A5058593919- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Circadian rhythm and melatonin
- Immune Cell Function and Interaction
- Genetics, Aging, and Longevity in Model Organisms
- Cytomegalovirus and herpesvirus research
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- T-cell and Retrovirus Studies
- Fibroblast Growth Factor Research
- Adipokines, Inflammation, and Metabolic Diseases
- Chronic Lymphocytic Leukemia Research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Molecular Biology Techniques and Applications
- Ubiquitin and proteasome pathways
- Virus-based gene therapy research
- Lipid metabolism and biosynthesis
- Cutaneous lymphoproliferative disorders research
- Monoclonal and Polyclonal Antibodies Research
- Histone Deacetylase Inhibitors Research
- Cholesterol and Lipid Metabolism
- Tissue Engineering and Regenerative Medicine
- Transplantation: Methods and Outcomes
Beijing Friendship Hospital
2018-2025
Capital Medical University
2018-2025
Education Department of Heilongjiang Province
2020-2023
Northwest A&F University
2019-2023
Oleic acid is an abundant free fatty present in livestock that are a negative energy-balance state, and it may have detrimental effects on female reproduction fertility. induces lipid accumulation bovine granulosa cells, which leads to foam cell-like morphology reduced steroidogenesis. However, why oleic increases but decreases steroidogenesis remains unclear. This study focused acid's type steroidogenesis.Oleic increased the concentration-dependent manner mainly triglyceride level decreased...
The differential diagnosis between adult systemic EBV-positive T-cell lymphoproliferative disorders (EBV+ T-LPD) and angioimmunoblastic lymphoma (AITL) with multiple EBV infections is difficult, distinguishing the two has become a diagnostic challenge for pathologists. Given that clinical treatment plans are different, an accurate prerequisite to ensure effective treatment, therefore, it extremely necessary meaningful find pathological indicators diseases. We present retrospective study...
Granulosa cells (GCs) proliferation and estradiol synthesis significantly affect follicular development. The miR-214-3p expression in the ovarian tissues of high-yielding sows is higher than that low-yielding sows, indicating may be involved sow fertility. However, functions mechanisms on GCs are unclear. This study focuses terms effects synthesis.Our findings revealed promotes inhibits porcine GCs. MiR-214-3p can increase percentage S-phase cells, number EdU labeled positive cell viability....
With the improvement of people's living standards, number obese patients has also grown rapidly. It is reported that level oxidative stress in significantly increased, mainly caused by increase reactive oxygen species (ROS) levels adipose tissue. Studies have shown use siRNA to interfere with bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) expression could promote adipocyte differentiation, under hypoxic conditions, BAMBI act as a regulator HIF1α regulate polarity...
Proliferation and apoptosis are important physiological processes of preadipocytes. Rev-erbα is a circadian clock gene, its activity contributes to several in various cells. Previous studies demonstrated that promotes preadipocyte differentiation, but role on proliferation has not been demonstrated. GSK4112 often used as an agonist Rev-erbα. In this study, we explore the effects by RT-qPCR, Western blot, Cell Counting Kit-8 (CCK8) measurement, 5-Ethynyl-2′-deoxyuridine (EdU) staining,...
Systemic Epstein–Barr virus (EBV)-positive T-cell lymphoproliferative disorders (LPDs) of childhood is a highly aggressive EBV-positive T/natural killer (NK)-cell LPD, which emerges in the background chronic active EBV infection (CAEBV) or shortly after primary acute infection. The clinical presentations CAEBV are varied; patients with atypical manifestations easily misdiagnosed. We described 14-year-old boy suffering from digestive and intermittent fever for 1 year 9 months, whose...
Clock circadian regulator (CLOCK) is a core factor of the mammalian biological clock system in regulating female fertility and ovarian physiology. However, CLOCK's specific function molecular mechanism porcine granulosa cells (GCs) remain unclear. In this study, we focused on effects GC proliferation.CLOCK significantly inhibited cell proliferation GCs. CLOCK decreased expression cycle-related genes, including CCNB1, CCNE1, CDK4 at mRNA protein levels. CDKN1A levels were upregulated by...
Lack of estradiol production by granulosa cells blocks follicle development, causes failure estrous initiation, and results in an inability to ovulate. The ubiquitin-proteasome system plays a critical role maintaining protein homeostasis stability the cycle, but knowledge deubiquitination enzyme function synthesis is limited. Here, we observe that deubiquitinase ubiquitin C-terminal hydrolase 1 (UCHL1) more significant sows high litter-size than nonestrous low-yielding sows. Overexpression...
Objective To study the role of pathogenic microorganisms commonly associated with chronic eye disease, including Chlamydia psittaci, trachomatis, pneumoniac, herpes simplex virus (HSV) type 1 and 2, adenovirus 8 19, in development primary ocular adnexul mucosa-associated lymphoid tissue (MALT) lymphoma Chinese patients. Methods Sixty-eight archival cases adnexal lymphoproliferative lesions, 38 MALT lymphoma, 3 non-MALT 27 inflammation, were enrolled into study. DNA was extracted from...
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematopoietic malignancy mainly affecting elderly patients. It highly responsive to chemotherapy, but the median event-free survival very short has high rate of relapse even after performing allogeneic stem transplantation; thus, discovery novel agents for treatment BPDCN urgent. Chidamide new oral isotype-selective histone deacetylase inhibitor (HDACi). proved exert well-characterized anticancer property in wide...
Objective To investigate clinicopathological and genetic characteristics of primary ocular adnexal lymphoproliferative lesions.Methods Clinical,morphological immunohistochemical features 37 archival cases lesions were studied including 5 reactive lymphoid hyperplasia 32 lymphomns retrospectively.Classification the lymphomas made according to WHO classification tumors haematopeietic tissues.All by interphase fluorescence in situ hybridization (FISH) using dual color break apart probes...
在临床病理诊断工作中,淋巴组织疾病最容易出现误诊[1].一方面是将增生性病变误诊成淋巴瘤,另一方面是将淋巴瘤误诊成非淋巴瘤.由于误诊将疾病的性质搞错,后果自然严重.从实际工作中遇到的病例来看,将淋巴瘤误诊成非淋巴瘤的情况相对较少,而更多的是将淋巴组织增生性病变误诊为淋巴瘤,其中急性淋巴结T区增生性病变(简称急性T区增生)的误诊频率非常高。
OBJECTIVE To study the clinical and pathologic features of post-transplant lymphoproliferative disorders (PTLD), to investigate significance this diagnosis. METHODS Four cases PTLD were studied by routine light microscopy, immunohistochemistry in-situ hybridization polymerase chain reaction. The data follow-up information also reviewed. RESULTS In 4 cases, 3 occurred in renal transplant recipients 1 bone marrow patient. post-renal patients, 2 had polymorphic monomorphic PTLD. post-bone case...
Epstein-Barr病毒(EBV)属于疱疹病毒γ亚科,1964年由Epstein和Barr首次在Burkitt淋巴瘤细胞株中发现[1].EBV通过唾液传播,正常人群中感染率在90%以上,感染后终生携带EBV.EBV与多种疾病有关,有的仅有轻微症状,如同普通感冒;有的出现明显的全身性症状并呈自限性临床过程,如传染性单核细胞增多症(IM)[2];有的表现为长期反复发作的临床过程,并可进展为淋巴瘤,如慢性活动性EBV感染(CAEBV)[3];有的与肿瘤有明确关系,如Burkitt淋巴瘤、鼻型NK/T细胞淋巴瘤和霍奇金淋巴瘤等[1]。
1.病例简介:患者男,34岁.无明显诱因出现活动后乏力、气短,自觉头晕、头痛9个月入院.体检无明显异常.血常规示红细胞及白细胞减少,分片偶见原始细胞.骨髓穿刺示原始+幼稚淋巴细胞占59%.流式细胞学免疫分型CD33、CD7、CD11b、CD19、CD5、CD2、CD3阳性.染色体未见异常.临床诊断为急性淋巴细胞性白血病,双表型.于确诊后7个月进行骨髓同种异体干细胞移植.移植后给予环孢酰胺免疫抑制剂治疗,病情平稳.于移植后第55天检查发现患者右颈后可触及肿大淋巴结2枚,大小均约1.5 cm×1.0 cm.临床考虑:(1)白血病髓外复发;(2)病毒感染;(3)淋巴瘤.因患者移植术后2个月,尚未出无菌舱,不宜手术摘取淋巴结送检,因此于无菌舱内应用友谊式穿刺针[1]穿刺肿大淋巴结获取尽可能多标本,除制成1张细胞涂片外,剩余组织全部制成细胞块,常规切片,HE染色、免疫细胞化学染色及EB病毒原位杂交染色。
Abstract Background: The proliferation and estradiol synthesis in granulosa cells (GCs) directly promotes follicular development. Previous studies had found that FGF21 regulated the hypothalamic-pituitary-gonad axis response to control of fertility. However, functions mechanisms GCs are unclear. Results: Here, we mRNA protein levels ovarian tissue high-yielding sows ( Sus scrofa ) was higher than low-yielding sows. Moreover, predominantly expressed porcine GCs. Additionally, ELISA assay...