A5021886812- Microbial Metabolites in Food Biotechnology
- Plant biochemistry and biosynthesis
- Plant Gene Expression Analysis
- MicroRNA in disease regulation
- Organ Transplantation Techniques and Outcomes
- Acute Kidney Injury Research
- Nuclear Receptors and Signaling
- Microbial Metabolic Engineering and Bioproduction
- Bioinformatics and Genomic Networks
- Photosynthetic Processes and Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Neurological Disease Mechanisms and Treatments
- Flowering Plant Growth and Cultivation
- Circular RNAs in diseases
- Plant and animal studies
- Maternal and Perinatal Health Interventions
- Light effects on plants
- Single-cell and spatial transcriptomics
- Nitric Oxide and Endothelin Effects
- Apelin-related biomedical research
- Histone Deacetylase Inhibitors Research
- Trace Elements in Health
- Bacteriophages and microbial interactions
- Peroxisome Proliferator-Activated Receptors
- Maternal Mental Health During Pregnancy and Postpartum
University of Pittsburgh
2024-2025
Fujian Medical University
2021-2023
Gannan Medical University
2023
Fujian Provincial Hospital
2023
Beijing Academy of Agricultural and Forestry Sciences
2020-2021
Introduction: Nitro-oleic acid (OA-NO 2 ) is an endogenous peroxisome proliferator-activated receptor-γ (PPARγ) ligand and can activate this receptor under both physiological pathological conditions. In study, we explore the role molecular mechanisms of OA-NO in maintaining blood-brain barrier (BBB) integrity enhancing neurovascular function during ischemic stroke, with a particular emphasis on activation PPARγ signaling pathways. Methods: EC-selective conditional knockout (EC-PPARγ cKO)...
Spatial multi-modal omics technology, highlighted by Nature Methods as an advanced biological technique in 2023, plays a critical role resolving regulatory processes with spatial context. Recently, graph neural networks based on K-nearest neighbor (KNN) graphs have gained prominence methods due to their ability model semantic relations between sequencing spots. However, the fixed KNN fails capture latent hidden inevitable data perturbations during process, resulting loss of information. In...
Chrysanthemum morifolium is one of the most economically important and popular floricultural crops in family Asteraceae. flowers vary considerably terms colors shapes. However, molecular mechanism controlling development chrysanthemum floral shapes remains an enigma. We analyzed a cut-flower variety that produces normal capitula composed ray florets with normally developed pistils purple corollas mutant comprising green vegetative buds instead pistils.We conducted whole-transcriptome...
Spatial multi-modal omics technology, highlighted by Nature Methods as an advanced biological technique in 2023, plays a critical role resolving regulatory processes with spatial context. Recently, graph neural networks based on K-nearest neighbor (KNN) graphs have gained prominence methods due to their ability model semantic relations between sequencing spots. However, the fixed KNN fails capture latent hidden inevitable data perturbations during process, resulting loss of information. In...
Postpartum depression (PPD) is a severe psychiatric disorder that negatively affects postnatal mothers worldwide. The aim of the study to investigate association between postpartum pain sensitivity and PPD as well identify other potential risk factors for their interconnections. current was prospective observational clinical enrolled 210 singleton pregnant women in tertiary referral hospital from January December 2020. assessed by Mandarin Chinese version Pain Sensitivity Questionnaire...
Introduction: Angiogenesis actively contributes to post-stroke functional recovery and improves long-term survival in stroke patients. Previously, we demonstrated that endothelium-targeted deletion of miR-15a/16-1 promotes angiogenesis by enhancing classic pro-angiogenic factors their receptors, genetic pericytes likewise stimulating cerebral angiogenesis. Here, further investigate the underlying mechanisms downstream targets pericytic after ischemic stroke. Methods: Pericyte-miR15a/16-1...
Renal ischemia-reperfusion injury (IRI) is a disease with high incidence rate in kidney related surgery. Micro RNA (miRNA) and transcription factors (TFs) are widely involved the process of renal IRI through regulation their target genes. However, regulatory relationships functional roles TFs, miRNAs mRNAs progression insufficiently understood. The present study aimed to clarify underlying mechanism IRI.Six gene expression profiles were downloaded from Gene Expression Omnibus (GEO)....
Ischemic stroke is a leading cause of disability and mortality worldwide. Recently, increasing evidence implicates microRNAs (miRs) in the pathophysiology ischemic stroke. Studies have shown that miR-15a/16-1 abnormally expressed brains after stroke, its upregulation may increase damage. Given sex age are significant modifiers outcomes, here we investigated whether inhibiting with antagomirs mitigates cerebral ischemia/reperfusion (I/R) injury sex- age-dependent manner. Young (3 months) aged...
Abstract Background Chrysanthemum morifolium is one of the most economically important and popular floricultural crops in family Asteraceae. flowers vary considerably terms colors shapes. However, molecular mechanism controlling development chrysanthemum floral shapes remains an enigma. We analyzed a cut-flower variety that produces normal capitula composed ray florets with normally developed pistils purple corollas mutant comprising green vegetative buds instead pistils. Results conducted...
Single-cell multi-omics (scMulti-omics) refers to the paired multimodal data, such as Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-seq), where regulation each cell was measured from different modalities, i.e. genes proteins. scMulti-omics can reveal heterogeneity inside tumors understand distinct genetic properties diverse types, which is crucial targeted therapy. Currently, deep learning methods based on attention structures in bioinformatics area face two...
Abstract Background Postoperative nausea and vomiting (PONV) is the most common adverse reaction after surgery. A variety of methods have been used to prevent PONV, but this condition has still failed reach a satisfactory level. From perspective interaction between gut microbes host, 16S absolute quantitative sequencing technology find new ideas for prevention. Methods The patients suffering from 24 h surgery were divided into PONV group (n = 22) non-PONV 22). microorganisms related...
Abstract Background Chrysanthemum morifolium is one of the most economically important and popular floricultural crops in Asteraceae. Chrysanthemums have many different flower colors shapes. However, molecular mechanism controlling development chrysanthemum floral shapes still an enigma. We obtained a cut variety with mutant capitula which ray florets became green inside pistils vegetative buds, while normal rounds purple few disc florets. Results conducted whole-transcriptome analysis...
Abstract Background: Chrysanthemum morifolium is one of the most economically important and popular floricultural crops in family Asteraceae. flowers vary considerably terms colors shapes. However, molecular mechanism controlling development chrysanthemum floral shapes remains an enigma. We analyzed a cut-flower variety that produces normal capitula composed ray florets with normally developed pistils purple corollas mutant comprising green vegetative buds instead pistils. Results: conducted...