A5103202149- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Receptor Mechanisms and Signaling
- Cancer-related molecular mechanisms research
- Mosquito-borne diseases and control
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Viral Infections and Vectors
- Neurological Disease Mechanisms and Treatments
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Solar and Space Plasma Dynamics
- Vector-borne infectious diseases
- Nitric Oxide and Endothelin Effects
- Vector-Borne Animal Diseases
- Monoclonal and Polyclonal Antibodies Research
- Mesenchymal stem cell research
- Neuroendocrine Tumor Research Advances
- Reproductive System and Pregnancy
- Peroxisome Proliferator-Activated Receptors
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Cannabis and Cannabinoid Research
- Cancer Immunotherapy and Biomarkers
University of Pittsburgh
2023-2025
VA Pittsburgh Healthcare System
2023-2024
Geriatric Research Education and Clinical Center
2023-2024
Mianyang Central Hospital
2024
University of Electronic Science and Technology of China
2024
University Hospital Ulm
2023
Xuzhou Medical College
2023
Chinese Academy of Sciences
2016-2022
Shanghai Institute of Materia Medica
2022
Shandong University
2020-2021
Abstract Adhesion G protein-coupled receptors (aGPCRs) are essential for a variety of physiological processes such as immune responses, organ development, cellular communication, proliferation and homeostasis 1–7 . An intrinsic manner activation that involves tethered agonist in the N-terminal region receptor has been proposed aGPCRs 8,9 , but its molecular mechanism remains elusive. Here we report protein-bound structures ADGRD1 ADGRF1, which exhibit many unique features with regard to...
Abstract Somatostatin receptors (SSTRs) play versatile roles in inhibiting the secretion of multiple hormones such as growth hormone and thyroid-stimulating hormone, thus are considered targets for treating tumors. Despite great progress made therapeutic development against this diverse receptor family, drugs that target SSTRs still show limited efficacy with preferential binding affinity conspicuous side-effects. Here, we report five structures SSTR2 SSTR4 different states, including two...
DTX/CS–Rh–PFC nanoparticles are hydrolyzed by glutathione in tumor cells, releasing DTX and oxygen molecules, thus exhibit good anti-tumor ability.
The diffuse axonal damage in white matter and neuronal loss, along with excessive neuroinflammation, hinder long-term functional recovery after traumatic brain injury (TBI). MicroRNAs (miRs) are small noncoding RNAs that negatively regulate protein-coding target genes a posttranscriptional manner. Recent studies have shown loss of function the miR-15a/16-1 cluster reduced neurovascular improved ischemic stroke vascular dementia. However, role neurotrauma is poorly explored. Here, we report...
Introduction: Nitro-oleic acid (OA-NO 2 ) is an endogenous peroxisome proliferator-activated receptor-γ (PPARγ) ligand and can activate this receptor under both physiological pathological conditions. In study, we explore the role molecular mechanisms of OA-NO in maintaining blood-brain barrier (BBB) integrity enhancing neurovascular function during ischemic stroke, with a particular emphasis on activation PPARγ signaling pathways. Methods: EC-selective conditional knockout (EC-PPARγ cKO)...
Abstract Background Glioblastoma is a lethal neoplasm with few effective therapy options. As mainstay in the current treatment of glioma at present, chemotherapeutic agents usually show inadequate therapeutic efficiency due to their low blood brain barrier traversal and targeting, together tumor multidrug resistance. Novel strategies are thus urgently needed improve chemotherapy outcomes. Results Here, we report that nanomedicines developed by functionalizing neurotropic rabies virus-derived...
Molybdenum oxide (MoOx) nanosheets have drawn increasing attention for minimally invasive cancer treatments but still face great challenges, including complex modifications and the lack of efficient accumulation in tumor. In this work, a novel multifunctional degradable FA-BSA-PEG/MoOx nanosheet was fabricated (LA-PEG FA-BSA dual modified MoOx): synergistic effect PEG BSA endows with excellent stability compatibility; FA, targeting ligand, facilitates addition, DTX, model drug breast...
Introduction: Angiogenesis actively contributes to post-stroke functional recovery and improves long-term survival in stroke patients. Previously, we demonstrated that endothelium-targeted deletion of miR-15a/16-1 promotes angiogenesis by enhancing classic pro-angiogenic factors their receptors, genetic pericytes likewise stimulating cerebral angiogenesis. Here, further investigate the underlying mechanisms downstream targets pericytic after ischemic stroke. Methods: Pericyte-miR15a/16-1...
Ischemic stroke is a leading cause of disability and mortality worldwide. Recently, increasing evidence implicates microRNAs (miRs) in the pathophysiology ischemic stroke. Studies have shown that miR-15a/16-1 abnormally expressed brains after stroke, its upregulation may increase damage. Given sex age are significant modifiers outcomes, here we investigated whether inhibiting with antagomirs mitigates cerebral ischemia/reperfusion (I/R) injury sex- age-dependent manner. Young (3 months) aged...
It was previously report that the first open reading frame of Muscovy duck reocvirus S4 gene encodes a 95-amino-acid protein, designed p10.8, which has no sequence similarity to other known proteins. Its amino acid offers clues about its function. Subcellular localization and nuclear import signal p10.8 were characterized. We found protein localizes nucleus infected transfected cells, suggesting is not facilitated by viral infection or any protein. A functional non-canonical (NLS) for...
The expression of viral antigens in chronic hepatitis B virus (HBV) infection drives continuous liver inflammation, one the main risk factors to develop cancer. HBV developed immune-suppressive functions escape from host immune system, but their link tumor development is not well understood. Here, we analyzed if and how surface antigen (HBs) combined hepatocellular-cholangiocarcinoma (cHCC/iCCA) cells influences antigenicity for CD8 T cells. We randomly isolated tissues...
1. In recent years, the minipig is increasingly used as a test species in non-clinical assessment of drug candidates. While there good scientific evidence available concerning cytochrome P450-mediated metabolism minipig, knowledge other metabolic pathways more limited. 2. The aim this study was to provide an understanding when, why, and how differs from commonly studies. In-house cross-species metabolite profile comparisons hepatocytes microsomes 38 Roche development compounds were...
Abstract The ionospheric response to corotating interaction region (CIR)‐induced geomagnetic activity on 4 April 2005 has been studied using in situ electron density measurements, ground GPS‐total content (TEC) observations, and numerical simulations of the National Center for Atmospheric Research Thermosphere‐Ionosphere‐Electrodynamics General Circulation Model (TIE‐GCM). case study resulted that positive occurred from high low latitudes. effect at latitudes could continue days, whereas...
Abstract As more and protein biotherapeutics enter the drug discovery pipelines, there is an increasing interest in tools for mechanistic metabolism investigations of biologics order to identify prioritize most promising candidates. Understanding or even predicting vivo clearance support translational pharmacokinetic modeling activities essential, however a lack effective validated vitro cellular tools. Although different mechanisms have be adressed context disposition, scope not comparable...
Endometrial cancer (EC) is a malignant tumor. Natural killer (NK) cells play crucial role in various cancers, but their EC unclear. To this purpose, paper, differential expression analysis was performed on transcriptome data from the TCGA database, and obtained DEGs collected NRGs were intersected, single-factor Cox regression Lasso-Cox intersected genes to obtain prognosis-related risk model, respectively. These models validated by Kaplan-Meier (KM) survival curve ROC internal external test...