A5016313679- Genetic factors in colorectal cancer
- Inflammatory Bowel Disease
- Cancer-related molecular mechanisms research
- Autoimmune and Inflammatory Disorders
- Eosinophilic Esophagitis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Multiple and Secondary Primary Cancers
- Barrier Structure and Function Studies
- Colorectal and Anal Carcinomas
- Gut microbiota and health
- Cancer Treatment and Pharmacology
- Pharmacological Effects of Natural Compounds
- Drug-Induced Hepatotoxicity and Protection
- Advanced Glycation End Products research
- Platelet Disorders and Treatments
- MicroRNA in disease regulation
- Diabetes Treatment and Management
- Pharmacology and Obesity Treatment
- Neuropeptides and Animal Physiology
- Ferroptosis and cancer prognosis
- Galectins and Cancer Biology
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Drug Transport and Resistance Mechanisms
Nanjing General Hospital of Nanjing Military Command
2010-2024
Nanjing University
2010-2024
Southern Medical University
2019
Jinling Institute of Technology
2010-2016
UCLouvain Saint-Louis Brussels
2014
Nanjing Medical University
2014
Background/Aims: This animal study aimed to define the underlying cellular mechanisms of intestinal barrier dysfunction.Methods: Rats were fed 4% with dextran sodium sulfate (DSS) induce experimental colitis.We analyzed sugars in 24-hour urine output by high pressure liquid chromatography.The expression claudins, mannan-binding lectin (MBL), and MBL-associated serine proteases 2 (MASP-2) detected colonic mucosa immunohistochemistry; apoptotic cells epithelium terminal deoxynucleotidyl...
The study aimed to investigate the relationship between gastroduodenal disease and diversity of cagA 3' variable region amino acid polymorphisms in Glu-Pro-Ile-Tyr-Ala (EPIYA) segments CagA C-terminal Helicobacter pylori (H. pylori).Gastric mucosal specimens from 170 patients our center (Nanjing, Jiangsu Province, China) were collected genomic DNA H. strains was extracted directly biopsied specimens. Polymerase chain reaction (PCR) used amplify gene, its assessed by direct sequencing.A total...
Considering the increasing prevalence of obesity/overweight, its treatment or prevention with new interventions can greatly help health and reduce adverse effects in people. One these is investigating effect Survodutide as a dual agonist glucagon GLP-1 receptors, which seems to be able influence weight loss processes different ways. In this study, we investigated injectable on loss. order identify all randomized controlled trials that factores related obesity, systematic search was conducted...
BACKGROUND:Peutz-Jeghers syndrome (PJS) is an autosomal dominant genetic disease. It severely decreases patient quality of life and leads elevated cancer risk. Germline mutation LKB1 the leading cause familial PJS. MATERIAL AND METHODS:To characterize germline gene in Chinese sporadic PJS patients, 14 families, 5 250 healthy adults were collected genomic DNAs peripheral blood extracted. Mutation screenings performed using MLPA (multiplex ligation-dependent probe amplification), PCR, direct...
Cronkhite-Canada syndrome (CCS) is a rare multiple gastrointestinal polyposis. Up till now, many complications of CCS have been reported in the literature, but rib fracture not included.We report case 58-year-old man who was admitted to our hospital with 6-month history frequent diarrhea, intermittent hematochezia and weight loss 13 kg. On admission, physical examination revealed alopecia scalp, hyperpigmentation hands soles, dystrophy fingernails. Laboratory data hypocalcaemia...
Peutz-Jeghers syndrome (PJS) is an uncommon autosomal dominant inherited disease, characterized by the occurrence of gastrointestinal hamartomatous polyps and pigmentation lips, buccal mucosa, digits. Patients with PJS have a significant risk for developing tumors in multiple organs. Germline mutation LKB1 gene, which encodes serine/threonine kinase that acts as tumor suppressor, has been identified cause PJS. The current study included two Chinese probands their available family members,...
A 46-year-old female underwent surgery for cancer of the right breast mammary (T3N2M0) in Sep 2010. Following post surgery, adjuvant chemotherapy CAF regimens (cyclophosphamide+adriamycin+fluorouracil) was administered. Two years later, multiple pulmonary and skeletal metastatic lesions had been found by CT (computerized tomography) ECT (emission computed tomograph) imaging. She received treatment second-line GP (cisplatin + gemcitabine). In meantime, we administered Chinese traditional herb...
目的：评估Peutz-Jeghers综合征（Peutz-Jeghers syndrome,PJS）患者并发恶性肿瘤的风险,提出监测建议.方法：通过Pubmed检索PJS并发恶性肿瘤的群组研究文献,并摘录符合条件的20篇文献中的相关资料进行分析.结果：共纳入3302例PJS患者,其中573人（17.35%）并发619例恶性肿瘤,包括消化系肿瘤368例（60.23%）,非消化系肿瘤243例（39.77%）.并发的常见恶性肿瘤中,依次为结直肠癌、小肠癌、乳腺癌、胃食管癌、妇科癌、胰腺癌、肺癌,且国内外发病频率具有一致性;PJS患者恶性肿瘤高发年龄段为11-70岁,国内患者有较年轻化的趋势.PJS并发任意癌的相对风险为9.0-18,并发消化系肿瘤的相对风险为13-50.5,并发乳腺癌的相对风险为13.9-20.3,并发妇科癌的相对风险为20.3,各年龄段癌症累积风险明显增高.有无STK11/LKB1基因突变对PJS并发恶性肿瘤风险无明显影响（P〉0.05）.结论：PJS患者为恶性肿瘤的高风险人群,其并发消化系肿瘤及消化系外癌的风险明显增高,应加强随诊筛查恶性肿瘤.