A5064976903- Endodontics and Root Canal Treatments
- Oral microbiology and periodontitis research
- Dental materials and restorations
- Dental Radiography and Imaging
- Bone Tissue Engineering Materials
- Dental Health and Care Utilization
- Bone Metabolism and Diseases
- Dental Implant Techniques and Outcomes
- FOXO transcription factor regulation
- Orthopaedic implants and arthroplasty
- Hepatocellular Carcinoma Treatment and Prognosis
- Dental Erosion and Treatment
- Autophagy in Disease and Therapy
- Antifungal resistance and susceptibility
- Probiotics and Fermented Foods
- Cellular Mechanics and Interactions
- Titanium Alloys Microstructure and Properties
- Cancer Mechanisms and Therapy
- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Streptococcal Infections and Treatments
- Metabolomics and Mass Spectrometry Studies
- Drilling and Well Engineering
- Immune Response and Inflammation
- Laser Applications in Dentistry and Medicine
State Key Laboratory of Oral Diseases
2010-2025
Sichuan University
2015-2025
Hunan Normal University
2025
Shenzhen University Health Science Center
2022-2024
Central South University
2022-2024
Xiangya Hospital Central South University
2022-2024
Guangdong Pharmaceutical University
2023
National Clinical Research
2022
Stomatology Hospital
2009-2022
West China Hospital of Sichuan University
2008-2022
Abstract Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide + (NAD )-dependent deacetylase located in the mitochondria that may regulate oxidative stress, catabolism and ATP production. Accumulating evidence has recently revealed SIRT3 plays its critical roles cardiac fibrosis, myocardial fibrosis even heart failure (HF), through deacetylation modifications. Accordingly, discovery of activators elucidating their underlying mechanisms HF should be urgently...
Abstract Branched-chain α-keto acid dehydrogenase kinase (BCKDK), the key enzyme of branched-chain amino acids (BCAAs) metabolism, has been reported to promote colorectal cancer (CRC) tumorigenesis by upregulating MEK-ERK signaling pathway. However, profile BCKDK in metastatic (mCRC) remains unknown. Here, we report a novel role mCRC. is upregulated CRC tissues. Increased expression was associated with metastasis and poor clinical prognosis patients. Knockdown decreased cell migration...
Sirtuin-3 (SIRT3) is an NAD+-dependent protein deacetylase localized primarily in the mitochondria with many links to different types of human cancers. Autophagy, which a highly conserved lysosomal degradation process eukaryotic cells, has been recently reported be positively regulated by SIRT3 cancer; therefore, activating SIRT3-modulated autophagy may promising strategy for drug discovery. In this study, we discovered small-molecule activator compound 33c (ADTL-SA1215) specific activity...
Abstract ULK1, the upper-most protein of ULK1 complex, is emerging as a crucial node in autophagy induction. However, regulation not fully understood. In this study, we identified TOPK (T-LAK cell-originated kinase), an oncokinase, novel upstream kinase to phosphorylate ULK1. We found that could directly bind with and at Ser469, Ser495, Ser533. The phosphorylation Ser533 by decreased activity stability addition, want examine initiation because reduction reduces occurrence autophagy....
To investigate the involvement of IL-6/STAT3 signaling pathway activation in macrophage polarization and bone destruction related to apical periodontitis (AP) stimulated by Porphyromonas gingivalis.Macrophage polarization, expression, presence P. gingivalis were detected human AP tissues via RT-qPCR, western blotting, immunohistochemistry staining. Murine marrow derived macrophages isolated cultured with W83 vitro, levels IL-6 STAT3 phosphorylation, or without selective phosphorylation...
Acetabular polyethylene components were quantitatively analyzed for the presence of third body particles from 38 consecutively retrieved components. Backscattered electron imaging and correlated energy dispersive xray analysis used assessments. Retrievals divided into 4 groups based on methods fixation metal alloy types: 8 hydroxyapatite coated, 6 cobalt chrome porous 17 titanium 7 cemented implants evaluated. The backscattered data showed that coated had larger than did group. group 51 ± 52...
Mechanical stress has been considered to be an important factor in bone remodeling and recent publications have shown that mechanical can regulate the direction of stem cell differentiation. The exact mechanobiological effects pressure on initial osteodifferentiation mesenchymal cells (MSCs) not determined. These mechanisms may both biological responses during orthodontic tooth movement development new strategies for tissue engineering. We investigated static (23 kPa) or dynamic (10-36 kPa...
Sorafenib and transarterial chemoembolization (TACE) are recommended therapies for advanced hepatocellular carcinoma (HCC), but their combined efficacy remains unclear. Between August 2004 November 2014, 104 patients with BCLC stage B/C HCC were enrolled at the Affiliated Tumor Hospital of Guangxi Medical University, China. Forty-eight treated sorafenib alone (sorafenib group) 56 TACE plus (TACE + group). Baseline demographic/clinical data collected. The primary outcomes median overall...
Bromodomain-containing protein 4 (BRD4) is an attractive epigenetic target in human cancers. Inhibiting the phosphorylation of BRD4 by casein kinase 2 (CK2) a potential strategy to overcome drug resistance cancer therapy. The present study describes synthesis multiple BRD4–CK2 dual inhibitors based on rational design, structure–activity relationship, and vitro vivo evaluations, 44e was identified possess potent balanced activities against (IC50 = 180 nM) CK2 230 nM). In experiments show that...
Rapid and nondestructive estimation of leaf SPAD values is crucial for monitoring the effects cadmium (Cd) stress in rice. To address issue low accuracy value models due to loss spectral information existing studies, a new model, which combines sensitive vegetation indices (VIss) fractional order differential characteristic bands (FODcb), proposed this study. validate effectiveness three scenarios, with no Cd contamination, 1.0 mg/kg 1.4 were set up. Leaf reflectance measured during critical...
Background Caries is one of the most common diseases worldwide, and Streptococcus mutans considered to be primary cariogenic pathogen dental caries. Sodium houttuyfonate (SH) has showed potential antibacterial effects, however, its actions mechanisms on S. cariogenicity remain unclear need further study.
The main component of natural teeth was determined many years ago as calcium phosphate, mostly in the form hydroxyapatite with different crystallites. In past, method used tooth crystal investigation has been mainly powder X-ray diffraction analysis, but this its drawbacks, i.e. destruction structure and difficulty examining preferred orientation layers tooth. During last century, microzone on surface carried out, but, technology less sophisticated, results obtained were not very detailed....