A5080720100- Oral microbiology and periodontitis research
- Dental Erosion and Treatment
- Bone and Dental Protein Studies
- Dental materials and restorations
- Fluoride Effects and Removal
- Probiotics and Fermented Foods
- Ubiquitin and proteasome pathways
- Gut microbiota and health
- MicroRNA in disease regulation
- Periodontal Regeneration and Treatments
- Microtubule and mitosis dynamics
- Aluminum toxicity and tolerance in plants and animals
- RNA modifications and cancer
- Dental Health and Care Utilization
- RNA and protein synthesis mechanisms
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Cancer-related Molecular Pathways
- Salivary Gland Disorders and Functions
- Endoplasmic Reticulum Stress and Disease
- Antimicrobial Peptides and Activities
- Autophagy in Disease and Therapy
- Advanced Drug Delivery Systems
- Phytochemical compounds biological activities
- Atherosclerosis and Cardiovascular Diseases
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Beijing Hospital
2025
Zhengzhou University
2022-2024
East China Normal University
2024
Jilin University
2022
Bethune International Peace Hospital
2022
Karolinska Institutet
2018-2021
DKFZ-ZMBH Alliance
2016-2019
Heidelberg University
2016-2019
German Cancer Research Center
2019
Coordinated translation initiation is coupled with cell cycle progression and growth, whereas excessive ribosome biogenesis often lead to tumor transformation survival. Hepatocellular carcinoma (HCC) among the most common aggressive cancers worldwide generally displays inherently high resistance chemotherapeutic drugs. We found that RACK1, receptor for activated C-kinase 1, was highly expressed in normal liver frequently upregulated HCC. Aberrant expression of RACK1 contributed vitro...
Chaperone-mediated autophagy (CMA) is a lysosomal degradation pathway of select soluble proteins. Nearly one-third the proteins are predicted to be recognized by this pathway, yet only minor fraction proteome has been identified as CMA substrates in cancer cells. Here, we undertook quantitative multiplex mass spectrometry approach study isolated lysosomes cells during CMA-activated conditions. By integrating bioinformatics analyses, and categorized multiple cellular pathways that were...
Abstract Objective Accumulating evidence for differential expression of microRNA-224 (miR-224) in various types human cancer suggests that it may be play a crucial role tumor biology. The previous microarray detection also shown miR-224 was one miRNAs with significant upregulation cervical tissues relative to adjacent normal tissues. However, little is known about the function cancer. aim this study investigate clinical significance Methods MiR-224 126 pairs fresh and measured by real-time...
Dental caries is closely associated with the microbial dybiosis between acidogenic/aciduric pathogens and alkali-generating commensal bacteria colonized in oral cavity. Our recent studies have shown that arginine may represent a promising anti-caries agent by modulating composition an vitro consortium. However, effect of on microbiota has yet to be comprehensively delineated either clinical cohort or biofilm models better diversity Here, employing saliva-derived model, we demonstrated...
To investigate the competition between probiotics in bio-yogurt and periodontal pathogens vitro.The antimicrobial activity of was studied by agar diffusion assays, using eight species putative a 'protective bacteria' as indicator strains. Four probiotic bacterial (Lactobacillus bulgaricus, Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium) were isolated from yogurt used to rate competitive exclusion pathogens.Fresh inhibited all included this work, showing inhibition...
Autophagic pathways are regulated mechanisms that play important roles in lysosome-mediated cellular degradation. Yet, the contribution of different autophagic lysosomal targeting, and characterization extent specificity their degradome remains largely uncharacterized. By undertaking a multiplex quantitative mass spectrometry approach, we have previously analyzed proteome during chaperone-mediated autophagy (CMA)-stimulated conditions cancer cells. Here, extended our bioinformatics analysis...
The Rac1/Cdc42 effector, p21-activated kinase (PAK), is activated by various signaling cascades, including receptor-tyrosine kinases and integrins, regulates a number of processes such as cell proliferation motility. PAK activity has been shown to be required for maximal activation the canonical RAF-MEK-MAPK cascade, possibly because co-activation RAF MEK. Here we have that trihydrophobin 1 (TH1), originally identified negative regulator A-RAF kinase, also interacted with PAK1 in cultured...
Deubiquitinating enzymes (DUBs) are linked to cancer progression and dissemination, yet less is known about their regulation impact on epithelial-mesenchymal transition (EMT).An integrative translational approach combining systematic computational analyses of The Cancer Genome Atlas cohorts with CRISPR genetics, biochemistry immunohistochemistry methodologies identify assess the role human DUBs in EMT.We a previously undiscovered biological function STAM-binding protein like 1 (STAMBPL1)...
RecQ-like helicase 4 (RECQL4) is mutated in patients suffering from the Rothmund–Thomson syndrome, a genetic disease characterized by premature aging, skeletal malformations, and high cancer susceptibility. Known roles of RECQL4 DNA replication repair provide possible explanation chromosome instability observed patient cells. Here, we demonstrate that microtubule-associated protein (MAP) localizing to mitotic spindle. depletion M-phase–arrested frog egg extracts does not affect spindle...
Dental caries is a chronic progressive disease occurring in the tooth hard tissue due to multiple factors, which bacteria are initial cause. Both Streptococcus mutans and sanguinis main members of oral biofilm. Helicobacter pylori may also be detected dental plaque, playing an important role development caries.The aim this study was investigate effect H. culture supernatant on S. dual-species biofilm evaluate its potential ability affecting health.The single-species measured by colony...
To evaluate the effect of Nidus Vespae extract and chemical fractions on viability architecture Streptococcus mutans biofilms.The raw material was first extracted using 95% ethanol/water. Subsequent were prepared from this cyclohexane/ethyl acetate, petroleum ether/ethyl acetate chloroform/methanol. The biomass dry weight total protein samples treated with significantly less than those vehicle control (P < 0.05). Biofilms also resulted in lower percentage polysaccharide composition. pH...