A5076852752- Developmental Biology and Gene Regulation
- Congenital heart defects research
- Muscle Physiology and Disorders
- Pluripotent Stem Cells Research
- Animal Genetics and Reproduction
- Cell Adhesion Molecules Research
- Neurogenetic and Muscular Disorders Research
- Cellular Mechanics and Interactions
- Wnt/β-catenin signaling in development and cancer
- Tissue Engineering and Regenerative Medicine
- Renal and related cancers
- Genomics and Chromatin Dynamics
- Chemokine receptors and signaling
- Healthcare professionals’ stress and burnout
- Skin and Cellular Biology Research
- Connective tissue disorders research
- RNA Research and Splicing
- Mesenchymal stem cell research
- Axon Guidance and Neuronal Signaling
- Silk-based biomaterials and applications
- Prenatal Screening and Diagnostics
- Hedgehog Signaling Pathway Studies
- Medical Education and Admissions
- Proteoglycans and glycosaminoglycans research
- Congenital limb and hand anomalies
Ruhr University Bochum
2016-2025
Sorbonne Université
2009-2021
Centre de Recherche des Cordeliers
2021
Université Paris Cité
2021
Inserm
2021
University of Freiburg
2004-2014
Zahnklinik Bochum
2014
University Hospital in Halle
2014
Centre National de la Recherche Scientifique
2009
Max Delbrück Center
2005
Abstract Hypaxial skeletal muscles develop from migratory and non-migratory precursor cells that are generated by the lateral lip of dermomyotome. Previous work shows formation precursors requires c-Met SF/HGF genes. We show here in mice lacking or SF/HGF, initial development dermomyotome proceeds appropriately growth survival not affected. Migratory also correctly specified, as monitored expression Lbx1. However, these remain aggregated fail to take up long range migration. conclude...
Long-range migrating progenitor cells generate hypaxial muscle, for instance the muscle of limbs, hypoglossal cord, and diaphragm. We show here that progenitors express chemokine receptor CXCR4 . The corresponding ligand, SDF1 , is expressed in limb branchial arch mesenchyme; i.e., along routes at targets migratory cells. Ectopic application chick attracts In mutant mice, number colonize anlage tongue dorsal was reduced. Changes distribution were accompanied by increased apoptosis,...
Abstract Gastric cancer is the second leading cause of cancer-related death worldwide. RNA nanotechnology has recently emerged as an important field due to recent finding its high thermodynamic stability, favorable and distinctive in vivo attributes. Here we reported use thermostable three-way junction (3WJ) bacteriophage phi29 motor pRNA escort folic acid, a fluorescent image marker BRCAA1 siRNA for targeting, imaging, delivery, gene silencing regression gastric animal models. In vitro...
In vitro culture systems that structurally model human myogenesis and promote PAX7 + myogenic progenitor maturation have not been established. Here we report skeletal muscle organoids can be differentiated from induced pluripotent stem cell lines to contain paraxial mesoderm neuromesodermal progenitors develop into organized structures reassembling neural plate border dermomyotome. Culture conditions instigate lineage arrest fetal hypaxial toward limb axial anatomical identity, with...
Abstract In recent years, there has been a growing trend toward the digitization of education, highlighting need to understand how different learning modalities impact medical student outcomes. This study analyzes user behavior among students in Microscopic Anatomy, focusing on preferences for digital versus face‐to‐face guided self‐study. A cohort 684 participated Anatomy courses, choosing between and self‐study sessions. Student participation was systematically tracked, capturing detailed...
We have studied the angiogenic potential of unsegmented paraxial mesoderm and epithelial somites trunk with homotopical grafts between quail chick embryos. Quail endothelial cells were stained QH-1 antibody after 1-6 days reincubation. The all parts somite found to contain angioblasts which develop into positive cells. These are incorporated lining host's blood vessels such as perineural vascular plexus dorsal branches aorta. There is a certain preference concerns location derived from...
The somites of vertebrate embryos give rise to sclerotomes and dermomyotomes. form the axial skeleton, whereas dermomyotomes all trunk muscles dermis back. ribs were thought be ventral processes skeleton therefore derived from sclerotomes; however, recently a dermomyotomal origin distal rib (the costal shaft) was suggested, with only proximal parts (head neck rib) being sclerotomal origin. We have re-investigated development in quail-chick chimeras carried out three experimental series. (1)...
The somites develop from the unsegmented paraxial mesoderm that flanks neural tube. They form in an intrinsic process which lays down primary segmental pattern of vertebrate body. We review processes somitogenesis and somite differentiation as well mechanisms involved these developmental events. Long before overt occurs, different compartments still epithelial give rise to special cell lines particular derivatives. By means isotypic grafting between quail chick embryos, it is possible follow...
Over the recent years, an increased alertness for thorough knowledge of anatomical variants with clinical significance has been recorded in order to minimize risks surgical complications. We report a rare case bilateral strap-like sternalis muscle anterior chest wall female cadaver. Its presence may evoke alterations electrocardiogram or confuse routine mammography. The incidental finding mammography, CT, and MRI studies must be documented patient's medical records as it can used pedicle...
Abstract Scatter factor/hepatocyte growth factor (SF/HGF) is known to be involved in the detachment of myogenic precursor cells from lateral dermomyotomes and their subsequent migration into newly formed limb buds. As yet, however, nothing has been about role persistent expression SF/HGF bud mesenchyme during later stages development. To test for a potential early muscle patterning, we examined regulation as well influence on direction control mesenchyme. We demonstrate that controlled by...