A5000052827- Congenital heart defects research
- Epigenetics and DNA Methylation
- Developmental Biology and Gene Regulation
- Folate and B Vitamins Research
- Congenital Heart Disease Studies
- Receptor Mechanisms and Signaling
- Protein Kinase Regulation and GTPase Signaling
- Tracheal and airway disorders
- Ubiquitin and proteasome pathways
- Iron Metabolism and Disorders
- Prenatal Screening and Diagnostics
- Adenosine and Purinergic Signaling
- Congenital Diaphragmatic Hernia Studies
- Pregnancy and preeclampsia studies
- Kruppel-like factors research
- Renal and related cancers
- Heat shock proteins research
- Melanoma and MAPK Pathways
- Wnt/β-catenin signaling in development and cancer
- Neurogenesis and neuroplasticity mechanisms
- Genetic and Kidney Cyst Diseases
- Hedgehog Signaling Pathway Studies
- Trace Elements in Health
- PI3K/AKT/mTOR signaling in cancer
- Connective tissue disorders research
Children's National
2015-2025
National Hospital
2024
George Washington University
2013-2020
John Wiley & Sons (United States)
2017
University of North Carolina at Chapel Hill
1994-2010
UNC Lineberger Comprehensive Cancer Center
1998-2010
Howard Hughes Medical Institute
2003-2010
University of Colorado Denver
2005-2010
Kettering University
2005
Memorial Sloan Kettering Cancer Center
2003
In GN4 rat liver epithelial cells, angiotensin II (Ang II) and other agonists which activate phospholipase C stimulate tyrosine kinase activity in a calcium-dependent, protein (PKC)-independent manner.Since Ang also produces proliferative response these we investigated downstream signaling elements traditionally linked to growth control by kinases.First, II, like epidermal factor (EGF), stimulated AP-1 binding PKC-independent manner.Because increases can reflect induction of c-Jun c-Fos,...
1. Stimulation of P2Y-purinoceptors on turkey erythrocytes and many other cell types results in activation phospholipase C. In contrast, we have observed recently that C6 rat glioma cells are not coupled to C, but rather, inhibit adenylyl cyclase. 2. this study investigated the pharmacological selectivity P2-purinoceptor antagonists, suramin, reactive blue 2, pyridoxal phosphate 6-azophenyl 2',4'-disulphonic acid (PPADS) for C- cyclase-coupled P2Y-purinoceptors. 3. cells, suramin 2...
Hectd1 mutant mouse embryos exhibit the neural tube defect exencephaly associated with abnormal cranial mesenchyme. Cellular rearrangements in mesenchyme are essential during neurulation for elevation of folds. Here we investigate molecular basis behavior We demonstrate that is a functional ubiquitin ligase and one its substrates Hsp90, chaperone protein both intra- extracellular clients. Extracellular Hsp90 enhances migration multiple cell types. In cells, secretion emigration cells from...
The Mas oncogene encodes a novel G-protein-coupled receptor that was identified originally as transforming protein when overexpressed in NIH 3T3 cells. mechanism and signaling pathways mediate transformation have not been determined. We observed the foci of transformed cells caused by were similar to those activated Rho Rac proteins. Therefore, we determined if are mediated through activation specific family protein. First, that, like Rac1, cooperated with Raf synergistic Second, both Mas-...
Summary We assessed feeding-related developmental anomalies in the LgDel mouse model of Chromosome 22q11 Deletion Syndrome (22q11DS), a common disorder that frequently includes perinatal dysphagia - debilitating feeding, swallowing and nutrition difficulties from birth onward within its phenotypic spectrum. pups gain significantly less weight during first postnatal weeks, have several signs respiratory infections due to food aspiration. Most genes are expressed anlagen craniofacial brainstem...
Neural tube defects (NTDs) are some of the most common birth observed in humans. The incidence NTDs can be reduced by peri-conceptional folic acid supplementation alone and even further with plus a multivitamin. Here, we present evidence that iron maybe an important nutrient necessary for normal development neural tube. Following implantation mouse embryo, ferroportin 1 (Fpn1) is essential transport from mother to fetus expressed visceral endoderm, yolk sac placenta. flatiron (ffe) mutant...
Disrupted development of oropharyngeal structures as well cranial nerve and brainstem circuits may lead to feeding swallowing difficulties in children with 22q11.2 deletion syndrome (22q11DS). We previously demonstrated aspiration-based dysphagia during early postnatal life the LgDel mouse model 22q11DS along disrupted morphogenesis divergent differentiation function motor sensory nerves. now ask whether deficits persist adult mice using methods analogous those used human patients evaluate...