A5101718230- Immune cells in cancer
- Lung Cancer Research Studies
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Toxic Organic Pollutants Impact
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Immune Response and Inflammation
- Orthopedic Infections and Treatments
- Cancer-related gene regulation
- Orthopaedic implants and arthroplasty
- Bone and Joint Diseases
- Effects and risks of endocrine disrupting chemicals
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
- Heat shock proteins research
- Chronic Kidney Disease and Diabetes
- Inflammatory mediators and NSAID effects
Nanjing General Hospital of Nanjing Military Command
2021-2025
Zhongshan Hospital of Xiamen University
2019-2025
Nanjing Medical University
2025
Nanjing University
2021-2025
University of Science and Technology of China
2024
Fujian Medical University
2017-2024
Shandong University
2023
First Affiliated Hospital of Henan University
2023
Second Hospital of Anhui Medical University
2022
Anhui Medical University
2022
Patient-derived tumor xenograft models have been established and increasingly used for preclinical studies of targeted therapies in recent years. However, patient-derived non-small cell lung cancer (NSCLC) mouse are relatively few number limited their degree genetic characterization validation. In this study, we aimed to establish a variety NSCLC characterize these common aberrations provide more informative drug efficacy testing.NSCLC tissues from thirty-one patients were collected...
Abstract Background and Aims Lenvatinib is a first‐line drug commonly used in the treatment of advanced hepatocellular carcinoma (HCC). However, its clinical efficacy very limited due to resistance. Therefore, there great need explore combination with other agents achieve better therapeutic effects. Metformin has been demonstrated show an anti‐cancer effect. This study aimed investigate combined effect lenvatinib metformin HCC cells both vitro vivo elucidate possible molecular mechanisms....
We report a case of primary cutaneous zygomycosis caused by Rhizomucor variabilis and review 6 cases reported from China that share similar features are different those other species Mucorales. It is noteworthy all the were observed in 3 adjacent provinces eastern China.
Background: Hepatocellular carcinoma (HCC) is one of the most frequent cancers and third leading cause cancer-related deaths. It has been reported that lysosomal associated transmembrane protein LAPTM4B expression significantly upregulated in human closely with tumor initiation progression. Purpose: We aimed to reveal relevance pathogenesis HCC. Methods: Cell viability assessment, colony formation assay, vivo xenograrft model, microarray, real-time PCR, immunofluorescence western blot...
Although hyperhomocysteinemia (hHcys) has been recognized as an important independent risk factor in the progression of end-stage renal disease and development cardiovascular complications related to disease, mechanisms triggering pathogenic actions hHcys are not fully understood. The present study was mainly designed investigate role HDACs injury induced by hHcys. Firstly, we identified expression patterns found that, among zinc-dependent HDACs, HDAC9 preferentially upregulated kidney from...
Interleukin 17 (IL-17) has been found to be increased in some human cancers; however, the possible implication of IL-17 regulating antitumor responses lung cancer patients with malignant pleural effusions (MPE) remains elucidated. This study aimed investigate diagnostic value and carcinoembryonic antigen (CEA) MPE benign (BPE). Pleural effusion samples from 108 were classified on basis diagnosis as (n = 56) BPE 52). The concentration was determined by enzyme-linked immunosorbent assay...
The aim of the present study was to examine expression integrin β1 in squamous cell carcinoma (SCC) cervix and its association with clinicopathological features patients. 87 SCC cervical tissues 32 normal detected using an enzyme‑linked immunosorbent assay, western blot analysis immunohistochemical streptavidin‑peroxidase method. Integrin greater compared that (P<0.05), mean level also markedly higher (P<0.05). In terms between features, patients stage IIA had positive rates I histological...
Abstract Background A recent study reported the role of long non-coding RNA (lncRNA) RBAT1 in promoting development retinoblastoma and bladder cancer. However, its function other cancers is unclear. We then studied endometrial carcinoma (EC). Methods The expression miR-27b EC paired non-tumor samples from advanced patients, as well plasma patients healthy controls were detected by RT-qPCR. direct interaction between miR-27b, subcellular location determined RNA-RNA pulldown assay...
HSPA13, an important member of the heat shock protein family, plays essential role in oncogenesis many organs, but mechanism and function hepatocellular carcinoma (HCC) is still unclear. In present study, we found that HSPA13 was highly expressed HCC predicted poor clinical prognosis. Upregulation significantly associated with vascular invasion patients. Functionally, knockdown experiments demonstrated promoted proliferation, migration, invasion. Mechanistic investigation showed could...
Although Beclin-1, a well‑known key regulator of autophagy, has been demonstrated to serve function in number disorders, including cancer, aging and degenerative diseases, its biological Ewing sarcoma (ES) remains unresolved. The objective the present study was determine vitro effect Beclin‑1 knockdown on growth malignant phenotype ES SK‑ES‑1 cells, which have increased endogenous expression compared with RD‑ES investigate underlying molecular mechanism. Cell proliferation, invasion...
For thymic carcinoma (TC), which is a rare epithelial neoplasm of the thymus gland, median survival with current treatments only 2 years.Mutations in epidermal growth factor receptor (EGFR) gene or its downstream effectors may cause constitutive activation that leads to cell proliferation and metastases. Thus, molecular profiling essential for selecting TC patients who respond anti-EGFR therapies.Genomic DNA was extracted from 61 histological samples TCs. Real-time polymerase chain reaction...
The molecular mechanisms underlying proliferation and apoptosis induced by pentabrominated diphenyl ethers (5-BDE) through regulation of mRNA protein expression Bcl-2 Bax was investigated using breast cancer MCF-7 cells. Human cells were grown in DMEM medium, MTT assay employed to investigate cell proliferation. RT-PCR immunohistochemistry performed determine Bax. Within the range 1 × 10−8–10−4mol L−1, polybrominated (PBDE) stimulated a concentration- time-dependent manner. analyses revealed...
Abstract Background A subset of neutrophils isolated from peripheral blood mononuclear cells (PBMC) has recently been described in cancer patients. Methods Double gradient centrifugation was used to separate neutrophil subset. Western blot assay performed assess CCDC25 expression level. Results In this study, we found that low density neutrophils(LDNs) were highly enriched metastatic hepatocellular carcinoma (HCC) patients compared non-metastatic HCC Then, showed the most prominent marker on...