A5102866611- Cancer-related gene regulation
- RNA modifications and cancer
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- dental development and anomalies
- Mitochondrial Function and Pathology
- Periodontal Regeneration and Treatments
- Chromatin Remodeling and Cancer
- Biochemical Acid Research Studies
- Oral and Maxillofacial Pathology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Endodontics and Root Canal Treatments
- Bone and Dental Protein Studies
- Cancer Cells and Metastasis
- Biochemical and Molecular Research
- Lipoproteins and Cardiovascular Health
- Genetic factors in colorectal cancer
- Chemical Synthesis and Reactions
- Genetic Syndromes and Imprinting
- Dental Radiography and Imaging
- Transplantation: Methods and Outcomes
- Selenium in Biological Systems
- Dental Erosion and Treatment
- Lysosomal Storage Disorders Research
Wenzhou Medical University
2025
Sichuan University
2015-2024
State Key Laboratory of Oral Diseases
2021-2023
West China Hospital of Sichuan University
2022-2023
Dalian Medical University
2020
Affiliated Hospital of Zunyi Medical College
2017-2019
State Key Laboratory of Biotherapy
2017-2019
Jiangsu Cancer Hospital
2016
Nanchang University
2016
First Affiliated Hospital of Nanchang University
2016
Breast cancer anti-estrogen resistance 4 (BCAR4) is closely associated with colorectal (CRC) initiation and propagation. However, the mechanisms underlying BCAR4 function in colon remains largely unknown. In this study, we hypothesized that could regulate stem/initiating cells (CSC) further facilitates progression.qRT-PCR was used to examine expression of various CSC markers. FACS, acetaldehyde dehydrogenase (ALDH) activity western blot assays were applicable test CCK8, tumorsphere formation...
The pulpotomy with pulp capping is aimed at retaining vital reparative dentin formation. Vascular endothelial growth factor (VEGF) plays a crucial role in regeneration; however, its constant administrations the human body still problematic. Chitosan was widely studied as an effective carrier to deliver bioactive molecules regenerative medicine. In this study, we conducted chitosan/β-glycerophosphate (CS/β-GP) hydrogel VEGF-sustained release system and explored effects on dental stem cells...
Abstract Objectives The odontoblastic differentiation of dental pulp stem cells (DPSCs) contributes to tertiary dentin formation. Our previous study indicated that epiregulin (EREG) enhanced odontogenesis potential pulp. Here, we explored the effects EREG during DPSC differentiation. Methods changes in were detected DPSCs treated with recombinant human (rhEREG), receptor inhibitor gefitinib and short hairpin RNAs. was assessed ALP staining, activity assay, alizarin red S staining real‐time...
Abstract Background Epigenetic factors influence the odontogenic differentiation of dental pulp stem cells and play indispensable roles during tooth development. Some microRNAs can epigenetically regulate other epigenetic like DNA methyltransferases histone modification enzymes, functioning as epigenetic-microRNAs. In our previous study, microarray analysis suggested microRNA-93-5p (miR-93-5p) was differentially expressed bell stage in human germ. Prediction tools indicated that miR-93-5p...
// Shurui Ouyang 1 , Xinbin Zheng Xin Zhou Zhengquan Chen Xuefeng Yang and Ming Xie Gastrointestinal Department, Affiliated Hospital of Zunyi Medical College, Guizhou 563000, China Correspondence to: Xie, email: wanqiuniao@126.com Keywords: BCAR4, colon cancer, proliferation, Wnt/β-catenin Received: August 01, 2017 Accepted: September 04, Published: October 06, 2017 ABSTRACT BCAR4 (Breast Cancer Anti-Estrogen Resistance 4) is a long noncoding RNA that was...
Osteosarcoma (OS) is a primary malignant tumor of the bone, with tendency to metastasize early. Despite advances in treatment options, more than 30% patients develop distant metastases, and prognosis these metastases extremely poor. Celastrol has been demonstrated manifest multiple pharmacological activities, including induction apoptosis numerous types cancer cell lines. Our previous studies have also suggested that capable inducing human osteosarcoma cells via mitochondrial-dependent...
Aim: To investigate the association and prognostic value of ANKZF1 gene for survival in colorectal cancer, mechanism level alteration correlated signaling pathways is involved. Patients & methods: The Cancer Genome Atlas COREAD dataset was analyzed by bioinformatical investigation. Results: High expression associated with poor overall (hazard ratio [HR]: 2.094; 95% CI: 1.188–3.689; p = 0.011) recurrence-free (HR: 1.762; 1.021–3.042; 0.042) colon cancer. Bioinformatical analysis showed...
Enamel mineralization is accompanied by the release of protons into extracellular matrix, which buffered to regulate pH value in local microenvironment. The present study aimed investigate role microRNA 224 (miR-224) as a regulator SLC4A4 and CFTR, encoding key buffering ion transporters, modulating enamel mineralization. miR-224 was significantly downregulated ameloblasts differentiated, parallel with upregulation CFTR. Overexpression CFTR expression cultured human epithelial cells. A...
Metastasis is a crucial cause of the high mortality in patients with lung cancer. Long non-coding RNAs (lncRNAs) are emerging as important players development and progression human cancers. Here, we aimed to identify metastasis-associated lncRNA study its roles migration invasion cancer cells.We screened differentially expressed lncRNAs between high- low-metastatic cell lines by using microarray identified target TM4SF1-AS1. The effect TM4SF1-AS1 on was evaluated through wound healing...
Abstract Odontogenesis is accomplished by reciprocal signaling between the epithelial and mesenchymal compartments. It generally accepted that inductive mesenchyme capable of inducing odontogenic commitment both dental non-dental cells. However, duration this signal in developing whether adult pulp tissue maintains its capability remain unclear. This study investigated contribution growth factors to regulating potential mesenchyme. Human oral cells (OEs) were co-cultured with either human...
Multi-lineage differentiation of mesenchymal adult stem cells (m-ASCs) is crucial for tissue regeneration and accompanied with metabolism reprogramming, among which dental-pulp-derived m-ASCs has obvious advantage easy accessibility. Stem cell fate determination are closely related to status in microenvironment, could actively interact epigenetic modification. In recent years, glutamine-α-ketoglutarate (αKG) axis was proved be aging, tumorigenesis, osteogenesis etc., while its role still...
The purpose of this study is to investigate the influence mitochondrial respiratory chain complex I inhibition on radiosensitivity HepG2 cells. inhibitor rotenone was used inhibit activity cells before X-ray irradiation. cytotoxicity analyzed by MTT assay at various doses. Rotenone induced dissipation membrane potential and increase intracellular ROS production were observed. Intracellular ATP level determined using luciferin-luciferase kit. We further cell survival cycle distribution a...
BACKGROUND:Peutz-Jeghers syndrome (PJS) is an autosomal dominant genetic disease. It severely decreases patient quality of life and leads elevated cancer risk. Germline mutation LKB1 the leading cause familial PJS. MATERIAL AND METHODS:To characterize germline gene in Chinese sporadic PJS patients, 14 families, 5 250 healthy adults were collected genomic DNAs peripheral blood extracted. Mutation screenings performed using MLPA (multiplex ligation-dependent probe amplification), PCR, direct...
Abstract Background Autosomal recessive congenital ichthyosis ( ARCI ) is a group of genetically heterogeneous diseases. Mutations in transglutaminase TG ase) 1 gene TGM 1, OMIM 190195) have been implicated . However, little known about mutations the Chinese population, and no functional studies investigated biological effect mutant TGM1 on human epidermal keratinocytes (HaCaT) cells. Objectives To identify pathogenic two siblings with gain insight into consequences these mutations. Methods...
This study aimed to reveal the potential role of CARMN in odontogenic differentiation dental pulp cells (DPCs).