A5101512596- Histone Deacetylase Inhibitors Research
- Proteins in Food Systems
- Protein Hydrolysis and Bioactive Peptides
- Gut microbiota and health
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Nanoparticle-Based Drug Delivery
- Inflammatory Biomarkers in Disease Prognosis
- Insect Utilization and Effects
- Biochemical effects in animals
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Bacterial Infections and Vaccines
- Time Series Analysis and Forecasting
- Chronic Kidney Disease and Diabetes
- Dendrimers and Hyperbranched Polymers
- Tuberous Sclerosis Complex Research
- Microbial Inactivation Methods
- Adrenal and Paraganglionic Tumors
- Ginseng Biological Effects and Applications
- Surgical Simulation and Training
- Alcohol Consumption and Health Effects
- Hepatocellular Carcinoma Treatment and Prognosis
- Protist diversity and phylogeny
Xinjiang Institute of Ecology and Geography
2024-2025
Chinese Academy of Sciences
2024-2025
State Key Laboratory of Food Science and Technology
2024
Nanchang University
2024
Henan University of Technology
2024
University of Chinese Academy of Sciences
2024
Qinghai University
2024
Soochow University
2024
First Hospital of China Medical University
2024
Xuchang University
2024
We aimed to investigate the association of visceral adiposity index (VAI) with decreased renal function in US adults.Cross-sectional data were analyzed for 35,018 adults National Health and Nutrition Examination Survey (NHANES) 2005-2018. VAI was determined using waist circumference, body mass (BMI), triglycerides (TGs) high-density lipoprotein-cholesterol. Albuminuria defined as urinary albumin-to-creatinine ratio (ACR) >30 mg/g. A low estimated-glomerular filtration rate (eGFR) an eGFR...
High Fischer ratio oligopeptides (HFOs) exhibit diverse biological activities, including anti-inflammatory and antioxidant properties. HFOs from gluten origin were prepared through fermentation enzymatic hydrolysis then characterized using free amino acid analysis scanning electron microscopy (SEM). Following intervention, the levels of serum total cholesterol (TC), triglyceride (TG), alanine aminotransferase (ALT), aspartate (AST), hepatic malondialdehyde (MDA) in rats significantly...
Systemic chronic inflammation is recognized as a significant contributor to the development of obesity-related insulin resistance. Previous studies have revealed physiological benefits resistant dextrin (RD), including obesity reduction, lower fasting glucose levels, and anti-inflammation. The present study investigated effects RD intervention on resistance (IR) in Kunming mice, expounding mechanisms through gut microbiome transcriptome white adipose. In this eight-week study, we changes...
Objective The purpose of this study was to investigate the clinical significance serum high sensitive C-reactive protein/albumin ratio in primary prostate biopsy. Methods Retrospective analysis done on data 1679 patients who had their first transrectal or perineal biopsy at our situation from 2010 2018. Prostate cancer (PCa) and benign prostatic hyperplasia (BPH) were pathologic diagnoses 819 860 cases, respectively. A comparison made between HAR differences PCa BPH as well positive rate...
Utilizing wheat embryos as the raw material and employing Aspergillus niger fermentation strain, embryo polypeptides were produced through microbial liquid fermentation. The protein concentration post-fermentation served response variable, preparation process underwent optimization single-factor testing a surface methodology, followed by assessment of antioxidant activity. findings revealed that optimal conditions for peptide via included duration 24 h, an inoculum volume 4%, initial pH 7,...
In recent studies, combinations of histone deacetylases (HDACs) inhibitor with kinase showed additive and synergistic effects. BRafV600E as an attractive target in many diseases treatments has been studied extensively. Herein, we present a novel design approach though incorporating the pharmacophores HDACs one molecule. Several synthesized compounds exhibited distinct HDAC1 inhibitory activities. The representative dual Raf/HDAC inhibitor, 7a, better antiproliferative activities against A549...
The efficacy of selenium-chelating polypeptides derived from wheat protein hydrolysate (WPH-Se) includes enhancing antioxidant capacity, increasing bioavailability, promoting nutrient absorption, and improving overall health. This study aimed to enhance the bioavailability functional benefits exogenous selenium by chelating with gluten peptides, thereby creating bioactive peptides potentially higher capabilities. In this study, WPH-Se was prepared peptide at a mass ratio 2:1, under reaction...
Histone deacetylases (HDACs) are important targets in cancer treatment, and the development of selective broad-spectrum HDACs inhibitors (HDACis) is urgent. In this research, a series aroylpiperazine hybrid derivatives were designed synthesized. Among these, indole-piperazine hybrids 6a (IC50 = 205 nM) 6b 280 showed submicromolar activity against HDAC1. Moreover, preferable affinity toward class I HDACs, especially for HDAC1-3. vitro, exhibited better antiproliferative activities K562 HCT116...
Currently, the dynamic erosive small molecule nano-prodrug is of great demand for oral chemotherapy, owing to its precise structure, high drug loading and improved bioavailability via overcoming various physiologic barriers in gastrointestinal tract, blood circulation tumor tissues compared other nanomedicines. Herein, this work highlights successful development pH-triggered nano-prodrugs based on vivo significant pH changes, which are synthesized amide reaction between chlorambucil...
To achieve highly selective synergistic chemotherapy attractive for clinical translation, the precise polymeric nano-prodrugs (PPD-NPs) were successfully constructed via facile crosslinking reaction between pH-sensitive poly(ortho ester)s and reduction-sensitive small molecule prodrug (Pt(IV)-1). PPD-NPs endowed defined structure high drug loading of cisplatin demethylcantharidin (DMC). Moreover, exhibited steady long-term storage circulation crosslinked structure, suitable negative...
Adrenal myelolipomas are benign tumors composed mainly of lipomatous elements with myeloid cells. With the development medical imaging technology, detection rate has gradually increased. We report a case adrenal myelolipoma successfully excised through laparoscope and reviewed existing literature in recent ten years to summarize feasibility laparoscopic approach for this tumor. Herein, we described resected by 63-year-old male patient. He did not have any other symptoms except incidental...
Intestinal parasites, such as
<title>Abstract</title> <bold>Objective</bold> Ovarian cancer is a common gynecological malignant tumor, and its incidence ranks high among female tumors. Based on network pharmacology bioinformatics analysis, the mechanism of GFC in treatment ovarian was explored by vitro vivo experiments. Methods: Firstly, target genes effective chemical components were screened, used to identify potential targets cancer. Then, prediction results verified cell animal Finally, use LC-MS/MS representative...
Protein hydrolysates from the goat placenta provide multiple benefits, such as immune system enhancement, antioxidant activities, and reductions in uric acid levels. Despite these their industrial applications have been underexplored. This study aimed to prepare extract protein (GPERPs) residual (GPER) assess functional properties, focusing on how different drying methods influence properties. The essential amino contents were 30.94% for GPER 34.11% GPERPs. Moreover, all acids present, score...
ABSTRACT Plant community construction is influenced by bottom‐up processes, such as environmental factors, and top‐down herbivore disturbances. With climate change overgrazing, the stability of plant structure function decreases, more land at risk degradation. However, response to interference from native herbivores under similar conditions remains unclear. Plateau pika ( Ochotona curzoniae ) an important small rodent inhabiting alpine meadow Qinghai‐Tibetan Plateau, its disturbance may...
Spatial-temporal data collected across different geographic locations often suffer from missing values, posing challenges to analysis. Existing methods primarily leverage fixed spatial graphs impute which implicitly assume that the relationship is roughly same for all features locations. However, they may overlook relationships of diverse recorded by sensors in To address this, we introduce multi-scale Graph Structure Learning framework spatial-temporal Imputation (GSLI) dynamically adapts...