A5024659860- Neuroblastoma Research and Treatments
- Adipose Tissue and Metabolism
- Cell death mechanisms and regulation
- Acute Myeloid Leukemia Research
- Protein Degradation and Inhibitors
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- Phagocytosis and Immune Regulation
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Genomics and Chromatin Dynamics
- Cancer-related Molecular Pathways
- Circadian rhythm and melatonin
- Hepatitis B Virus Studies
- Neuroendocrine Tumor Research Advances
- Retinoids in leukemia and cellular processes
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Berberine and alkaloids research
- Tryptophan and brain disorders
- NF-κB Signaling Pathways
- Cell Adhesion Molecules Research
Binzhou University
2025
Binzhou Medical University
2025
Shandong University
2014-2024
Jilin Agricultural University
2024
Kunming Medical University
2024
University of Electronic Science and Technology of China
2021-2023
Sichuan Academy of Traditional Chinese Medicine
2023
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2018-2023
Saint Louis University
2014-2021
Guangzhou University of Chinese Medicine
2021
Adipose-derived stem cells (ADSCs) play critical roles in controlling obesity-associated inflammation and metabolic disorders. Exosomes from ADSCs exert protective effects several diseases, but their obesity related pathological conditions remain unclear. In this study, we showed that treatment of obese mice with ADSC-derived exosomes facilitated homeostasis, including improved insulin sensitivity (27.8% improvement), reduced obesity, alleviated hepatic steatosis. drove alternatively...
Circadian dysfunction is a common attribute of many neurodegenerative diseases, most which are associated with neuroinflammation. rhythm has been inflammation in the periphery, but role core clock neuroinflammation remains poorly understood. Here we demonstrate that Rev-erbα, nuclear receptor and circadian component, mediator microglial activation We observed time-of-day oscillation immunoreactivity hippocampus, was disrupted Rev-erbα −/− mice. deletion caused spontaneous hippocampus...
Regulation of glial activation and neuroinflammation are critical factors in the pathogenesis Alzheimer's disease (AD). YKL-40, a primarily astrocytic protein encoded by gene Chi3l1, is widely studied cerebrospinal fluid biomarker that increases with aging early AD. However, function Chi3l1/YKL-40 AD unknown. In cohort patients AD, we observed variant human CHI3L1 gene, which results decreased CSF YKL-40 expression, was associated slower progression. At baseline, Chi3l1 deletion mice had no...
Despite the declining trend, stomach cancer remains second most common worldwide. We examined role of green tea consumption on chronic gastritis and risks. A population-based case-control study was conducted in Yangzhong, China, with 133 cases, 166 433 healthy controls. Epidemiologic data were collected by standard questionnaire odds ratios (OR) 95% confidence intervals (CI) estimated using logistic regression models SAS. Inverse association observed between drinking After adjusting for age,...
Treating neuropathic pain is challenging and novel non-opioid-based medicines are needed. Using unbiased receptomics, transcriptomic analyses, immunofluorescence, in situ hybridization, we found that the expression of orphan GPCR Gpr160 GPR160 increased rodent dorsal horn spinal cord following traumatic nerve injury. Genetic immunopharmacological approaches demonstrated inhibition prevented reversed male female rodents without altering normal response. attenuated sensory processing thalamus,...
Abstract While apoptotic cell death is known to be central the pathogenesis of radiation-induced liver injury (RILI), mechanistic basis for this activity remains poorly understood. N 6 -methyladenosine (m A) modifications are most common form reversible methylation observed on lncRNAs in eukaryotic cells, with their presence leading pronounced changes a range biological processes. The degree which m A modification plays role induction response ionizing radiation (IR) context RILI...
PURPOSE: To determine the independent prognostic significance of 1p36 loss heterozygosity (LOH) in a representative group neuroblastoma patients. PATIENTS AND METHODS: Diagnostic tumor specimens from 238 patients registered onto most recent Children’s Cancer Group phase III clinical trials were assayed for LOH with 13 microsatellite polymorphic markers spanning chromosome band 1p36. Allelic status at was correlated other variables and disease outcome. RESULTS: detected 83 (35%)...
Abstract Background Tumor invasion and metastasis are the major reasons for leading death of patients with hepatocellular carcinoma (HCC). Therefore, to identify molecules that can suppress tumor will provide novel targets HCC therapies. necrosis factor (TNF)-alpha-induced protein 8-like 2, TIPE2, is a immune negative molecule an inhibitor oncogenic Ras in mice but its function human unclear. Our previous research has shown TIPE2 downregulated primary compared paired adjacent non-tumor...
Adipose-derived stem cells (ADSCs) have been used to control several autoimmune or inflammatory diseases due immunosuppressive properties, but their role in obesity-associated inflammation remains unestablished. This study aims evaluate the effects of ADSCs on obesity-induced white adipose tissue (WAT) and insulin resistance. We found that diet-induced obesity caused a remarkable reduction ADSC fraction mouse WAT. Delivery lean mouse-derived ADSCs, which could successfully locate into WAT...
The circadian clock regulates various aspects of brain health including microglial and astrocyte activation. Here, we report that deletion the master protein BMAL1 in mice robustly increases expression complement genes, C4b C3, hippocampus. transcriptional repressor REV-ERBα, REV-ERBα causes increased transcript neurons astrocytes as well C3 primarily astrocytes. phagocytosis synapses synapse loss CA3 region Finally, observed diurnal variation degree synaptic which was antiphase to...
Adipose-derived stem cells (ASCs) drive healthy visceral adipose tissue (VAT) expansion via adipocyte hyperplasia. Obesity induces ASC senescence that causes VAT dysfunction and metabolic disorders. It is challenging to restrain this process by biological intervention, as mechanisms of controlling remain unclear. We demonstrate a population CX3CR1hi macrophages maintained in mouse during short-term energy surplus, which sustains ASCs restraining their senescence, driving adaptive health....
Serum response factor (SRF) is a ubiquitously expressed transcription that regulates cell-specific functions such as muscle development and breast cancer metastasis. The myocardin-related factors (MRTFs), which are transcriptional coactivators mediating of SRF, also expressed. How MRTFs SRF drive still not fully understood. Here we show LIM domain only 7 (LMO7) regulator plays an important role in cell migration. LMO7 activates by relieving actin-mediated inhibition manner requires,...
Abstract Macrophage foam cells, a major component of the atherosclerotic lesion, have vital roles in development atherosclerosis. Lipoautophagy, type autophagy characterized by selective delivery lipid droplet for lysosomal degradation, may impact atherosclerosis regulating macrophage cell formation. Previously, we reported that programmed death 4 (PDCD4), tumor suppressor, negatively regulated cells. However, its lipoautophagy, formation and remain to be established. Here found Pdcd4...
A growing body of evidence demonstrates that autophagy, an evolutionarily conserved intracellular degradation process, is involved in the pathogenesis atherosclerosis and has become a potential therapeutic target. Here we tested effect two inhibitors phosphatidylinositol 3-kinase, 3-methyladenine (3-MA) 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), commonly used as apolipoprotein E-/- mice. Systemic application 3-MA but not LY294002 markedly reduced size atherosclerotic plaque increased...
Abstract Brain-derived neurotrophic factor (BDNF) is a growth that plays vital roles in the neuron survival, growth, and neuroplasticity. Alteration to BDNF expression associated with major depressive disorder. However, translational machinery depression remains unknown. Herein, we pointed Pdcd4, suppressor oncogene, acted as an endogenous inhibitor for translation of BDNF, selectively repressed splice variant IIc mRNA eIF4A-dependent manner. Chronic restraint stress (CRS) up-regulated Pdcd4...
Abstract The appropriate transcriptional activity of PPARγ is indispensable for controlling inflammation, tumor and obesity. Therefore, the identification key switch that couples activation with degradation to sustain its homeostasis extremely important. Unexpectedly, we here show acetyl-CoA synthetase short-chain family member 2 (ACSS2) critically controls via SIRT1 enhance adipose plasticity promoting white tissues beiging brown thermogenesis. Mechanistically, ACSS2 binds directly...