A5103164783- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Immunodeficiency and Autoimmune Disorders
- Cancer-related gene regulation
- Pharmacological Effects of Natural Compounds
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Cytokine Signaling Pathways and Interactions
- Quinazolinone synthesis and applications
- Autophagy in Disease and Therapy
- Carbon and Quantum Dots Applications
- Cancer, Lipids, and Metabolism
- Hematological disorders and diagnostics
- Phenothiazines and Benzothiazines Synthesis and Activities
- Signaling Pathways in Disease
- Medicinal Plant Pharmacodynamics Research
- Galectins and Cancer Biology
- Congenital heart defects research
Beijing Children’s Hospital
2020-2025
Capital Medical University
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2025
Affiliated Hospital of Shaanxi University of Chinese Medicine
2017-2024
Shanxi University
2021
Shaanxi University of Chinese Medicine
2016-2021
Air Force Medical University
2017-2018
Xijing Hospital
2017-2018
Nanjing Medical University
2018
Peking Union Medical College Hospital
2018
Accumulated evidence highlights the significance of crosstalk between epigenetic and epitranscriptomic mechanisms, notably 5-methylcytosine (5mC) N6-methyladenosine (m6A). Herein, we conducted a widespread analysis regarding 5mC m6A regulators in hepatocellular carcinoma (HCC).Pan-cancer genomic was presented at transcriptomic, genomic, epigenetic, other multi-omics levels. Hub were summarized to define an module eigengene (EME), which reflected both pre- post-transcriptional...
Abstract Notch ligands and receptors are frequently deregulated in several human malignancies including gastric cancer. The activation of signaling has been reported to contribute carcinogenesis progression. However, the prognostic roles individual cancer patients remain elusive. In current study, we accessed four receptors, 1–4, through “The Kaplan-Meier plotter” (KM plotter) database, which updated gene expression data survival information include a total 876 patients. All receptors’ high...
Pneumococcal meningitis is a central nervous system infection responsible for high rates of mortality and long-term disability worldwide. We aimed to summarise the clinical characteristics, as well determine risk factors progression paediatric pneumococcal (PM). This retrospective study included children with microbiologically confirmed PM who were admitted Beijing Children's Hospital between 2012 2021. The laboratory examination results characteristics enrolled patients analysed. All...
In response to the challenges of detecting and forecasting adverse geological bodies water inrush risks in long tunnels, this paper, based on comprehensive analysis seismic reflection waves electroseismic effect coupling, has achieved a long-distance tunnel construction process, detection, early warning, realized precise scale location water-containing bodies. Meanwhile, transient electromagnetic theory technology for position have been proposed, achieving medium-distance risk detection....
This study aims to investigate the effect of long non-coding RNA (lncRNA) Gas5 on proliferation, migration, invasion and apoptosis colorectal cancer (CRC) HT-29 cell line.CRC normal tissues were collected prepared from a total 126 CRC patients, intestinal epithelial line FHC lines (HCT-8, HT-29, HCT-116 SW-480) prepared. expression was detected by quantitative reverse transcriptase-polymerase chain reaction. exhibiting lowest selected for further experimentation divided into blank, negative...
Background: Celastrol is a potential anti-tumor agent in hepatocellular carcinoma (HCC). Identifying the molecular determinants of anti-HCC effect celastrol still challenging. In this study, we undertook to associate circular RNAs (circRNAs) with celastrol. Methods: Cell colony formation, proliferation, migration, invasion and apoptosis were determined using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-2H-tetrazolium bromide (MTS), transwell flow cytometry assays, respectively. The levels...
Abstract In this study, we aim to determine the function of miR‐124 on gastric cancer (GC) cells and underlying mechanism that involves jaddeg1 (JAG1) Notch signaling pathway. GC tissues adjacent from 100 patients suffering were selected. SGC‐7901 AGS selected grouped into control, mimic‐NC, mimic, inhibitor‐NC, inhibitor, inhibitor + si‐JAG1 groups. RT‐qPCR a Western blotting assay conducted detect expression miR‐124, JAG1, pathway‐related proteins (NICD, HES1, HES5). MTS, wound‐healing,...
Abstract Background Chronic active Epstein–Barr virus (CAEBV) infection is a type of lymphoproliferative disorder characterized by chronic or recurrent infectious mononucleosis (IM)-like symptoms, which can have less-frequent clinical presentations. The prognosis CAEBV poor, and hematopoietic stem cell transplantation (HSCT) has been shown to be the only potentially effective treatment. In this article, we present special case patient who had no typical IM-like symptoms at early stage, but...
Abstract Background Microarray profiles of hepatocellular carcinoma (HCC) identified that long intergenic noncoding RNA 00221 (LINC00221) was upregulated. Herein, we aimed to identify the functional significance and underlying mechanisms LINC00221 in HCC. Methods results Human HCC samples had increased expression LINC00221. Effects on cellular functions were analyzed using gain- loss-function approaches. knockdown repressed cell growth, migration, invasion enhanced their apoptosis. This...
Quercetin can significantly inhibit the progression of colorectal cancer (CRC). However, its specific mechanism remains largely unclear. In this study, we aimed to explore correlation among quercetin, tumour-associated macrophages (TAMs) and circular RNAs (circRNAs) in CRC present a novel strategy for treatment CRC. revealed that quercetin could suppress autophagy M2-TAMs induced their differentiation into M1-TAMs, by which reversed inhibition M2-TAMS on cell apoptosis promotion...
Gastric carcinoma is a malignant disease, and gastric adenocarcinoma (GAC) the most common histological type. Molecular profiling of GAC has been extensively performed, but few have focused on clinical significance gene clusters cell cycle. We investigated genetic profile cell-cycle-associated genes in cohort. The mRNA expression data were downloaded from TCGA, according to cBioportal. conducted series analyses detect relationships between these GAC. From all patients, 5 identified based 122...
Systemic Epstein–Barr virus (EBV)-positive T-cell lymphoproliferative disorders (LPDs) of childhood is a highly aggressive EBV-positive T/natural killer (NK)-cell LPD, which emerges in the background chronic active EBV infection (CAEBV) or shortly after primary acute infection. The clinical presentations CAEBV are varied; patients with atypical manifestations easily misdiagnosed. We described 14-year-old boy suffering from digestive and intermittent fever for 1 year 9 months, whose...
Chemotherapy is the standard adjuvant treatment for colon cancer. Chinese herbal formula PRM1201 improves efficacy of chemotherapy when used in combination with Cetuximab or Bevacizumab patients metastatic colorectal This study aims to explore benefits plus postoperative setting.In this parallel-group study, who had undergone curative resection stage III cancer were randomly assigned receive (FOLFOX q2w 6 months, CapeOx q3w months) (chemo+PRM1201 group) placebo (chemo+placebo group). The...
This network meta-analysis compared the short-term and long-term efficacies of first-line chemotherapy regimens in patients with advanced colorectal cancer (CRC). The 10 included folinic acid + 5-fluorouracil oxaliplatin (FOLFOX), irinotecan (FOLFIRI), gemcitabine (FFG), trimetrexate (FFT), (FF), (IROX), raltitrexed (TOMOX), tegafur-uracil (FTU), raltitrexed, capecitabine. Electronic searches were performed Cochrane Library, PubMed Embase databases from inception to June 2017. Network...
Abstract B cell expansion with NF‐κB and T anergy (BENTA) is a disease genetically linked heterozygous gain‐of‐function (GOF) mutations in the CARD11 gene an autosomal dominant expression. Hemophagocytic lymphohistiocytosis (HLH) heterogeneous group of disorders characterized by systemic inflammation hypercytokinaemia. Some BENTA patients share similar clinical manifestations as HLH various aspects, including fever splenomegaly. In this study, we reported 15‐month‐old boy diagnosed meeting...
In this study, human globular adiponectin-glucagon-like peptide-1 analog (gAd-GLP-1-A) fusion protein was expressed and its glucose-lowering effect measured in vivo.We constructed a prokaryotic expression vector PET28a-gAd-GLP-1-A transformed the into Escherichia coli BL21 (DE3).A recombinant of about 25KD from (DE3) cells after isopropylthio--D-galactoside induction.This N-terminal His-tagged gAd-GLP-1-A protein.Most inclusion body.The body purified by using High-Affinity Nickel...
In recent years, there are increasing articles concerning Epstein-Barr virus associated lymphoproliferative disorder (EBV+ LPD), and the name of EBV+ LPD is used widely. However, meaning not same, which triggered confusion understanding obstacles communication. order to solve this problem. Literature was reviewed with combination our cases clarify concept expound about it. general, it currently accepted that refers a spectrum lymphoid tissue diseases EBV infection, including hyperplasia,...
modified Sijunzi decoction is a classic prescription of traditional Chinese medicine based on benefiting qi and tonifying the spleen.It widely used in treatment malignant tumors digestive tract through clinical dialectics.At present, there have been many studies rectal cancer, including discovery that it improving immune function,reducing side effects chemotherapy toxicity patients with colorectal regulating intestinal flora.By retrieving relevant literature, this article summarizes research...
A pediatric patient suffered from renal and hepatic abscesses (through hepatorenal space) recovered by antibiotics other therapies. By clinical analysis, the multi-organ might be caused bloodstream-disseminated infection. In order to identify pathogen, we collected kidney biopsy tissue, swabs, plasma samples, used metagenomics next-generation sequencing (mNGS) some traditional methods. The results revealed that polymicrobial especially anaerobic bacteremia (Bacteroides fragilis, et al.)...
Abstract By retrieving the 1900–2016 medical education-related essays from web of science database, UCINET software was used to build national cooperation network and its nested visualization software, NetDraw visualize country networks in different time windows. We found that international education papers began show exponential growth until 1945 did not begin become dense 1961. With increasing number participating countries education, factions formed more complicated. The intensity between...