A5108058509- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- Black Holes and Theoretical Physics
- High-Energy Particle Collisions Research
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Molecular Biology Techniques and Applications
- Neutrino Physics Research
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Particle Detector Development and Performance
- Forensic and Genetic Research
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- AI in cancer detection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammatory Bowel Disease
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Mesenchymal stem cell research
- Phytochemistry and Bioactivity Studies
- Cancer Cells and Metastasis
- Metabolomics and Mass Spectrometry Studies
- Cancer Immunotherapy and Biomarkers
Jilin University
2024-2025
North China Electric Power University
2024-2025
Jilin Medical University
2024-2025
South Dakota State University
2024
Shuguang Hospital
2024
Kunming Medical University
2021-2024
Shanghai University of Engineering Science
2024
Shenzhen University
2023-2024
Shanghai University of Traditional Chinese Medicine
2024
Xiamen University
2014-2023
Accumulated evidence highlights the significance of crosstalk between epigenetic and epitranscriptomic mechanisms, notably 5-methylcytosine (5mC) N6-methyladenosine (m6A). Herein, we conducted a widespread analysis regarding 5mC m6A regulators in hepatocellular carcinoma (HCC).Pan-cancer genomic was presented at transcriptomic, genomic, epigenetic, other multi-omics levels. Hub were summarized to define an module eigengene (EME), which reflected both pre- post-transcriptional...
Abstract Emerging evidence suggests that USP39 plays an important role in the development of hepatocellular carcinoma (HCC). However, molecular mechanism by which promotes HCC progression has not been well defined, especially regarding its putative ubiquitination function. Zinc-finger E-box-binding homeobox 1 (ZEB1) is a crucial inducer epithelial-to-mesenchymal transition (EMT) to promote tumor proliferation and metastasis, but regulatory ZEB1 stability remains enigmatic. Here, we reveal...
Phytogenic compounds with anti-oxidant and anti-inflammatory properties, such as ginsenoside metabolite compound K (CK) or berberine (BBR), are currently discussed promising complementary agents in the prevention treatment of cancer inflammation. The latest study showed that Rb1 its metabolites could inhibit TNBS-induced colitis injury. However, functional mechanisms anti-inflammation effects ginsenoside, particularly CK still not clear. Here, using dextran sulfate sodium (DSS)-induced mice,...
Abstract Background Gemcitabine resistance (GR) is a significant clinical challenge in pancreatic adenocarcinoma (PAAD) treatment. Macrophages the tumor immune-microenvironment are closely related to GR. Uncovering macrophage-induced GR mechanism could help devise novel strategy improve gemcitabine treatment outcomes PAAD. Therefore, preclinical models accurately replicating patient properties essential for cancer research and drug development. Patient-derived organoids (PDOs) represent...
Ubiquitin-specific protease 39(USP39) plays an important role in modulating pre-mRNA splicing and ubiquitin-proteasome dependent proteolysis as a member of conserved deubiquitylation family. Accumulating evidences prove that USP39 participates the development hepatocellular carcinoma (HCC). However, little is known about mechanism especially deubiquitinating target regulating (HCC) growth. Here, we promotes HCC cell proliferation migration by directly deubiquitin β-catenin, key molecular...
// Weiwei Wang 1, * , Wei Zhong Jiahui Yuan 1 Congcong Yan Shaoping Hu Yinping Tong Yubin Mao 2 Tianhui Bing Zhang Gang Song Cancer Research Center, Medical College of Xiamen University, 361102, China Department Basic Medicine, These authors have contributed equally to this work Correspondence to: Song, e-mail: gangsongsd@xmu.edu.cn Keywords: cholangiocarcinoma, MSCs, metastasis, chemoresistance, β-catenin Received: April 17, 2015 Accepted: September 05, Published: October 14, ABSTRACT...
A new prenylated indole derivative 3-acetonylidene-7-prenylindolin-2-one (1) was isolated from the endophytic actinobacterium Streptomyces sp. neau-D50, together with four known hybrid isoprenoids, 7-isoprenylindole-3-carboxylic acid (2), 3-cyanomethyl-6-prenylindole (3), 6-isoprenylindole-3-carboxylic (4) and 7,4′-dihydroxy-5-methoxy-8-(γ,γ-dimethylallyl)-flavanone (5). The structures of these compounds were elucidated on basis extensive spectroscopic analysis comparison data literature....
Abstract Corilagin is a component of Phyllanthus urinaria extract and has been found possessing anti‐inflammatory, anti‐oxidative, anti‐tumour properties in clinic treatments. However, the underlying mechanisms anti‐cancer particularly its induction cell death human breast cancer remain undefined. Our research that corilagin‐induced apoptotic autophagic depending on reactive oxygen species ( ROS ) cell, it occurred MCF ‐7) only comparing with normal cells. The expression procaspase‐8,...
Our previous work has demonstrated that mesenchymal stem cells (MSCs) could induce metastatic growth of the inflammation-related cholangiocarcinoma (CCA). However, functional mechanism MSCs on CCA progression in early inflammatory microenvironment remained undetermined. Here, we showed TNF-α and IFN-γ-induced stimulated expression TNF-α, CCL5, IL-6, IDO, activated NF-κB signaling with p65 nuclear translocation cells. cell lines QBC939 Mz-chA-1 exposed to conditioned medium after being by...
This review summarizes the transformative impact of Joule heating on synthesis energy storage materials and their applications in battery electrodes, supercapacitors, solid-state electrolytes, electrode recycling current collectors.
Corilagin, a unique component of the tannin family, has been identified in several medicinal plants. In previous literature, corilagin exhibited marked anticancer property variety human cancer cells. However, biological effects on gastric and mechanisms involved remain to be fully elucidated. present study, it was reported that induced inhibition cell growth SGC7901 BGC823 cells concentration‑dependent manner. It found less toxicity towards normal GES‑1 Furthermore, study showed apoptosis...
Ubiquitin-specific protease 39 (USP39), a member of the deubiquitinating enzyme family, has been reported to participate in cytokinesis and metastasis. Previous studies determined that USP39 functions as an oncogenic factor various types cancer. Here, we is frequently overexpressed human lung cancer tissues non-small-cell (NSCLC) cell lines. knockdown inhibited proliferation colony formation A549 HCC827 cells decreased tumorigenic potential nude mice. Specifically, knocking down resulted...
Abstract Ubiquitin‐specific protease 39 (USP39) is frequently overexpressed in a variety of cancers, and involved the regulation various biological processes, such as cell proliferation, cycle progression, apoptosis pre‐messenger RNA splicing. Nevertheless, roles mechanisms USP39 colon cancer remain largely unknown. In this study, we analyzed whether can be molecular target for treatment cancer. Whilst overexpression was detected human tissues lines, knockdown observed to inhibit growth...
Developing and integrating advanced image sensors with novel algorithms in camera systems are prevalent the increasing demand for computational photography imaging on mobile platforms. However, lack of high-quality data research rare opportunity in-depth exchange views from industry academia constrain development intelligent (MIPI). With success 1st MIPI Workshop@ECCV 2022, we introduce second challenge including four tracks focusing algorithms. In this paper, summarize review Nighttime...
Abstract Uniparental-inherited haploid genetic marker of Ychromosome single nucleotide polymorphisms (Y-SNP) have the power to provide a deep understanding human evolutionary past, forensic pedigree, and bio-geographical ancestry information. Several international cross-continental or regional Y-panels instead Y-whole sequencing recently been developed promote Y-tools in practice. However, panels based on next-generation (NGS) explicitly for Chinese populations are insufficient represent...
In recent years, the studies of role microRNAs in adipogenesis and adipocyte development corresponding molecular mechanisms have received great attention. this work, we investigated function miR-140 process pathways involved, found that adipogenic treatment promoted miR-140-5p RNA level preadipocytes. Over-expression preadipocytes accelerated lipogenesis along with differentiation by transcriptional modulation adipogenesis-linked genes. Meanwhile, silencing endogenous dampened adipogenesis....