicles and Communication Systems
- Biosimilars and Bioanalytical Methods
- Neuroscience and Neural Engineering
- Hematopoietic Stem Cell Transplantation
- Renal function and acid-base balance
- Sirtuins and Resveratrol in Medicine
- Adrenal Hormones and Disorders
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Pediatric Hepatobiliary Diseases and Treatments
- Gastric Cancer Management and Outcomes
- Indoor and Outdoor Localization Technologies
Wuhan General Hospital of Guangzhou
2022-2024
Southwest Hospital
2019-2023
Army Medical University
2019-2023
General Hospital of Central Theater Command
2023
Chongqing Cancer Hospital
2021
Chongqing University
2021
State Council of the People's Republic of China
2018
Air Force Medical University
2012
Metabolic reprogramming endows cancer cells with the ability to adjust metabolic pathways support heterogeneously biological processes. However, it is not known how reprogrammed activities are implemented during differentiation of stem (CSCs). In this study, we demonstrated that liver CSCs relied on enhanced mitochondrial function maintain stemness properties, which different from aerobic glycolysis playing main roles in differentiated non‐CSCs. We found exhibit increased respiratory...
Abstract Purpose: Immunogenicity derived from the murine scFv, a major molecular compomemt of chimeric antigen receptors (CARs), may limit persistence CAR T cells, resulting in tumor relapse patients complete remission (CR). In this study, we developed humanized anti-CD19 scFv CAR-T (hCAR-T) to treat with relapsed/refractory acute lymphoblastic leukemia (r/r ALL). Patients and Methods: one-arm, open-labeled infused cells modified hCAR r/r ALL. were evaluated long-term follow-up for response...
Abstract Background Leukemia stem cells (LSCs) are responsible for the initiation, progression, and relapse of acute myeloid leukemia (AML). Therefore, a therapeutic strategy targeting LSCs is potential approach to eradicate AML. In this study, we aimed identify LSC-specific surface markers uncover underlying mechanism AML LSCs. Methods Microarray gene expression data were used investigate candidate AML-LSC-specific markers. CD9 in cell lines, patients with AML, normal donors was evaluated...
Abstract Background Biliary complications, especially non‐anastomotic stricture (NAS), are the main complications after liver transplantation. Insufficient sampling and no recognized animal models obstruct investigation. Thus, mechanisms alterations that occur during endoscopic treatment (ET) of NAS remain unclear. Methods Samples were obtained with forceps from hilar bile ducts patients receiving continuous biliary stent implantation diagnosis. Retrospective analysis multiple studies...
In recent years, the research of high-precision positioning with wireless sensor networks has attracted a lot attention, especially in scenarios UAV (unmanned aerial vehicles) assisted positioning. This paper proposes new method getting more accurate range information. contrast to existing traditional works, we use multiple information instead single distance First, transmits beacon packets each node at random positions and all nodes record RSSI (Received Signal Strength Indicator) vectors....
While many factors that are associated with increased mortality in septic shock patients have been identified, the effects of serum osmolarity on outcomes ICU not yet studied. The present study was designed to examine association 28-day shock. Adult diagnosed from MIMIC-IV database were selected this study. calculated synchronously according concentrations Na+, K+, glucose, and urea nitrogen. In study, a significant difference observed between hypo-osmolarity, hyper-osmolarity, normal...
Although corticosteroids are recommended in the 2021 Surviving Sepsis Campaign (SSC) guidelines, evidence with respect to their effects on short-term mortality remains conflicting. We conducted this study identify whether alter 28-day septic shock patients gram-negative bacterial infection.A total of 621 and culture results were identified from Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Propensity score matching (PSM) was performed, Kaplan-Meier survival curve...
To study the effects of low-frequency cortical electrical stimulation (CES) on seizures and behaviour in a rat model epilepsy induced by ferric chloride (FeCl3).Rats were randomly assigned into four groups (n=8 per group): normal healthy rats; saline-treated control FeCl3-induced epileptic CES-treated rats. Behavioural tests, analysis levels brain-derived neurotrophic factor (BDNF) protein brain tissue, ultrastructural studies using transmission electron microscopy (TEM) undertaken.CES...
Background Carbohydrate antigen 242 has been clinically used as a diagnostic biomarker for pancreatic cancer. However, the prognostic role of CA242 in hilar cholangiocarcinoma (HCCA) not identified. Also, it remains unclear to what extents vascular invasion and lymph node metastasis mediate effect serum on prognosis. Objective This study aimed investigate whether relationship between levels clinical prognosis HCCA patients after radical resection. Methods Data 234 who accepted resection from...
Abstract Background: Leukemia stem cells (LSCs) are responsible for the initiation, progression and relapse of acute myeloid leukemia (AML). Therefore, a therapeutic strategy targeting LSCs is potential approach to eradicate AML. In this study, we aimed identify LSC-specific surface markers uncover underlying mechanism AML LSCs. Methods: Microarray gene expression data were used investigate candidate AML-LSC-specific markers. CD9 in cell lines, patients with normal donors was evaluated by...
Background: Immunogenicity derived from the murine scFv, a major molecular design of CAR, may limit persistence CAR-T cells, resulting in high relapase rate cured relapsed/refractory acute lymphoblastic leukemia (r/r ALL) patients after successful treatment. In this study, we aimed to develop humanized anti-CD19 scFv (hCAR-T) and treated with r/r ALL. Methods: one-arm, open-labelled phaseⅠ/Ⅱ infused T cells modified hCAR-T Long term followup for response safety treatment were evaluated....
Abstract Background: Leukemia stem cells (LSCs) are responsible for the initiation, progressing and relapse of acute myeloid leukemia (AML). Therefore, therapy strategy targeting LSCs is hopeful to eradicate AML. In this study, we aimed identify LSCs-specific surface markers uncover underlying mechanism AML LSCs. Methods: Microarray gene expression data were used investigate candidate AML-LSCs specific markers. CD9 was evaluated by flow cytometry (FC) in cell lines, patients with normal...
<p>This Supplementary information consists of (1) materials and methods FCM; (2) 1 table 8 supplementary figures.</p>
<div>AbstractPurpose:<p>Immunogenicity derived from the murine scFv, a major molecular compomemt of chimeric antigen receptors (CARs), may limit persistence CAR T cells, resulting in tumor relapse patients complete remission (CR). In this study, we developed humanized anti-CD19 scFv CAR-T (hCAR-T) to treat with relapsed/refractory acute lymphoblastic leukemia (r/r ALL).</p>Patients and Methods:<p>In one-arm, open-labeled infused cells modified hCAR r/r ALL. Patients...
<div>AbstractPurpose:<p>Immunogenicity derived from the murine scFv, a major molecular compomemt of chimeric antigen receptors (CARs), may limit persistence CAR T cells, resulting in tumor relapse patients complete remission (CR). In this study, we developed humanized anti-CD19 scFv CAR-T (hCAR-T) to treat with relapsed/refractory acute lymphoblastic leukemia (r/r ALL).</p>Patients and Methods:<p>In one-arm, open-labeled infused cells modified hCAR r/r ALL. Patients...
<p>This Supplementary information consists of (1) materials and methods FCM; (2) 1 table 8 supplementary figures.</p>
Abstract Background: Leukemia stem cells (LSCs) are responsible for the initiation, progress and relapse of acute myeloid leukemia (AML). Therefore, therapy strategy targeting LSCs is hopeful to eradicate AML. In this study, we aim identify LSC-specific surface markers uncover underlying mechanism AML LSCs. Methods: Microarray gene expression data were used investigate candidate AML-LSC specific markers. CD9 was evaluated by flow cytometry in cell lines, patients with normal donors. The...
Abstract Purpose: While many factors that are associated with increased mortality in septic shock patients have been identified, the effect of serum osmolarity to altering patient outcomes among ICU has not studied. This study was designed examine association 28-day population. Methods: The MIMIC-IV database employed identify diagnosed shock. calculated according concentration Na + , K glucose and urea nitrogen synchronously. statistical approaches used included multivariate logistic...
Abstract Background： Natural killer cells are innate cytotoxic lymphocytes that play an important role in the anti-tumor immune response. However, microenvironment of solid tumors, effector functions NK often impaired by induction checkpoint inhibitors, including PD-1. Methods: In this study, we conducted a two-phase study treating advanced patients with cell therapy (phase 1) or and anti-PD-1 inhibitor, pembrolizumab 2). Results: After treatment, only 3 9 achieved stable disease after...