A5050458271- dental development and anomalies
- Bone and Dental Protein Studies
- Cancer-related gene regulation
- Plant Molecular Biology Research
- Mesenchymal stem cell research
- Epigenetics and DNA Methylation
- Oral microbiology and periodontitis research
- Dental Trauma and Treatments
- Periodontal Regeneration and Treatments
- Plant Gene Expression Analysis
- Plant Reproductive Biology
- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- Endodontics and Root Canal Treatments
- Animal Nutrition and Physiology
- Nitrogen and Sulfur Effects on Brassica
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Oral and Maxillofacial Pathology
- Salivary Gland Disorders and Functions
- Dental Health and Care Utilization
- MicroRNA in disease regulation
- Polysaccharides and Plant Cell Walls
- Plant Stress Responses and Tolerance
- Plant nutrient uptake and metabolism
Sichuan University
2016-2025
Ningbo No. 2 Hospital
2025
Xiamen University of Technology
2025
Palo Alto University
2024
Stanford University
2024
Peking University
2021-2024
State Key Laboratory of Oral Diseases
2014-2023
Zhengzhou University
2020-2023
West China Hospital of Sichuan University
2020-2023
Foshan University
2020-2022
Abstract TGF-β 1–3 are unique multi-functional growth factors that only expressed in mammals, and mainly secreted stored as a latent complex the extracellular matrix (ECM). The biological functions of adults can be delivered after ligand activation, mostly response to environmental perturbations. Although involved multiple pathological processes human body, exact roles maintaining stem cells tissue homeostasis have not been well-documented until recent advances, which delineate their given...
Neuroendocrine carcinomas, such as neuroendocrine prostate cancer and small-cell lung cancer, commonly have a poor prognosis limited therapeutic options. We report that ubiquitin carboxy-terminal hydrolase L1 (UCHL1), deubiquitinating enzyme, is elevated in tissues plasma from patients with carcinomas. Loss of UCHL1 decreases tumor growth inhibits metastasis these malignancies. maintains differentiation promotes progression by regulating nucleoporin, POM121, p53. binds, deubiquitinates,...
Dental caries is closely associated with the microbial dybiosis between acidogenic/aciduric pathogens and alkali-generating commensal bacteria colonized in oral cavity. Our recent studies have shown that arginine may represent a promising anti-caries agent by modulating composition an vitro consortium. However, effect of on microbiota has yet to be comprehensively delineated either clinical cohort or biofilm models better diversity Here, employing saliva-derived model, we demonstrated...
Degenerative disc disease (DDD) is associated with intervertebral degeneration of spinal instability. Here, we report that the cilia nucleus pulposus (NP) cells mediate mechanotransduction to maintain anabolic activity in discs. We found mechanical stress promotes transport parathyroid hormone 1 receptor (PTH1R) and enhances (PTH) signaling NP cells. PTH induces transcription integrin αvβ6 activate transforming growth factor (TGF)-β-connective tissue (CCN2)-matrix proteins cascade....
The pulpotomy with pulp capping is aimed at retaining vital reparative dentin formation. Vascular endothelial growth factor (VEGF) plays a crucial role in regeneration; however, its constant administrations the human body still problematic. Chitosan was widely studied as an effective carrier to deliver bioactive molecules regenerative medicine. In this study, we conducted chitosan/β-glycerophosphate (CS/β-GP) hydrogel VEGF-sustained release system and explored effects on dental stem cells...
Abstract Objectives The odontoblastic differentiation of dental pulp stem cells (DPSCs) contributes to tertiary dentin formation. Our previous study indicated that epiregulin (EREG) enhanced odontogenesis potential pulp. Here, we explored the effects EREG during DPSC differentiation. Methods changes in were detected DPSCs treated with recombinant human (rhEREG), receptor inhibitor gefitinib and short hairpin RNAs. was assessed ALP staining, activity assay, alizarin red S staining real‐time...
Abstract Objectives Oestrogen deficiency is an aetiological factor of postmenopausal osteoporosis (PMO), which not only decreases bone density in vertebrae and long but also aggravates inflammatory alveolar loss. Recent evidence has suggested the critical role gut microbiota osteoimmunology its influence on metabolisms. The present study aimed to evaluate therapeutic effects probiotics loss under oestrogen‐deficient condition. Materials Methods Inflammatory was established ovariectomized...
Abstract Background Epigenetic factors influence the odontogenic differentiation of dental pulp stem cells and play indispensable roles during tooth development. Some microRNAs can epigenetically regulate other epigenetic like DNA methyltransferases histone modification enzymes, functioning as epigenetic-microRNAs. In our previous study, microarray analysis suggested microRNA-93-5p (miR-93-5p) was differentially expressed bell stage in human germ. Prediction tools indicated that miR-93-5p...
Stem cells from the apical papilla (SCAPs) are important for formation and regeneration of root dentin. Here, we examined expression Notch signaling components in SCAPs investigated crosstalk between microRNA miR-34aand during cell differentiation. We found that human express NOTCH2, NOTCH3, JAG2, DLL3, HES1, tested relationship both differentiation miR-34a expression. NOTCH activation inhibited up-regulated miR-34a, whereas by directly targeting 3′UTR NOTCH2 HES1 mRNA suppressing N2ICD,...
Given that adult stem cells (ASCs) fuel homeostasis and healing by providing tissue-specific descendants, the fidelity of ASC fate determination is crucial for regeneration. Here, we established an epigenetic control epithelial via Ezh2/H3K27me3 was indispensable incisor Mechanistically, in homeostasis, H3K27me3 upstream occupies Sonic hedgehog (Shh) promoter to directly restrain Shh expression, thereby precisely confining expression. When injury occurred, substantially induced within inner...
Abstract Osteoporosis is a common disease that affects patient quality of life, especially among the elderly population. Although inflammation contributes significantly to osteoporosis, underlying mechanism unclear. In this study, we found tumor necrosis factor (TNF)-α, an inflammatory environment mimic, inhibits osteogenesis bone mesenchymal stem cells (BMSCs), induces miR-146a and decreases Smad4. Moreover, overexpression inhibited osteogenic ability BMSCs, whereas blocking partially...
Tooth eruption is a complex process requiring precise interaction between teeth and adjacent tissues. Molecular analysis demonstrates that bone remodeling plays an essential role during eruption, suggesting parathyroid hormone 1 receptor (PTH1R) gene mutation associated with disturbances in results primary failure of (PFE). Recent research reveals the function PTH1R signaling mesenchymal progenitors, whereas stem cells tooth remains incompletely understood. We investigated specific Prx1+...