A5100433460- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Advanced Nanomaterials in Catalysis
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Biosensors and Analytical Detection
- Cancer Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Molecular Junctions and Nanostructures
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Photodynamic Therapy Research Studies
- Synthesis of Organic Compounds
- Dendrimers and Hyperbranched Polymers
- DNA and Nucleic Acid Chemistry
- Electrochemical Analysis and Applications
- Advanced Drug Delivery Systems
- Intraperitoneal and Appendiceal Malignancies
- Gold and Silver Nanoparticles Synthesis and Applications
- Ginseng Biological Effects and Applications
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Ultrasound and Cavitation Phenomena
Chinese Academy of Sciences
2015-2025
Fujian Institute of Research on the Structure of Matter
2025
Xinyang Normal University
2025
University of Science and Technology of China
2024
Changchun Institute of Applied Chemistry
2020-2023
Shanghai Institute of Materia Medica
2023
Shanghai Advanced Research Institute
2020-2023
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2023
Wenzhou Medical University
2023
University of Shanghai for Science and Technology
2023
Hypoxia, and hypoxia inducible factor-1 (HIF-1), can induce tumor resistance to radiation therapy. To overcome hypoxia-induced resistance, recent studies have described nanosystems improve oxygenation for immobilizing DNA damage simultaneously initiate oxygen-dependent HIF-1α degradation. However, degradation is incomplete during treatment alone. Therefore, combined with residual HIF-1 functional inhibition crucial optimizing therapeutic outcomes of radiotherapy. Here, a reactive oxygen...
The crosstalk between tumor and stroma cells is a central scenario in the microenvironment (TME). While predominant effect of on immune establishing an immunosuppressive context, cell death at certain conditions will boost antitumor immunity. Herein, we report rationally designed specific enhanced oxidative stress polymer conjugate (TSEOP) for boosting TSEOP prepared by Passerini reaction cinnamaldehyde (CA), 4-formylbenzeneboronic acid pinacol ester, 5-isocyanopent-1-yne, followed...
Using nanotechnology for improving the immunotherapy efficiency represents a major research interest in recent years. However, there are paradoxes and obstacles using single nanoparticle to fulfill all requirements complicated immune activation processes. Herein, supramolecular assembled programmable nanomedicine (PIAN) sequentially finishing multiple steps after intravenous injection eliciting robust antitumor immunity situ is reported. The constructed by assembly via host-guest...
The use of functional nanodiamonds (fNDs) to deliver CpG oligonucleotides (ODNs) for sustained immunostimulation is reported. It demonstrated that monotherapy using this immunostimulatory agent significantly suppresses the tumor growth in two murine models. This fND-based nanoagent opens new opportunities immunotherapy, as well clinical applications various types therapeutic nucleic acids. As a service our authors and readers, journal provides supporting information supplied by authors. Such...
Abstract Precise discrimination and eradication of cancer cells by immune independent antigen recognition is promising for solid tumor therapeutics, yet remains a tremendous challenge. Inspired neutrophils, here we design construct nanodevice based on the differential histone H1 isoform expression. In this nanodevice, neutrophil membrane camouflage glutathione (GSH)-unlocking effect Fe-porphyrin metal−organic framework structure ensures selectivity to cells. The released porcine pancreatic...
In this work, smart near-infrared (NIR) light/H2O2-triggered and O2-evolving nanocomposites were designed applied for efficient production of (1)O2 by converting a deeply penetrating NIR light into visible to excite the photosensitizers achieve self-sufficiency O2 generation in photodynamic therapy process overcome hypoxia-induced drug resistance.
Open AccessCCS ChemistryRESEARCH ARTICLE1 Dec 2020A ROS-Responsive Aspirin Polymeric Prodrug for Modulation of Tumor Microenvironment and Cancer Immunotherapy Sheng Ma, Wantong Song, Yudi Xu, Xinghui Si, Yu Zhang, Zhaohui Tang Xuesi Chen Ma Key Laboratory Polymer Ecomaterials, Changchun Institute Applied Chemistry, Chinese Academy Sciences, 130022 University Science Technology China, Hefei 230026 Jilin Biomedical Polymers Engineering Laboratory, , Song *Corresponding authors: E-mail Address:...
Schematic illustration of the synthetic process Fe<sub>3</sub>O<sub>4</sub>@MnO<sub>2</sub>–Ce6/CSL and mechanism cellular uptake pH-/H<sub>2</sub>O<sub>2</sub>-triggered MRI/FL imaging CT/PDT combination treatment.
Biomineralization is a normal physiological process that includes nucleation, crystal growth, phase transformation, and orientation evolution. Notably, artificially induced biomineralization in the tumor tissue has emerged as an unconventional yet promising modality for malignancy therapy. However, modest ion-chelating capabilities of carboxyl-containing initiators lead to deficient blockade, thus compromising antitumor efficacy. Herein, biomineralization-inducing nanoparticle (BINP)...
The advent of DNA technology has demonstrated great potential in a wide range applications, especially the field biology and biomedicine. However, current understanding toxicological effects cellular responses nanostructures remains to be improved. Here, we chose tetrahedral (TDNs), type nanocarriers for delivering molecular drugs, as model systematic live-cell analysis biocompatibility TDNs normal bronchial epithelial cells, carcinoma macrophage. We found that interaction behaviors...
DTX/CS–Rh–PFC nanoparticles are hydrolyzed by glutathione in tumor cells, releasing DTX and oxygen molecules, thus exhibit good anti-tumor ability.
Surgery remains the most preferred treatment options for colorectal cancer (CRC). Paradoxically, local recurrence and distant metastasis are usually accelerated postsurgery as a consequence of systemic immunosuppression caused by surgery. Therefore, modulating tumor postoperative immune microenvironment activating antitumor immunity necessary supplementaries CRC therapy. Here, an in-situ-sprayed immunotherapeutic gel loaded with anti-OX40 antibody (iSGels@aOX40) is reported postsurgical...
Recent advances in tumor immunotherapy mainly tend to remodel the immunosuppressive microenvironment (TME) for immune enhancement. However, complexity of TME makes it unlikely achieve satisfactory therapeutic effects with any single intervention alone. Here, we focus on exposing intrinsic features cells trigger direct pleiotropic antitumor immunity. We develop a photosensitive nanointerferer that is engineered nanoscale metal-organic framework decorated cell membranes targeted delivery...
High-entropy materials are poised to revolutionize science and industrial applications due their design flexibility, peculiar performance, broad applicability. In this study, we present a proof-of-concept high-entropy engineered nanocarbon (HENC) co-doped with five nonmetal elements (B, F, P, S, N), synthesized via in situ polymerization modification of ZIF-8 followed by pyrolysis. The HENC exhibits outstanding performance as electrocatalyst for the oxygen reduction reaction (ORR), activity...
Abstract Lytic cell death triggers an antitumour immune response. However, cancer cells evade lytic by several mechanisms. Moreover, a prolonged and uncontrolled response conversely leads to T-cell exhaustion. Therefore, oncolytic system capable of eliciting killing in controlled manner is needed. Here, we establish micro-scale cytotoxic T-cell-inspired (TIOs) precisely lyse NIR-light-controlled lipid peroxidation. Our TIOs present antigen-based recognition, tumour-targeting catalytic...
Ultrasonic technology is a promising tool for washing oily sludge to recover oil. In this study, the influence of ultrasonic conditions on removal different oil components from was investigated optimize technology. Among three frequencies (25, 50 and 100 kHz) applied, at 25 kHz exhibited best performance in terms extraction rate efficiency. An intensity 0.33 W/cm2 necessary overcome energy threshold washing. Application standing wave or dual did not improve perceptibly. The optimum were an...
In this study, an enhanced anticancer strategy combining the chemotherapy from antineoplastics with oxidative damage a sulfur dioxide (SO2) prodrug is presented. Based on characteristics of high glutathione (GSH) level in tumor microenvironment, novel GSH-responsive SO2 polymeric mPEG-b-P(PA-alt-GDNs) was designed and synthesized via ring-opening alternating copolymerization "click" reaction. The GSH-sensitive mechanism polymer investigated detail. Furthermore, Irinotecan loaded into...
Inflammation has been reported as one significant hallmark of breast cancer in relation to tumor development, metastasis, and invasion. The bradykinin receptor 1 (B1R) is highly expressed on inflammatory cells thus providing a promising targeting site for recognition sufficient mediated endocytosis. In this study, the authors evaluate efficiency l-form d-form [des-Arg10 ]kallidin both vitro vivo. To further improve drug delivery efficiency, establish dandelion like nanoparticle by combining...
We developed biocompatible ATP responsive DNA nanogels, by grafting strands on carboxymethyl chitosan polymer chains, and then hybridizing with aptamers to form core–shell nanogels.