Circular RNAs (circRNAs) are a subclass of noncoding RNAs, playing essential roles in tumorigenesis and aggressiveness. Recent studies have revealed the pivotal functions circ-CTNNB1 (a circular RNA derived from CTNNB1) cancer progression. However, little is known about role osteosarcoma (OS), highly malignant bone tumour children adolescents.Circ-CTNNB1 was analysed by qRT-PCR, results were confirmed Sanger sequencing. The interaction effects between binding motif protein 15 (RBM15) through...

A CO₂-imprinted adsorbent was synthesized by crosslinking the CO₂ pre-adsorbed amino-terminated hyperbranched polymer, which prepared through Michael addition reaction between amines and methyl acrylate (MA) at 0 °C, followed self-condensation of products 100 °C 140 °C.

In this study, the mechanical properties of a combined seal ring under different loads were numerically calculated using ANSYS. The effect working pressure and pre-compression ratio rubber O-ring on contact stress was studied. influence wear ring’s chamfer, thickness, width force analyzed. Studies have shown that it is particularly important to select compression suitable for conditions. Under same conditions ratio, upon increasing decreased due decreasing bandwidth between cylinder wall....

Celastrol is an active compound extracted from the root bark of Triptergium wilfordii Hook F., also known as ̔Thunder God Vine̓. It a well-known Chinese medicinal herb that was found to inhibit tumor cell growth and promote apoptosis in several lines. However, research into its effects on osteosarcoma still extremely limited. The present study undertaken determine effect celastrol viability cells furthermore, illuminate molecular mechanism celastrol-induced apoptosis....

This study aimed to explore the effect of long non-coding RNA (LncRNA) H19 on proliferation and invasion lung carcinoma cells A549, determine its molecular targets.A549 were with either LncRNA or shRNA, expression levels evaluated by quantitative real-time PCR (RT-PCR). We measured cell using CCK-8 assay, counting assays, colony formation assay in response shLncRNA H19-2. Cell migration assessed wound healing Transwell respectively. The mRNA protein E-cadherin, N-cadherin, vimentin...

It is generally acknowledged that short-segment pedicle screw instrumentation the preferred surgical method for thoracolumbar fractures. However, use of with or without intermediate screws at fracture level remains controversial. We retrospectively evaluated 44 patients (28 men, 16 women) unstable The were divided into 2 groups according to used. In group 1, 24 underwent surgery a posterior approach via (1 above and 1 below fractured level). 2, 20 received an additional vertebrae. Clinical...

Osteosarcoma (OS) is a primary malignant tumor of the bone, with tendency to metastasize early. Despite advances in treatment options, more than 30% patients develop distant metastases, and prognosis these metastases extremely poor. Celastrol has been demonstrated manifest multiple pharmacological activities, including induction apoptosis numerous types cancer cell lines. Our previous studies have also suggested that capable inducing human osteosarcoma cells via mitochondrial-dependent...

Abstract Ewing's sarcoma is a high-grade malignancy bone and soft tissue tumor that most commonly occurs in children adolescents. Although the overall prognosis of has improved, 5-year survival rate not improved significantly. The study aimed to determine risk factors independently associated with construct nomogram predict patient survival. Patients diagnosed were collected from Surveillance, Epidemiology, End Results program database between 2004 2015 further divided into training...

The patella is an unusual location for primary and metastatic bone tumors to develop. most frequently encountered osteolytic lesions at the include giant cell of (GCT), chondroblastoma aneurysmal cysts (ABC). However, presentation ABC originating secondary a GCT rare. present study describes such case in 46-year-old female. differential diagnosis condition was extensive. patient underwent curettage addition cement fill defect. Pathological analysis resected tissue demonstrated that lesion...

A carbon dioxide imprinted solid amine adsorbent (IPEIA-R) with polyethylenimine (PEI) as a skeleton was conveniently prepared by using glutaraldehyde to cross-link dioxide-preadsorbed PEI. As confirmed FTIR, FT-Raman, and 13 C NMR spectroscopy, CO2 preadsorbed on PEI could occupy the reactive sites of amino groups act template for imprinting in cross-linking process. The imino formed from reaction between be reduced NaBH4 form -adsorbable groups. adsorption results indicated that reduction...

Abstract In this paper, the effect of contact forces combined sealing ring by pre-compressibility O-ring seal and working pressure is studied. The influence structural parameters (width, thickness chamfer) friction on analyzed. results show that, in seal, it not that higher pre-compressibility, efficiency. Under certain conditions, chamfer increases, decreases; almost unchanged; force increases with increase width ring. condition a given medium 25 MPa compressibility 22.5%, optimal values...

Pseudomyogenic hemangioendothelioma is a rare soft tissue tumor usually found in young adults, predominantly males. Fibrous dysplasia common benign bone tumor, which accounts for 5~7 % of all the primary tumors. However, pseudomyogenic secondary to fibrous extremely rare. To best our knowledge, this first case dysplasia. This study describes 14-year-old female who suffered from left lower extremity. The patient underwent two operations successively due pathological fractures femur and tibia...

Osteosarcoma is a common primary malignant tumor of bone, and the poor prognosis low 5-year survival rate have not improved for three decades. The present study aimed to effect combination celastrol cisplatin on human osteosarcoma cell line U-2OS, investigate mechanism by which celastrol/cisplatin induces apoptosis cells. MTT Annexin V-FITC/PI assays were used evaluate effects combined growth apoptosis, respectively, in U-2OS Morphological changes accompanying inhibition observed using...

Although Beclin-1, a well‑known key regulator of autophagy, has been demonstrated to serve function in number disorders, including cancer, aging and degenerative diseases, its biological Ewing sarcoma (ES) remains unresolved. The objective the present study was determine vitro effect Beclin‑1 knockdown on growth malignant phenotype ES SK‑ES‑1 cells, which have increased endogenous expression compared with RD‑ES investigate underlying molecular mechanism. Cell proliferation, invasion...

Extra‑articular synovial osteochondromatosis is a rare disease. The present study describes the case of 46‑year‑old female who suffered from extra‑articular left proximal thigh with limited hip movement. patient underwent total tumor resection and recovered well. was 15x14x5 cm³ in size located muscle gap. After 3‑month follow‑up, patient's motion improved computed tomography scan demonstrated no evidence recurrence. However, long‑term efficacy this procedure requires continuous observation...

Osteosarcoma (OS) is an aggressive bone cancer that most commonly affects adolescents and children. Emerging studies have shown long noncoding RNA (lncRNA) performs essential roles in the occurrence development of many tumors. Prostate androgen-regulated transcript 1 (PART 1) has been reported as a tumor oncogene; despite this, mechanisms underlying its involvement OS are unclear.OS paired normal tissue samples were obtained, gene expressions detected by real time-quantitative polymerase...

Synovial osteochondromatosis is a rare condition in which multiple cartilaginous nodules proliferate within the synovial membranes of joints, tendon sheaths or bursae. In general, complete synovectomy an effective method to treat this disease. Commonly involved joints are knee, glenohumeral joint, elbow, hip and ankle, although any articulation may be affected. However, occurs rarely wrist, there have been lack reports occurrence literature. The current study presents case 33-year-old man,...

Hemangioma is a common disease; however, intramuscular hemangioma (IH) presenting with pathological fracture extremely rare. The present study reports case of 46-year-old male patient that suffered from IH the right thigh, femoral fracture. was initially diagnosed traumatic fracture, and routine open reduction internal fixation were performed at local hospital. However, 20 days subsequent to surgery, gradual swelling soreness around incision observed. eventually ruptured during squatting for...

An aneurysmal bone cyst (ABC) is a rare, non-neoplastic, destructive, hemorrhagic and expansile lesion accounting for 1% of all tumors. This type predominantly affects long bones vertebrae. ABC the metatarsal rare only few cases have been reported in literature to date. The present study reports case third occurring 27-year-old male patient, who presented with repeated foot swelling that had lasted ~1 year. Other clinical manifestations included limping, multiple lumps (defined as masses on...

Abstract Rationale: Chordoma is a relatively rare tumor that accounts for 1% to 4% of all malignant bone tumors, with an annual incidence <0.1 per 100,000 people. Although chordoma aligned the axis spine and most commonly develops in sacrum, best our knowledge, giant sacrococcygeal extremely rare. Patient concerns: A 61-year-old Chinese man presented massive dorsal sacral mass. The patient's primary complaint was that, during last two months, mass had been increasing size his right lower...

Abstract Background In a previous study, we have identified that circ-CTNNB1 (a circular RNA derived from CTNNB1) drives cancer progression through the activation of Wnt/β-catenin signaling pathway in various tumors. However, functions regulating osteosarcoma (OS, highly malignant bone tumor children and adolescents) remain unclear. this aimed to assess role OS identify underlying mechanisms, which may contribute exploration potential therapeutic strategy for OS. Methods Circ-CTNNB1 was...