A5008329236- Magnesium Alloys: Properties and Applications
- Mesenchymal stem cell research
- Aluminum Alloys Composites Properties
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Bone and Dental Protein Studies
- Periodontal Regeneration and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Dental Health and Care Utilization
- Oral microbiology and periodontitis research
- Neurogenesis and neuroplasticity mechanisms
- dental development and anomalies
- Power Line Inspection Robots
- Phagocytosis and Immune Regulation
- Fluid Dynamics and Heat Transfer
- Cholinesterase and Neurodegenerative Diseases
- Electrospun Nanofibers in Biomedical Applications
- Dental Trauma and Treatments
- MRI in cancer diagnosis
- Trauma Management and Diagnosis
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Combustion and flame dynamics
Shandong Provincial Hospital
2024-2025
Shandong University
2023-2025
Sichuan University
2017-2024
Qilu Hospital of Shandong University
2024
Shandong Tumor Hospital
2024
Shandong First Medical University
2024
Shandong Provincial QianFoShan Hospital
2024
Weifang Medical University
2024
AbbVie (United States)
2024
Beijing Institute of Technology
2017-2021
The identification of somatic driver mutations in cancer has enabled therapeutic advances by identifying drug targets critical to disease causation. However, such genomic discoveries oncology have not translated into for non-cancerous since point a single cell would be unlikely cause non-malignant disease. An exception this occur if the mutation happened early enough development present large percentage tissue's cellular population. We sought identify existence occurring human ascertaining...
The pulpotomy with pulp capping is aimed at retaining vital reparative dentin formation. Vascular endothelial growth factor (VEGF) plays a crucial role in regeneration; however, its constant administrations the human body still problematic. Chitosan was widely studied as an effective carrier to deliver bioactive molecules regenerative medicine. In this study, we conducted chitosan/β-glycerophosphate (CS/β-GP) hydrogel VEGF-sustained release system and explored effects on dental stem cells...
Abstract Background Epigenetic factors influence the odontogenic differentiation of dental pulp stem cells and play indispensable roles during tooth development. Some microRNAs can epigenetically regulate other epigenetic like DNA methyltransferases histone modification enzymes, functioning as epigenetic-microRNAs. In our previous study, microarray analysis suggested microRNA-93-5p (miR-93-5p) was differentially expressed bell stage in human germ. Prediction tools indicated that miR-93-5p...
To develop and evaluate the performance of a noninvasive radiomics combined model based on preoperative bi-parametric MRI to assess biochemical recurrence (BCR) risk factors predict free survival in PCa patients. Pretreatment bp-MRI clinicopathology data 666 (discovery cohort, 545; test 121) patients from four centers between January 2015 March 2023 were retrospectively included. BCR, extracapsular extension (ECE), pelvic lymph node metastasis (PLNM), Gleason Grade group (GG), pred-BCR,...
Dentinogenesis imperfecta (DGI), Shields type-II is an autosomal dominant genetic disease which severely affects the function of patients' teeth. The dentin sialophosphoprotein (DSPP) gene considered to be pathogenic DGI-II. In this study, a DGI-II family with novel DSPP mutation were collected, functional characteristics DGI cells and clinical features analyzed better understand genotype-phenotype relationship disease.Clinical data whole exome sequencing (WES) was conducted, Sanger used...
Abstract Objectives Platinum-based chemotherapy as first-line treatment have shown promising results against tumors in thymic carcinoma (TC). However, clinical benefit has been limited to a small proportion of patients. We developed and validated combined radiomics model predict progressive disease (PD) patients suffering from TC following chemotherapy. Methods Patients receiving platinum-based four centers Shandong, China, were retrospectively included (n = 134); 93 41 entered into the...
Abstract Randomized controlled trials (RCTs) are the gold standard for evaluating drug safety and efficacy in settings, but they have limited generalizability due to their focus on selective homogeneous populations. Real-world-data (RWD), collected from larger more varied patient populations, can address inherent limitations of RCTs aid clinical trial design approval. However, with challenges RWD, unlocking its full potential tumor target biomarker identification validation demands...
Abstract Natural killer (NK) cell redirecting therapies are emerging as promising “off the shelf” treatments for cancer without safety issues associated with T directed therapies. ABBV-303 is a novel c-Met targeted multispecific NK engager based on Dragonfly Therapeutics’ TriNKET® technology. includes three functional arms: (1) binding scFv ABT-700, common to c-Met-targeting antibody-drug conjugates ABBV-400 and Teliso-V; (2) Fab arm that binds NKG2D, stimulatory receptor expressed by cells...
Vascular leakage has been proven to play a critical role in the incidence and development of explosive pulmonary barotrauma. Quantitatively investigated present study was severity vascular gradient blast injury series, as well ultrastructural evidence relating leakage.One hundred adult male New Zealand white rabbits were randomly divided into 5 groups according distance from detonator (10 cm, 15 20 30 sham control). Value monitored by radioactive 125I-albumin labeling method. Pathological...
Polyurethane foam has the properties of energy absorption and mitigating impact, it been used in internal protection head cap cylindrical objects as cushion material, its theory simulation widely discussed by domestic foreign scholars, but little experimental research is involved. In this paper, a dynamic loading water-entry impact experiment was designed for polyurethane plastics with different densities. addition, ANSYS/LS-DYNA finite element analysis software to simulate process materials...
Firstly, the stability of slope need to determine mechanical parameters rock mass such as deformation modulus, Poissons ratio, cohesion and internal friction angle, etc. For intact rocks, mentioned before are easy determined. While is controlled by intensity. Therefore, how structure key analyze mass. This paper intends set below some extra-large bridge research object use numerical calculation mechanics plane on basis sample test results.
The principle of an ultrasonic distance measurement system is introduced. adopts non-contact method and it consists signal generator, echo receiver circuit, microcontroller, time sequential logic control target detection temperature RS-485 serial interface sensor its driver etc. results show that the has high precision within measuring range from 20cm to 15m.
Deciduous teeth are the first dentition of humans and play an important role in children's physical mental development. Dental caries one most common oral diseases children. According to data World Health Organization, 60%-90% school children worldwide develop dental caries. In China, primary feature high incidence low rate visits. Without timely treatment, deep lesions can lead defect, pulpitis, apical periodontitis, maxillofacial space infection. Moreover, premature loss deciduous cause...
Magnesium alloy has been considered as a revolutionary biodegradable material, but the fast degradation limits its development. A permanganate conversion coating for AZ31B magnesium prepared, in order to improve anti-corrosion property. The morphology and composition of were characterized with scanning electron microscopy (SEM), X-ray diffraction (XRD) energy dispersion spectroscopy (EDS), which showed that was 40-170μm thickness, net-like micro-cracks, tightly combined matrix. main...
Mg and its alloys draw more attentions to be used as biodegradable medical materials. But the rapid degradation of those materials limits their clinical applications. In this article, a phosphate coating was prepared on AZ31B magnesium alloy improve anti-corrosion property. Morphology, composition corrosion resistance were studied. The SEM research showed that composed rod-like phosphates with small amount random distributed micro-voids approximately10-20μm in thickness. XRD analysis...
Calcium sulfate/hydroxyl apatite whiskers composite is possible to be used as bone graft substitute, for its biocompatibility, controllable degradation, and suitable mechanical properties. In this study, calcium whisker composites were fabricated characterized. The characteristics of the assessed by means scanning electron microscopy (SEM), X-ray diffraction (XRD) immersing testing techniques. prepared in article have been confirmed ideally biodegradable implants.