A5061072826- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
Anhui University
2022-2023
Currently, the dynamic erosive small molecule nano-prodrug is of great demand for oral chemotherapy, owing to its precise structure, high drug loading and improved bioavailability via overcoming various physiologic barriers in gastrointestinal tract, blood circulation tumor tissues compared other nanomedicines. Herein, this work highlights successful development pH-triggered nano-prodrugs based on vivo significant pH changes, which are synthesized amide reaction between chlorambucil...
To achieve highly selective synergistic chemotherapy attractive for clinical translation, the precise polymeric nano-prodrugs (PPD-NPs) were successfully constructed via facile crosslinking reaction between pH-sensitive poly(ortho ester)s and reduction-sensitive small molecule prodrug (Pt(IV)-1). PPD-NPs endowed defined structure high drug loading of cisplatin demethylcantharidin (DMC). Moreover, exhibited steady long-term storage circulation crosslinked structure, suitable negative...