A5078766606- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Pleural and Pulmonary Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Brain Metastases and Treatment
- Neutropenia and Cancer Infections
- Lung Cancer Research Studies
- Hematopoietic Stem Cell Transplantation
- Cutaneous lymphoproliferative disorders research
- Pharmacology and Obesity Treatment
- Plasma Applications and Diagnostics
- CAR-T cell therapy research
- Sarcoma Diagnosis and Treatment
- Muscle and Compartmental Disorders
- Autoimmune Neurological Disorders and Treatments
- Polymer composites and self-healing
- Head and Neck Surgical Oncology
- Pregnancy and Medication Impact
- Blood Pressure and Hypertension Studies
- Hematological disorders and diagnostics
- Nigella sativa pharmacological applications
First Hospital of Jilin University
2013-2025
Jilin University
2013-2025
Chongqing Medical University
2024
University of Manchester
1992
Wythenshawe Hospital
1991
Abstract Specific induction of endoplasmic reticulum (ER) stress‐initiated type‐II immunogenic cell death (ICD) shows great potential in boosting tumor immunogenicity and anti‐tumor immunotherapy. However, it remains challenging to selectively provoke ICD, due the lack highly efficient ER targeting strategy. Here, a pH/Cathepsin‐Activatable Nanoplatform (PCAN) is reported specifically photo‐induce stress (PCAN ) ICD for cancer PCAN integrates long‐circulating properties nanomedicines with...
This study was to determine the efficacy of vincristine and irinotecan in children with relapsed hepatoblastoma (HB).A total 10 patients HB were enrolled. Three excluded. Patients received 50 mg/m(2)/day, day 1-5 1.5 1, repeated every 3 weeks. The maximum cycles eight. Reevaluation tumor performed two cycles. primary outcome rate complete resection. Secondary outcomes event-free survival (EFS) overall (OS).Of seven assessable for response, one patient normal AFP level showed a progressive...
The prognostic value of immune-related genes and lncRNAs in neuroblastoma has not been elucidated, especially subgroups with different outcomes. This study aimed to explore signatures.Immune-related were identified by univariate Cox regression analysis the training set. top 20 C-index 17 included model construction, random forest Least Absolute Shrinkage Selection Operator (LASSO) algorithms employed select features. risk score was constructed assessed using Kaplan-Meier plot receiver...
Severe nephrotoxicity greatly limits the clinical use of common effective chemotherapeutic agent cyclophosphamide (CYP). Huaiqihuang (HQH) is a Chinese herbal complex with various pharmacological activities, widely used for treating kidney disease.This study estimates protective effect HQH against CYP-induced in rats.Four groups 10 Sprague-Dawley rats were pre-treated once-daily oral gavage 3 and 6 mg/kg 5 days before receiving single dose CYP (200 i.p.) on 5th day; control group received...
Clinical presentations of paraneoplastic syndromes in neuroblastoma may multiply. Review the clinical data and literature on this syndrome help diagnosis neuroblastoma.In order to make more accurate diagnosis, we reviewed syndrome.Between April 2007 2012, 68 children were diagnosed with or ganglioneuroblastoma our institution, 9 which presented exclusively not treated chemotherapy prior diagnosis. After all patients received operation NB97 protocol.Among pediatric ganglioneuroblastoma, 4...
There is no consensus about how to manage pulmonary metastasis in patients with hepatoblastoma. We reviewed a treatment combination of oxaliplatin, vincristine, and topotecan (OVT) paired radiofrequency ablation (RFA) 12 multiple refractory / recurrent hepatoblastoma.The medical records from ≤21 years age presenting deposits (≥2) hepatoblastoma were reviewed. The following data extracted each patient: age, gender, histological subtyping, cycles OVT, tumor size, biomarkers, chemotherapy...
Hospitalized hypertensive patients rely on blood pressure medication, yet there is limited research the sole use of amlodipine, despite its proven efficacy in protecting target organs and reducing mortality. This study aims to identify key indicators influencing thereby enhancing treatment outcomes.
Abstract Background Accurate molecular and clinical stratification of patients with central nervous system (CNS) non‐germinomatous germ cell tumors (NGGCTs) remains challenging, impeding the development personalized therapeutic approaches. Herein, we investigated translational significance cerebrospinal fluid (CSF) circulating tumor DNA (ctDNA) in pediatric NGGCTs to identify characteristic features CNS a subset for whom presence residual disease is risk factor an indicator shorter...
Chemotherapy is commonly used for treatment in children over three years old with high-risk medulloblastoma(MB). However, little currently known about the therapeutic benefits and side effects of intrathecal methotrexate(MTX), warranting further research.In this retrospective study, patients who received MTX during chemotherapy were included group (n = 32), that only underwent cerebrospinal fluid (CSF) cytology analysis assigned to control 14).In group, 27(84.38%) had metastatic disease,...
Neuroblastoma (NB) is the most common solid tumor apart from central nervous system malignancies in children aged 0–14 years, and outcomes of high-risk patients are dismal. High mobility group box 3 (HMGB3) plays an oncogenic role many cancers; however, its biological NB still unclear. Using data mining, we found that HMGB3 expression was markedly elevated with unfavorable prognoses. When cell lines inhibited, proliferation, migration, invasion were suppressed, knockdown inhibited...
Capillary leak syndrome (CLS) is a rare but fatal disease, which has been reported following the infusions of interleukin-2, tumor necrosis factor, granulocyte-colony stimulating certain monoclonal antibodies, and gemcitabine, suggesting that drugs can also cause CLS. In this study, seven Wilm's cases with CLS had presented, was suggested to be caused administration vincristine (VCR). From January 1st, 2014 December 31st, 2016, medical records from patients were reviewed identify those...
Currently, no available coherent management protocol exists for pediatric cancers associated with pleural effusion, ascites, and pericardial effusion. This study aimed to retrospectively present our experience in treating cancer patients effusion using interleukin-2 (IL-2) dexamethasone (DEX) intracavitary injections.Between January 1st, 2008 December 31st, 2020, medical reports of diagnosed solid tumors or lymphoma were checked identify > 2 cm and/or more than grade 1 small Patients...