A5001679302- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Exercise and Physiological Responses
- Pharmacological Effects of Natural Compounds
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2020
Peking Union Medical College Hospital
2020
Abstract Chronic pruritus is a symptom that commonly observed in neurological diseases. It has been hypothesized the chronic may result from sensitization of itch-signaling pathways but mechanisms remain obscure. In this study, we established mouse model compression dorsal root ganglion (CCD) and injected various pruritogenic algogenic agents intradermally to calf skin ipsilateral compressed (DRG). Compared naïve mice, significant increase itch-related behaviors was CCD mice after injection...
Abstract Background : Chronic pruritus is a symptom that commonly observed in neurological diseases. It has been hypothesized the chronic may result from sensitization of itch-signaling pathways but mechanisms remain obscure. Methods: In this study, we established mouse model compression dorsal root ganglion (CCD) and injected various pruritogenic algogenic agents intradermally to calf skin ipsilateral compressed DRG. We additionally investigated if pruritogen-evoked activities (DRG) neurons...