A5100779364- Microtubule and mitosis dynamics
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Advanced Thermodynamics and Statistical Mechanics
- Thermal Radiation and Cooling Technologies
- Optical properties and cooling technologies in crystalline materials
- Urticaria and Related Conditions
- Mechanisms of cancer metastasis
- Hippo pathway signaling and YAP/TAZ
- Anorectal Disease Treatments and Outcomes
- Extracellular vesicles in disease
- Bladder and Urothelial Cancer Treatments
- Quantum Electrodynamics and Casimir Effect
- Renal Diseases and Glomerulopathies
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Sirtuins and Resveratrol in Medicine
- Surgical site infection prevention
- Cancer-related Molecular Pathways
- Plant Micronutrient Interactions and Effects
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Trace Elements in Health
- Vasculitis and related conditions
Second Hospital of Shanxi Medical University
2025
Shanxi Medical University
2025
Nanchang University
2005-2023
First Affiliated Hospital of Nanchang University
2019-2023
China Medical University
2022
Guangdong Medical College
2021
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2021
Huazhong Agricultural University
2016
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2013
The Ohio State University
2013
Our previous study indicates that Silent information regulator 1 (Sirt1) is involved in macroautophagy by upregulating light chain 3 (LC3) expression astrocyte to exert a neuroprotective effect. Chaperon-mediated autophagy (CMA), another form of autophagy, also upregulated after brain injury. However, little known about the role Sirt1 regulation CMA. In present study, an vivo model closed head injury (CHI) and vitro primary cortical stimulated with interleukin-1β were employed mimic...
The transcript factor LHX2 is dysregulated in many cancers but its role osteosarcoma (OS) remains unclear.In this study, we confirm that up-regulated osteosarcoma, and silencing inhibits OS malignancy induces autophagy via mTOR signaling.We further demonstrate miR-129-5p negatively regulates suppresses the malignant phenotypes of OS.LHX2 overexpression could restore phenotypes.In conclusion, tumorigenesis regulated by miR-129-5p.Targeting miR-129-5p/LHX2/mTOR axis therefore represents a...
Boron is an essential trace element which plays important role in process of metabolism and the function tissues.However, effects boron on intestinal cells African ostrich chicks are poorly reported.Therefore, this study was designed to investigate proliferation apoptosis cells.A total 36, ten day-old were randomly divided into six groups fed same basal diet supplemented with 0, 40, 80, 160, 320 640 mg/L boric acid drinking water for 80 days.Proliferating cell nuclear antigen (PCNA) used...
Abstract Background Autophagy plays an essential role in metastasis of malignancies. Although our studies showed that Aurora-B facilitate pulmonary OS, the mechanism kinase on autophagy and OS has not been explored. Methods Clinical-pathological parameters follow-up information was collected patients. Immunohistochemical staining performed to detect LC3 protein tissues. Short hairpin RNA transfection used silence cells. Real-time quantitative PCR (RT-qPCR) mRNA expression related were...
Transforming growth factor (TGF)-β signaling is strongly related to the development and progression of tumor. We aimed construct a prognostic gene signature based on TGF-β signaling-related genes for predicting clinical prognosis immunotherapy responses patients with clear cell renal carcinoma (ccRCC).The expression profiles corresponding information ccRCC were collected from TCGA ArrayExpress (E-MTAB-1980) databases. LASSO, univariate multivariate Cox regression analyses conducted in...
Osteosarcoma (OS) is the most common primary malignant tumor of bone in young adolescents and children. We explored underlying mechanism Aurora-B promoting OS cell proliferation metastasis. Bioinformatics was employed to predict substrate Aurora-B. IHC Western blot were used confirm correlation between NPM1. ERK/NF-κβ pathway-related proteins detected by immunofluorescence (IF). CCK8, wound healing, transwell, Tunel assays identify proliferation, migration apoptosis potential. Spontaneous...
Our previous studies have isolated cytochalasin H (CyH) from endophytic fungus derived mangrove and found that CyH induced apoptosis inhibited migration angiogenesis in non-small cell lung cancer (NSCLC) cells.In this study, we further investigated the effect of on epithelial-mesenchymal transition (EMT) stemness A549 NCI-H460 NSCLC cells underlying mechanisms, especially role YAP/ TAZ signaling pathway process.Our results showed significantly invasive ability sphere formation cells.The...
To investigate the effect of Aurora kinase B (AURKB) silencing-induced autophagy on apoptosis osteosarcoma 143B cells and underlying molecular mechanisms.Human were transfected with Lv/shAURKB or negative control vector Lv/shScrambled followed by treatment chloroquine (CQ) for 24 h. Western blotting was performed to detect protein expression levels AURKB, P62, LC3, cleaved caspase-3, Bcl-2, P-ULK1Ser555. Transmission electron microscopy LC3 dual-label fluorescence method used trace...
A new model of a quantum refrigeration cycle composed two adiabatic and isomagnetic field processes is established. The working substance in the consists many non-interacting spin-1/2 systems. performance investigated, based on master equation semi-group approach. general expressions several important parameters, such as coefficient performance, cooling rate power input, are given. It found that this closest analogy to classical Carnot cycle. Furthermore, at high temperatures optimal...
<title>Abstract</title> <bold>Background. </bold>The aim of this study is to investigate the clinicopathologic characteristics, treatment and prognosis crescentic glomerulonephritis (Crescentic GN) in patients with normal renal function at diagnosis, compare those impaired function. <bold>Methods. </bold>We conducted a retrospective review biopsy proven Crescentic GN our center divided them into eGFR group (eGFR≥60 ml/min/1.73 m<sup>2</sup>) low (eGFR <60 m<sup>2</sup>). Clinical...
Abstract Background Autophagy plays an essential role in metastasis of malignancies. Although our studies showed that Aurora-B facilitate pulmonary OS, the mechanism kinase on autophagy and OS has not been explored. Methods Clinical-pathological parameters follow-up information was collected patients. Immunohistochemical staining performed to detect LC3 protein tissues. Short hairpin RNA transfection used silence cells. Real-time quantitative PCR (RT-qPCR) mRNA expression related were...
Abstract Mung beans are traditional medicine and food homologous crops in China, widely planted welcomed by consumers. In this work, we compared the nutrient compositions (including moisture, ash, protein, dietary fiber, amino acids fatty acids) of 7 kinds mung beans, qualitative quantitative identified phenolic compounds their methanol extracts UPLC-ESI-QTOF-MS HPLC-ESI-QQQ-MS/MS, as well antioxidant properties. The protein (20–25%) was main nutritional component contents varied from 1.1 to...
Abstract Background: Autophagy plays an essential role in metastasis of malignancies. Although our studies showed that Aurora-B facilitate pulmonary OS, the mechanism kinase on autophagy and OS has not been explored. Methods: Clinical-pathological parameters follow-up information was collected patients. Immunohistochemical staining performed to detect LC3 protein tissues. Short hairpin RNA transfection used silence cells. Real-time quantitative PCR (RT-qPCR) mRNA expression related were...