A5049089817- Mesenchymal stem cell research
- Bone and Dental Protein Studies
- Cancer-related molecular mechanisms research
- dental development and anomalies
- Bone Tissue Engineering Materials
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Bone Metabolism and Diseases
- Periodontal Regeneration and Treatments
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
- MicroRNA in disease regulation
- Signaling Pathways in Disease
- Hedgehog Signaling Pathway Studies
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Genomics and Chromatin Dynamics
- Endodontics and Root Canal Treatments
- Bone health and treatments
- Dental Erosion and Treatment
- Graphene and Nanomaterials Applications
- Dental Implant Techniques and Outcomes
Sichuan University
2016-2025
State Key Laboratory of Oral Diseases
2013-2025
West China Hospital of Sichuan University
2021-2024
Stomatology Hospital
2018-2023
National Clinical Research
2023
Augusta University
2023
Exploring high-efficiency reactive oxygen species (ROS)-elimination materials is of great importance for combating oxidative stress in diverse diseases, especially stem-cell-based biotherapeutics. By mimicking the FeN active centers natural catalase, here, an innovative concept to design ROS-elimination artificial biocatalysts with Ru catalytic stem-cell protection reported. The experimental studies and theoretical calculations have systematically disclosed activity merits structure...
Abstract Background Controlling the adipo-osteogenic lineage commitment of bone marrow mesenchymal stem cell (BMSC) in favor osteogenesis is considered a promising approach for regeneration and repair. Accumulating evidence indicates that oxidative phosphorylation (OXPHOS) involved regulating fate decisions. As an essential cofactor OXPHOS, nicotinamide adenine dinucleotide (NAD) has been shown to correlate with differentiation cells. However, whether NAD manipulates BMSC through OXPHOS...
Abstract Previous research indicates that knocking out absent, small, or homeotic-like (Ash1l) in mice, a histone 3 lysine 4 (H3K4) trimethyltransferase, can result arthritis with more severe cartilage and bone destruction. Research has documented the essential role of Ash1l stem cell fate decision such as hematopoietic cells progenitors keratinocytes. Following up on those insights, our seeks to document function skeletal formation, specifically whether it controls mesenchymal progenitor...
Significance Notch is a critical regulator of skeletal development, but its role in remodeling the adult skeleton unclear. Using genetically modified mice, we show that stimulates mineralization by bone-building osteoblasts. Thus, overexpression intracellular domain mice results an increase bone mass, prevents loss following ovariectomy and during aging, promotes fracture healing. therefore potential therapeutic target for conditions loss, including osteoporosis.
Abstract As a profoundly anabolic regulator of bone, Wnt7b is well acknowledged to enhance osteoblast activities. Here, we report that bone marrow mesenchymal stem cells (BMSCs) are another important population responding Wnt7b. In this study, systematically investigated the in vivo role BMSCs using transgenic mice, high-throughput RNA-seq, immunohistochemistry, RT-qPCR, and situ hybridization. These methods led us uncover Sox11 induced via BMSCs. Colony formation assay, flow cytometry, EdU...
Given that adult stem cells (ASCs) fuel homeostasis and healing by providing tissue-specific descendants, the fidelity of ASC fate determination is crucial for regeneration. Here, we established an epigenetic control epithelial via Ezh2/H3K27me3 was indispensable incisor Mechanistically, in homeostasis, H3K27me3 upstream occupies Sonic hedgehog (Shh) promoter to directly restrain Shh expression, thereby precisely confining expression. When injury occurred, substantially induced within inner...
Geriatric oral health care encounters significant challenges with the increase in proportion of older individuals. Age-related changes dentition, muscles, and joints result a decline objective masticatory function, subjective restoration requirements, acceptability among elderly population, individual variations influenced by systemic health. Considering functional adaptability stomatognathic conditions, economics other factors, authors believe that it should not be limited to conventional...
The extracellular matrix microenvironment of bone tissue comprises several physiological cues. Thus, artificial substitute materials with a single cue are insufficient to meet the demands for defect repair. Regeneration critical-size defects remains challenging in orthopedic surgery. Intrinsic viscoelastic and piezoelectric cues from collagen fibers play crucial roles accelerating regeneration, but scaffolds or implants providing integrated have seldom been reported. In this study, it is...
Abstract Recent studies have proven that long noncoding RNAs (lncRNAs) exhibit regulatory functions of both DNA damage response (DDR) and endoplasmic reticulum (ER) stress. Herein, ER stress‐induced lncRNA transcriptomic changes are reported in human oral squamous cell carcinoma (OSCC) cells a novel HITTERS ( H ERPUD1 i n t ronic ranscript s tress) is identified as the most significantly upregulated lncRNA. It shown nucleus‐located including two transcript variants. lacks an independent...
SIRT6 is a NAD-dependent histone 3 deacetylase. null mice have been reported suffering osteopenia. However, the role of in bone resorption still not well understood. In this study, we focused on osteoclast. We performed histological analysis femur, spine, alveolar and even tail mutant mice, found mass sharply decreased while osteoclast activity significantly increased. These phenotypes were further demonstrated by differentiation cell-cultures with TRAP staining Pit Resorption Assay. next...
Abstract Hippo‐independent YAP dysfunction has been demonstrated to cause chronological aging of stromal cells by impairing the integrity nuclear envelope (NE). In parallel with this report, we uncover that activity also controls another type cellular senescence, replicative senescence in vitro expansion mesenchymal (MSCs), but event is Hippo phosphorylation‐dependent, and there exist NE integrity‐independent downstream mechanisms YAP. Specifically, phosphorylation causes reduced...
Abstract Precise orchestration of cell fate determination underlies the success scaffold-based skeletal regeneration. Despite extensive studies on mineralized parenchymal tissue rebuilding, regenerating and maintaining undifferentiated mesenchyme within calvarial bone remain very challenging with limited advances yet. Current knowledge has evidenced indispensability rebuilding suture mesenchymal stem niches to avoid severe brain or even systematic damage. But date, absence promising...
Skeletal stem cells (SSCs) fuel adult bone with stemness resources to maintain homeostasis and support regeneration, which depends on the precise determination of osteogenic lineage commitment SSCs. In this study, using Cre-loxP reporter tracking, we identified characterized a population NFATc1+ SSCs in regeneration. Pre-existing are involved early callus formation. Subsequently, these produce osteolineage descendants subsequent stages The Ca2+-triggered transcriptional activity NFATc1...
The adaptor protein NUMB is involved in asymmetric division and cell fate determination recognized as an antagonist of Notch. Previous studies have proved that Notch activation osteoblasts contributes to a high bone mass. In this study, however, osteopenic phenotype was found 9-week-old mice using osteoblastic specific Col1a1-2.3-Cre ablate both Numb its homologue Numbl . trabecular mass decreased dramatically while the cortical unaffected. Here, signal not activated, tensin deleted on human...