A5087817142- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Autophagy in Disease and Therapy
- Cannabis and Cannabinoid Research
- Traditional and Medicinal Uses of Annonaceae
- Phytochemistry and Bioactive Compounds
- Computational Drug Discovery Methods
- Microbial Natural Products and Biosynthesis
- Biological and pharmacological studies of plants
- Phytochemical compounds biological activities
- Bioactive natural compounds
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Cancer-related molecular mechanisms research
- Natural Antidiabetic Agents Studies
- Cardiac Fibrosis and Remodeling
- Liver Disease Diagnosis and Treatment
- Calcium signaling and nucleotide metabolism
- GABA and Rice Research
- Blood Pressure and Hypertension Studies
- Metabolomics and Mass Spectrometry Studies
- Cancer Mechanisms and Therapy
- Cancer, Stress, Anesthesia, and Immune Response
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
Second Affiliated Hospital of Nanchang University
2024-2025
Nanchang University
2023-2025
Jiangxi Provincial Academy of Medical Sciences
2024-2025
National Clinical Research Center for Digestive Diseases
2025
Shenyang Pharmaceutical University
2015-2024
State Key Laboratory of Biotherapy
2017-2022
Sichuan University
2017-2022
Southwest Jiaotong University
2021
Liaoning University of Traditional Chinese Medicine
2020
Sun Yat-sen University
2019
Abstract Sirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide + (NAD )-dependent deacetylase located in the mitochondria that may regulate oxidative stress, catabolism and ATP production. Accumulating evidence has recently revealed SIRT3 plays its critical roles cardiac fibrosis, myocardial fibrosis even heart failure (HF), through deacetylation modifications. Accordingly, discovery of activators elucidating their underlying mechanisms HF should be urgently...
This study aimed to explore potential new drugs in the treatment of ischemic stroke by Connectivity Map (CMap) and determine role luteolin on according its effects matrix metalloproteinase-9 (MMP9) PI3K/Akt signaling pathway. Based published gene expression data, differentially expressed genes were obtained microarray analysis. Potential compounds for therapy CMap Cytoscape set enrichment analysis (GSEA) used discover pathways connected stroke. Cell apoptosis viability were, respectively,...
Abstract Objectives Triple negative breast cancer ( TNBC ) is a complex and intrinsically aggressive tumour with poor prognosis, the discovery of targeted small‐molecule drugs for treatment still remains in its infancy. In this study, we aimed to discover agent illuminate potential mechanisms. Materials methods Cell viability was detected by using methylthiazoltetrazolium (MTT) assay. Electron microscopy, GFP ‐ LC 3 transfection, monodansylcadaverine staining apoptosis assay were performed...
Acute cerebral infarction (ACI) is the most common type of acute cerebrovascular diseases resulting in high rate death and disability. Numerous evidences show that inflammation leading cause ischemic brain injury, thus anti-inflammatory therapy an attractive candidate for damage. Eicosapentaenoic acid (EPA) exerts activity lots human inflammatory diseases, whereas its effect ACI left to elucidate. Nlpr3−/− mice, Gpr40−/−; Gpr120−/− mice with right middle artery occlusion (MCAO) were used...
There is a paucity of prior research on residual cholesterol (RC) and hyperuricemia, it remains unclear whether body mass index (BMI) functions as mediating factor between them or intensifies lipid metabolic dysregulation, thereby elevating the risk hyperuricemia. This study aims to investigate BMI mediates association RC well interaction joint effect cross-sectional study, involving total 14,218 hypertensive patients. Exposure factors include BMI. The outcome was Hyperuricemia, defined...
Abstract Objectives Autophagy, a highly conserved lysosomal degradation process in eukaryotic cells, can digest long‐lived proteins and damaged organelles through vesicular trafficking pathways. Nowadays, mechanisms of autophagy have been gradually elucidated thus the discovery small‐molecule drugs targeting has always drawing much attention. So far, some autophagy‐related web servers available online to facilitate scientists obtain information relevant conveniently, such as HAD b, CTLPS...
Seven new flavonoid glycosides (1-7), matteflavosides A-G, together with 12 known flavonoids (8-19) were isolated from the rhizomes of Matteuccia struthiopteris (L.) Todar. Their structures established via analyses extensive spectroscopic data. All compounds evaluated for their anti-influenza virus (H1N1) activity using neuraminidase inhibition assay. The results showed that compound 7 exhibited significant inhibitory against H1N1 influenza an EC50 value 6.8 ± 1.1 μM and SI 34.4, 8 17...
Four pairs of stereoisomeric indole alkaloids, (±)-baphicacanthcusines A–D (1–4), and one new alkaloid, baphicacanthcusine E (5), together with nine known compounds were identified from the leaves Baphicacanthus cusia. (±)-1 -2 possess an unprecedented skeleton in which two moieties are bridged by a phenylpropane unit. (±)-3 represents first natural dispiro-oxazolidinone bisoxindoles. The absolute configurations 1–5 assigned based on quantum chemical calculations, including calculated shift...
Abstract Five new 12-membered resorcylic acid lactone derivatives, penicimenolides A-E ( 1–5 ), one ring-opened derivative penicimenolide F 6 ) and six known biogenetically related derivatives 7–12 were isolated from the culture broth of a strain Penicillium sp. (NO. SYP-F-7919), fungus obtained rhizosphere soil Panax notoginseng collected Yunnan province China. Their structures elucidated by extensive NMR analyses, modified Mosher’s method, chemical derivatization single crystal X-ray...
This study aimed to investigate the chemical components and potential health benefits of fruits
The effective therapeutic approach of cerebral infarction is limited because its underlying complexity. Recently, multiple long noncoding RNAs (lncRNAs) have been identified in the pathogenesis infarction. Here, current study aims to explore interaction among lncRNA cyclin-dependent kinase inhibitor-2B–antisense RNA 1 (CDKN2B-AS1), transcription factor B-cell lymphoma/leukemia 11A (BCL11A), and MAPKK (MAP4K1) further investigate whether they affect progression. expression CDKN2B-AS1, BCL11A,...
Myocardial fibrosis is well-known to be the aberrant deposition of extracellular matrix (ECM), which may cause cardiac dysfunction, morbidity, and death. Traditional Chinese medicine formula Si-Miao-Yong-An Decoction (SMYAD), used clinically in cardiovascular diseases has been recently reported able resist myocardial fibrosis. The anti-fibrosis effects SMYAD have evaluated; however, its intricate mechanisms remain clarified. Here, we found that treatment reduced injury collagen fiber could...