A5101453485- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Advanced Nanomaterials in Catalysis
- Cancer Treatment and Pharmacology
- Cancer Research and Treatments
- Carbon and Quantum Dots Applications
- Prostate Cancer Treatment and Research
- Extracellular vesicles in disease
- Genetics and Plant Breeding
- Parasitic infections in humans and animals
- Nanocluster Synthesis and Applications
- Polymer Surface Interaction Studies
- Process Optimization and Integration
- Enzyme Structure and Function
- Biomarkers in Disease Mechanisms
- Inflammatory Bowel Disease
- Advanced Polymer Synthesis and Characterization
- Advanced Breast Cancer Therapies
- GABA and Rice Research
- Viral-associated cancers and disorders
- Drug Transport and Resistance Mechanisms
- Amoebic Infections and Treatments
China Pharmaceutical University
2019-2024
Medical Center Hospital
2024
Hebei General Hospital
2024
Lanzhou Veterinary Research Institute
2022-2023
Chinese Academy of Agricultural Sciences
2022-2023
Gansu Agricultural University
2023
North University of China
2022
University of Pittsburgh
2021
Beijing Children’s Hospital
2020
Capital Medical University
2020
Lysine acetylation and its regulatory enzymes are known to have pivotal roles in mammalian cellular physiology. However, the extent function of this modification prokaryotic cells remain largely unexplored, thereby presenting a hurdle further functional study systems. Here we report first global screening lysine acetylation, identifying 138 sites 91 proteins from Escherichia coli. None has been previously associated with modification. Among identified transcriptional regulators, as well...
Nitric oxide (NO), as a bioeffector to improve chemosensitivity by reversing multidrug resistance (MDR), is highly attractive for developing combinational delivery systems deal with MDR tumors, while it challenged the stability and controlled release of NO during pathway. Here we design synthesize cyclic nitrate trimethylene carbonate monomer (NTC), followed ring-opening polymerization prepare amphiphilic biodegradable polycarbonate-based copolymers polymeric donors tailored contents. The...
This study aimed to determine the diagnostic accuracy of CA125, HE4, systemic immune-inflammation index (SII), prognostic nutritional (PNI), fibrinogen-to-albumin ratio (FAR), neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR), and combination six inflammatory-nutritional markers for ovarian cancer (OC) identify best indicator OC early diagnosis. An extensive was performed establish connection between these indicators pathological aspects OC.
Abstract Background Chronic active Epstein–Barr virus (CAEBV) infection is a type of lymphoproliferative disorder characterized by chronic or recurrent infectious mononucleosis (IM)-like symptoms, which can have less-frequent clinical presentations. The prognosis CAEBV poor, and hematopoietic stem cell transplantation (HSCT) has been shown to be the only potentially effective treatment. In this article, we present special case patient who had no typical IM-like symptoms at early stage, but...
The precise delivery of multiple drugs to their distinct destinations plays a significant role in safe and efficient combination therapy; however, it is highly challenging simultaneously realize the targets overcome intricate biological hindrances using an all-in-one nanosystem. Herein, cascade-responsive hierarchical nanosystem containing checkpoint inhibitor anti-PD-L1 antibody (αPD-L1) paclitaxel (PTX) developed for spatially programed overcoming pathway barriers. nanoparticles (MPH-NP@A)...
Multidrug resistance (MDR) is one of the leading causes failure cancer chemotherapy and mainly attributed to overexpression drug efflux transporters in cells, which dependent on adenosine triphosphate (ATP). To overcome this phenomenon, herein, a mitochondrial-directed pH-sensitive polyvinyl alcohol (PVA) nanogel incorporating hexokinase inhibitor lonidamine (LND) chemotherapeutic paclitaxel (PTX) was developed restore activity PTX synergistically treat drug-resistant tumors. The...
Chemotherapy predominates in clinical treatment of prostate cancer (PCa), while irreversible resistance to chemotherapeutics and severe side effects hinder the therapeutic efficacy, especially castration-resistant PCa (CRPC). Herein, a bombesin (BBN)-decorated two-in-one prodrug (T-NO/E2-PMs) incorporating polymeric nitric oxide (NO) donor acetal-linked 17β-estradiol (E2) one backbone is developed, aiming inhibit androgen receptor (AR) expression, reprogram tumor microenvironment CRPC,...
Graphene quantum dots (GQD) could significantly enhance the chemiluminescence (CL) reaction of Ce(IV) with NaHSO 3 through energy and electron transfer. The resonance transfer (CRET) occurred between SO 2 * / 1 O GQD, radiative electron–hole annihilation came from combining hole‐injected GQD (GQD •+ ) electron‐injected •– ). Tyrosine (Tyr) is easily oxidized by OH • Ce(IV), which results in decrease CL intensity GQD–Ce(IV)–NaHSO system inhibited Tyr. In this way, GQD‐based as a sensitive...
Echinococcosis is a parasitic disease caused by the metacestodes of Echinococcus spp. The has long latent period and largely underdiagnosed, partially because lack effective early diagnostic approaches. Using liquid chromatography-mass spectrometry, we profiled serum-derived extracellular vesicles (EVs) E . multilocularis -infected mice identified three parasite-origin proteins, thioredoxin peroxidase 1 (TPx-1), transitional endoplasmic reticulum ATPase (TER ATPase), 14-3-3, being...
Accurate comprehension of thermodynamic demeanor and pressure pulsation propagation is great attractiveness in a reciprocating compressor system. To consider the reciprocal interaction between pipelines, hybrid numerical model thus built by coupling in-cylinder lumped parameter approach, in-pipe 1D gas dynamics 3D acoustic characteristics chambers. The transmission reflection coefficients geometrically complex chamber are achieved definition an characterization method based on FEM simulation...
Chemiluminescence (CL) of copper nanoclusters (CuNCs) induced by cerium (IV) (Ce(IV)) or potassium permanganate (KMnO4 ) in acidic medium was observed. The potential application CuNCs CL analytical chemistry also demonstrated using trihexyphenidyl hydrochloride (THP) as an example based on its enhancing intensity for the CuNCs-Ce(IV)/KMnO4 systems. excited state acted a luminophore CuNCs-Ce(IV) system, while played role reductant CuNCs-KMnO4 system. increased Ce(IV)-CuNCs system proportional...
Design and synthesis of degradable chimeric polymersomes based on zwitterionic PAC(DMA)-PCL-PMDMSA triblock copolymers for high protein loading intracellular delivery.
Abstract Background: Eribulin has been widely used for the treatment of metastatic breast cancer (MBC). It found that eribulin can work in synergy with Bevacizumab or Anlotinib to achieve anti-angiogenic effects and possible synergistic enhancement. To optimize efficacy usage late-line MBC patients, it is essential delve deeper into combined treatments gather more real-world clinical outcomes. Therefore, we evaluated safety plus drugs patients. Objective: This study aims retrospectively...
Objective: To evaluate the efficacy and safety of eribulin plus anti-angiogenic medicine in metastatic breast cancer (MBC), explore potential biomarkers.Study Design: Observational study.
To determine the efficacy and safety of Yinmei Kuijie decoction combined with 5-aminosalicylic acid (5-ASA) in treating mildly to moderately active ulcerative colitis (UC) under real-world conditions. This multicenter, prospective, non-randomized, observational study will be conducted settings. A total 204 eligible patients consecutively enrolled study. Patients combination treatment group receive 5-ASA, whereas those control treated 5-ASA alone. The primary endpoint a clinical response at...