A5101859507- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Periodontal Regeneration and Treatments
- MicroRNA in disease regulation
- dental development and anomalies
- Bone Metabolism and Diseases
- Mesenchymal stem cell research
- Genomics and Chromatin Dynamics
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Bone and Dental Protein Studies
- Chromatin Remodeling and Cancer
- Circular RNAs in diseases
- Bone Tissue Engineering Materials
- Extracellular vesicles in disease
- Bone health and treatments
- Blood Pressure and Hypertension Studies
- Hedgehog Signaling Pathway Studies
- Dental Implant Techniques and Outcomes
State Key Laboratory of Oral Diseases
2018-2024
University of Dental Medicine
2024
National Clinical Research Center for Digestive Diseases
2024
Stomatology Hospital
2024
Jinan University
2023
Southern University of Science and Technology
2023
Sichuan University
2018-2022
Abstract Background Although there is numerous evidence on the epidemiological risk factors for insulin resistance (IR)-related metabolic diseases, still insufficient to explore non-linear association of Atherogenic Index Plasma (AIP) with IR. Therefore, we aimed elucidate relationship between AIP and IR type 2 diabetes (T2D). Methods This cross-sectional study was conducted in National Health Nutrition Survey (NHANES) from 2009 2018. A total 9,245 participants were included study. The...
Abstract Previous research indicates that knocking out absent, small, or homeotic-like (Ash1l) in mice, a histone 3 lysine 4 (H3K4) trimethyltransferase, can result arthritis with more severe cartilage and bone destruction. Research has documented the essential role of Ash1l stem cell fate decision such as hematopoietic cells progenitors keratinocytes. Following up on those insights, our seeks to document function skeletal formation, specifically whether it controls mesenchymal progenitor...
The enhancer of zeste homolog 2 (EZH2) is a catalytic subunit PRC2 (polycomb repressor complex 2). It mediates gene silencing via methyltransferase activity and involved in the determination cell lineage. However, function EZH2 underlying mechanisms by which it affects differentiation human dental pulp (hDPC) have remained underexplored. In this research, we found that expression decreased during mineralization hDPCs, with attenuated H3K27me3 (trimethylation on lysine 27 histone H3)....
Teriparatide is the most widely prescribed bone anabolic drug in world, but its cellular targets remain incompletely defined. The Gli1
Osteoclasts are multinucleated giant cells. Fusion is an essential element in the formation of osteoclasts. However, exact cellular events and mechanisms remain largely unknown because limited insufficient methods for observing fusion process. In this work, a fluorescence reporter strategy was established to monitor osteoclast fusion. After fusing with cells expressing Cre recombinase, those double switch its expression from red green fluorescent protein. The effect RANKL PTH on were both...
Bone contains multiple pools of skeletal stem/progenitor cells (SSPCs), and SSPCs in periosteal compartments are known to exhibit higher regenerative potential than those BM endosteal compartments. However, the vivo identity hierarchical relationships (P-SSPCs) remain unclear due a lack reliable markers distinguish P-SSPCs. Here, we found that mesenchymal progenitor (P-MPs) periosteum can be identified based on Postn-CreERT2 expression. Postn-expressing subpopulation produces osteolineage...