A5031586464- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Bone fractures and treatments
- Titanium Alloys Microstructure and Properties
- Dental materials and restorations
- Dental Implant Techniques and Outcomes
- Nanoplatforms for cancer theranostics
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Polymer Surface Interaction Studies
- Infective Endocarditis Diagnosis and Management
- Graphene and Nanomaterials Applications
- Sarcoma Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
Peking University Third Hospital
2018-2023
Peking University
2018-2023
State Council of the People's Republic of China
2019-2020
Xinjiang Medical University
2017
First Affiliated Hospital of Xinjiang Medical University
2017
Bone defect repairs are based on bone graft fusion or replacement. Current large treatments inadequate and lack of reliable technology. Therefore, we aimed to investigate a simple technique using three-dimensional (3D)-printed individualized porous implants without any grafts, osteoinductive agents, surface biofunctionalization treat defects, systematically study its long-term therapeutic effects osseointegration characteristics. Twenty-six patients with defects caused by tumor, infection,...
Surgical resection and perioperative adjuvant chemotherapy-based therapies have improved the prognosis of patients with osteosarcoma; however, intraoperative bone defects, local tumour recurrence, chemotherapy-induced adverse effects still affect quality life patients. Emerging 3D-printed titanium alloy (Ti6Al4V) implants advantages over traditional in repair, including lower elastic modulus, stiffness, better conduction, more in-growth, stronger mechanical interlocking, lager drug-loading...
Three-dimensional (3D)-printed porous Ti6Al4V implants play an important role in the reconstruction of bone defects. However, its osseointegration capacity needs to be further improved, and related methods are inadequate, especially lacking customized surface treatment technology. Consequently, we aimed design omnidirectional radiator based on ultraviolet (UV) photofunctionalization for 3D-printed implants, studied promotion effects vitro vivo, while elucidating mechanisms. Following UV...
Sustainable release of vancomycin from micro-arc oxidised 3D-printed porous Ti6A14V for treating MRSA bone infection and enhancing osteogenesis.
Three-dimensional (3D)-printed porous Ti6Al4V implants are commonly used for reconstructing bone defects in the treatment of orthopaedic diseases owing to their excellent osteoconduction. However, achieve improved therapeutic outcomes, osteoinduction these requires further improvement. The aim this study was investigate combined use recombinant human BMP-2 (rhBMP-2) with a 3D-printed artificial vertebral implant (3D-AVI) improve osteoinduction. Eight male Small Tail Han sheep underwent...
Osteosarcoma is a malignant bone tumor occurring in adolescents. Surgery combined with adjuvant or neoadjuvant chemotherapy the standard treatment. However, systemic associated serious side effects and high risk of postoperative recurrence, leading to amputation rate mortality cancer patients. Implant materials that can simultaneously repair large defects prevent osteosarcoma recurrence are urgent need. Herein, an intelligent system comprising 3D-printed titanium scaffold (TS) pH-responsive...
Objective To evaluate the safety, feasibility and clinical efficacy of one-stage anterior transplantation with iliac crest allograft or autologous in treatment thoracolumbar tuberculosis. Methods From January 2012 to June 2015, 235 cases tuberculosis were treated allogeneic graft combined internal fixation during after radical debridement, which reviewed retrospectively. These divided into two groups: group (162 cases) autograft (73 cases). In group, there 87 males 75 females, a mean...
Background: Bone defect repairs are based on bone graft fusion or replacement. However, current large treatments inadequate and lack reliable technology. Therefore, we aimed to investigate a simple technique that uses three-dimensional (3D)-printed individualized porous implants without any grafts, osteoinductive agents, surface biofunctionalization treat defects systematically study its long-term therapeutic effects osseointegration characteristics.Methods: Twenty-six patients with caused...