A5077165179- Developmental Biology and Gene Regulation
- Hedgehog Signaling Pathway Studies
- Genetic and Kidney Cyst Diseases
- Epigenetics and DNA Methylation
- Wnt/β-catenin signaling in development and cancer
- Hippo pathway signaling and YAP/TAZ
- Invertebrate Immune Response Mechanisms
- Pluripotent Stem Cells Research
- RNA Research and Splicing
- Cellular Mechanics and Interactions
- Microtubule and mitosis dynamics
- Animal Genetics and Reproduction
- Renal and related cancers
- Congenital heart defects research
- Insect symbiosis and bacterial influences
- Genetic Syndromes and Imprinting
- Genomics and Chromatin Dynamics
- Protist diversity and phylogeny
- Cancer Cells and Metastasis
- TGF-β signaling in diseases
- Silk-based biomaterials and applications
- Genetics and Neurodevelopmental Disorders
- Cancer-related gene regulation
- Antimicrobial Peptides and Activities
- Neurogenesis and neuroplasticity mechanisms
Memorial Sloan Kettering Cancer Center
2009-2023
Brown University
2023
Northwest University
2023
Kettering University
2009-2020
Cornell University
1998-2020
Charles Sturt University
2018
Our Lady of the Lake University
2014
Developmental Studies Center
2009
Graduate School USA
2008
Hôpital Xavier Arnozan
2008
The intraflagellar transport (IFT) proteins Ift172/Wimple and Polaris/Ift88 the anterograde IFT motor kinesin-II are required for production maintenance of cilia. These also activation targets mouse Hedgehog (Hh) pathway by Gli transcription factors. phenotypes mutants, however, not identical to mutants that lack Smoothened (Smo), an essential activator Hh pathway. We show here embryos both Ift172 Smo single which indicates acts downstream Smo. have a weaker neural patterning phenotype than...
Components of microbial cell walls are potent activators innate immune responses in animals. For example, the mammalian TLR4 signaling pathway is activated by bacterial lipopolysaccharide and required for resistance to infection Gram-negative bacteria. Other components surfaces, such as peptidoglycan, also responses, but less known about how those activate host defense. Here we show that a peptidoglycan recognition protein, PGRP-LC, absolutely induction antibacterial peptide genes response...
Low-density lipoprotein receptor-related protein 4 (Lrp4) is a member of family structurally related, single-pass transmembrane proteins that carry out variety functions in development and physiology, including signal transduction receptor-mediated endocytosis. Lrp4 expressed multiple tissues the mouse, important for proper morphogenesis limbs, ectodermal organs, lungs kidneys. We show also post-synaptic endplate region muscles required to form neuromuscular synapses. Lrp4-mutant mice die at...
Mammalian Sonic hedgehog (Shh) signaling is essential for embryonic development and stem cell maintenance has critical roles in tumorigenesis. Although core components of the Shh pathway are conserved evolution, important aspects mammalian not shared with Drosophila pathway. Perhaps most dramatic difference between pathways that mouse requires a microtubule-based organelle, primary cilium. Proteins required response to enriched cilium, but it clear why cilium provides an appropriate venue...
PIK3CA mutations induce venous malformations.