Abstract Introduction This study tested the self‐reported sleep characteristics associated with cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers in cognitively intact older adults. Methods The linear and non‐linear regression analyses were conducted 736 normal participants (mean [standard deviation; SD] age, 62.3 [10.5] years, range 40 to 88 59% female) who had measurements of amyloid beta (Aβ) tTau proteins characteristics, after adjusting for gender, education, apolipoprotein...

Abstract Background Loss of function triggering receptor expressed on myeloid cell 2 (TREM2), a key selectively by microglia in the brain, contributes to development Alzheimer’s disease (AD). Whether TREM2 levels are pathologically altered during preclinical phase, and whether cerebrospinal fluid (CSF) soluble protein (sTREM2) has relationship with major pathological processes including Aβ tau deposition still unclear. Methods According NIA-AA criteria, 659 cognitively normal participants...

Abstract Introduction This study delineated the interrelationships among blood pressure (BP), cerebrospinal fluid (CSF) core biomarkers of Alzheimer's disease (AD), and cognition. Methods The linear regression analyses were conducted in 1546 non‐demented participants (mean age 61.58 years, range 40 to 89 years; 40% female; average days BP measurement, 9.10 days). Mediation with 10,000 bootstrapped iterations used explore mediation effects. Results A clear age‐related pattern was delineated....

Increasing evidences supported that subjective cognitive decline (SCD) might be a potential first symptomatic manifestation of Alzheimer's disease (AD). The rapidly growing number SCD individuals who seek medical help and advice also makes it urgent to develop more precise strategy for SCD. Therefore, this study aimed explore the risk factors Logistics linear regression models were performed investigate 41 in 1165 participants without objective impairment. Cochran-Armitage trend test was...

Abstract Purpose We aimed to investigate the relevance of body mass index (BMI) postoperative delirium (POD), and test whether influences BMI on POD were mediated by cerebrospinal fluid (CSF) biomarkers. Patients methods Our study recruited 682 761 cognitively intact individuals from perioperative neurocognitive disorder risk factor prognosis (PNDRFAP) biomarker lifestyle (PNDABLE) study, respectively. The incidence was evaluated using Confusion Assessment Method (CAM), severity measured...

Abstract Background Postoperative delirium (POD) is a frequent complication after surgery and its occurrence associated with poor outcomes. The neuropathology of this unclear, but it important to evaluate relevant biomarkers for postoperative status. purpose study explore the relationship between expression levels cholinergic in cerebrospinal fluid (CSF) development POD elderly patients. Methods Four hundred ninety-two patients aged 65 years old or older elective total hip/knee replacement...

Objectives The amyloid/tau/neurodegeneration (AT[N]) framework has conceptualized the Alzheimer's disease (AD) continuum as a of with evidence amyloid‐related pathologies independent clinical manifestation. Based on this framework, it is necessary to reveal distribution and risk factors AD in cognitively intact population among different cohorts races, including northern Chinese Han population. Methods This study classified Biomarker LifestylE (CABLE) participants through AT(N) scheme....

Abstract Objectives This study aimed to reveal the relationship between alcohol consumption and Postoperative delirium (POD) in elderly. Methods We selected 252 patients from Perioperative Neurocognitive Disorder And Biomarker Lifestyle (PNDABLE ) study. Patients PNDABLE database have been measured for Alzheimer-related biomarkers CSF (Aβ 40 , Aβ 42 P-tau, tau protein). Mini-Mental State Examination (MMSE) was used assess preoperative mental status of patients. POD diagnosed using Confusion...

Abstract Objective Our study aimed to investigate the correlation between intraoperative hypothermia and postoperative delirium (POD) in patients undergoing general anesthesia for gastrointestinal surgery. Methods The comprised 750 participants from Perioperative Neurocognitive Disorder Risk Factor Prognosis (PNDRFAP) database, which ultimately screened 510 individuals final analysis. Preoperative cognitive function was evaluated using Mini‐Mental State Examination (MMSE). occurrence of POD...

We aimed to investigate the relationship between preoperative lipid level and postoperative delirium (POD) explore whether lipid's effect on POD is mediated by core protein. A total of 635 patients who were planned undergo knee/hip arthroplasty under combined spinal-epidural anesthesia, regardless gender, selected. The aged 40-90 years with American Society Anesthesiologists physical status I II. Mini-Mental State Examination (MMSE) was completed 1 day before operation. Five milliliter elbow...

Abstract Introduction This study sought to explore the association between Life’s Simple 7 (LS7) and cerebrospinal fluid (CSF) Alzheimer’s disease (AD) pathological biomarkers in cognitively normal northern Chinese population. Methods From Biomarker LifestylE (CABLE) study, 1106 participants were enrolled. The mean age was 62.34 years, 39.6% female. LS7 scores summed with each metric assigned 0, 1, or 2 scores. multiple linear regression models used investigate CSF AD biomarkers. Results We...

Abstract Objectives In this study, the relationship between preoperative neutrophil‐to‐lymphocyte ratio (NLR) and Alzheimer‐related biomarkers in cerebrospinal fluid (CSF) was investigated to determine whether high NLR is a potential risk factor for postoperative delirium (POD) evaluate its predictive efficacy. Methods We selected 1000 patients from perioperative neurocognitive disorder prognosis (PNDRFAP) database 999 biomarker lifestyle (PNDABLE) database. Patients PNDABLE have been...

This study delineated the interrelationships between subclinical alterations in left heart, cerebrospinal fluid (CSF), Alzheimer's disease (AD) biomarkers, and cognition.

Background: Green tea has been widely recognized in ameliorating cognitive impairment and Alzheimer’s disease (AD), especially the progression of dysfunction. But underlying mechanism is still unclear. Objective: This study was designed to determine role green consumption association with cerebrospinal fluid (CSF) biomarkers AD pathology ascertain whether specific population backgrounds showed differences toward these relationships. Methods: Multivariate linear models analyzed available data...

Abstract Background In the global aging population, incidence of postoperative delirium (POD) is increasing. Therefore, finding its effective predictive tools becomes crucial. We aimed to identify potential Cerebrospinal fluid (CSF)biomarkers for POD. Methods A total 825 patients undergoing knee/hip arthroplasty under combined spinal-epidural anesthesia were selected. The aged 40 90 years with American Society Anesthesiologists physical status I~II. Mini-Mental State Examination was...

It was unclear whether sex hormone-binding globulin (SHBG) a circulating biomarker of Alzheimer's disease (AD). We tested the cross-sectional relationships between plasma SHBG and cerebrospinal fluid (CSF) AD biomarkers in 707 non-demented adults. Next, influences on dynamic changes CSF Aβ42, hippocampus volume, brain metabolism, cognition were explored 448 adults from Neuroimaging Initiative (ADNI). Finally, predictive diagnostic values explored. A positive correlation found levels CSF....

To examine whether apolipoprotein B (ApoB), A-1 (ApoA1), or their ratio (ApoB/A1) were associated with early changes in cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) pathology elderly adults subjective cognitive decline (SCD).This study included 507 objective normal participants from the Chinese Biomarker and LifestylE (CABLE) database including 288 (CN) 219 SCD. Multiple linear regression models used to associations apolipoproteins CSF AD biomarkers.Compared control...

Abstract The bridging integrator 1 ( BIN1 ) gene is the second most important susceptibility for late-onset Alzheimer’s disease (LOAD) after apolipoprotein E APOE gene. To explore whether methylation in peripheral blood changed early stage of LOAD, we included 814 participants (484 cognitively normal [CN] and 330 with subjective cognitive decline [SCD]) from Chinese Biomarker LifestylE (CABLE) database. Then tested associations promoter preclinical AD or changes cerebrospinal fluid (CSF)...

Serum uric acid (SUA) affects the reaction of oxidative stress and free radicals in neurodegenerative processes. However, whether SUA impacts Alzheimer's disease (AD) pathology remains unclear.We aimed to explore high levels can aggravate neurobiological changes AD preclinical AD.We analyzed cognitively intact participants (n = 839, age 62.16 years) who received cerebrospinal fluid (CSF) biomarkers (amyloid-β [Aβ], total tau [t-Tau], phosphorylated [p-Tau]) measurements from Chinese...