A5101575231- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Intensive Care Unit Cognitive Disorders
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Alzheimer's disease research and treatments
- Anesthesia and Sedative Agents
- Nuclear Receptors and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Spaceflight effects on biology
- Epigenetics and DNA Methylation
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Electron Spin Resonance Studies
- Cardiac Ischemia and Reperfusion
- Andrographolide Research and Applications
- Cellular transport and secretion
- S100 Proteins and Annexins
- Sirtuins and Resveratrol in Medicine
- Cancer, Stress, Anesthesia, and Immune Response
- Traumatic Brain Injury and Neurovascular Disturbances
- Peroxisome Proliferator-Activated Receptors
Beijing Institute of Technology
2016-2024
Aerospace Center Hospital
2022-2024
Hebei Medical University
2004-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2022-2024
Wenzhou Medical University
2022-2024
Peking University
2023
Northwest University
2022
McLean Hospital
2017-2021
Third Hospital of Hebei Medical University
2010-2019
Lanzhou University
2019
Abstract The hippocampal CA3 contributes to spatial working memory (SWM), but which stage of SWM the neurons act on and whether lateralization function occurs in is also unknown. Here, we reveal increased neural activity both sample choice phases SWM. Left (LCA3) show higher sensitivity phase during correct versus error trials compared with right (RCA3) neurons. LCA3 initiates firing prior RCA3 phase. Optogenetic suppression pyramidal disrupts only Furthermore, discover that parvalbumin (PV)...
Myocardial ischemia/reperfusion injury (IRI) has long been identified to be a contributor adverse cardiovascular outcomes following myocardial ischemia, cardiac surgery or circulatory arrest. This study aims investigate the effects of microRNA (miR-370) targeting perilipin-5 (PLIN5) in mice sevoflurane anesthetic preconditioning (SAP). A mouse model left ventricular IRI was established, followed by evaluation infarction size and function determine SAP. The underlying regulatory mechanisms...
The mechanisms of the transplantation neural stem cells (NSCs) in treatment Alzheimer's disease remain poorly understood. In this study, NSCs were transplanted into hippocampal CA1 region rTg (tau P301L) 4510 mouse model, a tauopathy model that is thought to reflect tau pathology associated with disease. results revealed NSC reduced abnormal aggregation tau, resulting significant improvements short-term memory mice. Compared wild-type and phosphate-buffered saline (PBS)-treated mice, mice...
Addiction to cocaine is associated with dysfunction of the dopamine mesocortical system including impaired dopamine-2 receptor (D2r) signaling. However, effects chronic on neuronal adaptations in this have not been systematically examined and data available mostly from males. Here, we investigated changes total density relative concentration D2r-expressing neurons medial prefrontal cortex (mPFC), dorsal striatum (Dstr), nucleus accumbens (NAc), ventral tegmental area (VTA) both male female...
Cathepsin H (CatH) is a lysosomal cysteine protease with unique aminopeptidase activity. Its expression level increased in activated immune cells including dendritic cells, macrophages, and microglia. We have previously reported that CatH deficiency impairs toll-like receptor 3 (TLR3)-mediated activation of interferon regulatory factor (IRF3), the subsequent secretion (IFN)-β from cells. Furthermore, there increasing evidence IFN-β secreted microglia/macrophages has neuroprotective effects....
Disturbance of the internal environment in spinal cord after injury (SCI) is an important cause massive death neurons area and one major problems that lead to difficult recovery motor function patients. Rehmannia glutinosa, a famous traditional Chinese medicine, commonly used neurodegenerative diseases, whereas iridoid glycoside extract catalpol (CAT), with antioxidant, antiapoptotic, neuroprotective pharmacological effects. However, anti-apoptosis mechanism CAT SCI remains unclear. In our...
The elderly are particularly vulnerable to brain dysfunction after fracture surgery, but the mechanism underlying cognitive decline due anesthesia/surgery is not well understood. In this study, we observed hippocampus-dependent impairment in aged mice undergoing anesthesia and tibial a common model of postoperative mice. We used Golgi staining neuroelectrophysiological techniques detect structurally functionally impaired synaptic plasticity hippocampal CA1 region Postoperative mice,...
The role of the inositol 1, 4, 5-trisphosphate receptor (IP3R) in hippocampal neuronal apoptosis and cognitive dysfunction induced by sevoflurane is currently unclear. Therefore, this study, we investigated IP3R endoplasmic reticulum (ER) stress aged rats isolated neurons using both vivo vitro experiments, including bioinformatics, functional enrichment analysis, gene set hematoxylin, eosin staining, TUNEL assay, flow cytometry, western blot analysis transmission electron microscopy....
Cognitive impairment is a major complication of cerebral ischemia-reperfusion (CIR) injury and has an important impact on the quality life patients. However, precise mechanisms underlying cognitive after CIR remain elusive. In current study, we investigated role interleukin 17 A (IL-17A) injury-induced in wild-type IL-17A knockout mice using RNA sequencing analysis, neurological assessments, Golgi-Cox staining, dendritic spine immunofluorescence assay, western blot analysis. identified 195...
This research aimed to explore the influence of TLR deletion on sevoflurane-induced postoperative cognitive dysfunction in neonatal mice. Herein, WT and TLR3 KO mice, each with 24, were randomly divided into control group, sevoflurane TLR3â/â+sevoflurane group. The hippocampal neurons WT, RIP3 mice C SEV TLR3â/â+SEV group RIP3â/â+SEV extracted for vitro experiments. results revealed degeneration necrosis nerve cells Microscopic findings indicated that showed shrinkage nuclear...