A5101516600- Microbial Metabolic Engineering and Bioproduction
- Enzyme Catalysis and Immobilization
- Biofuel production and bioconversion
- Epigenetics and DNA Methylation
- Biochemical and Molecular Research
- CRISPR and Genetic Engineering
- Sirtuins and Resveratrol in Medicine
- Calcium signaling and nucleotide metabolism
- Histone Deacetylase Inhibitors Research
- MicroRNA in disease regulation
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Bacterial Genetics and Biotechnology
- Genomics and Chromatin Dynamics
- Cancer, Hypoxia, and Metabolism
- Topic Modeling
- Advanced Image and Video Retrieval Techniques
- Plant Gene Expression Analysis
- Sentiment Analysis and Opinion Mining
- RNA modifications and cancer
- Robotics and Sensor-Based Localization
- Renal cell carcinoma treatment
- Bacteriophages and microbial interactions
- Renal and related cancers
University of Science and Technology of China
2018-2024
Zhejiang University of Technology
2019-2024
Guangzhou University of Chinese Medicine
2022-2024
Peking University First Hospital
2014-2023
Peking University
2014-2023
Nanjing Normal University
2022-2023
Beijing University of Posts and Telecommunications
2023
Xinjiang Medical University
2023
Institute of Quality Standards and Testing Technology for Agro Products
2022
Xinjiang Academy of Agricultural Sciences
2022
MicroRNAs are endogenous small noncoding RNAs that functionally involved in numerous critical cellular processes including tumorigenesis. Data mining using a microRNA array database suggested let-7d may be associated with renal cell carcinoma (RCC) malignant progression. Here, we performed further analyses to determine whether is linked RCC malignancy. Quantitative real-time PCR was used the level of mature clinical specimens and its correlation clinicopathological data. Immunohistochemical...
Nicotinamide mononucleotide (NMN) has garnered substantial interest as a functional food product. Industrial NMN production relies on chemical methods, facing challenges in separation, purification, and regulatory complexities, leading to elevated prices. In contrast, biosynthesis through fermentation or enzyme catalysis offers notable benefits like eco-friendliness, recyclability, efficiency, positioning it primary avenue for future synthesis. Enzymatic synthesis encompasses the...
Enzymatic synthesis of β-nicotinamide mononucleotide (NMN) from D-ribose has garnered widespread attention due to its cheap material, the use mild reaction conditions, and ability produce highly pure products with desired optical properties. However, overall NMN yield this method is impeded by low activity rate-limiting enzymes. The ribose-phosphate diphosphokinase (PRS) nicotinamide phosphoribosyltransferase (NAMPT), that control rate reaction, were engineered improve efficacy. actives...
Plant heme oxygenases (HOs) regulate biosynthesis of phytochrome which accounts for photo-acceptance and -morphogenesis. Recent studies have demonstrated that plant HOs also many other physiological processes including response to environmental stimuli. To elucidate the mechanism by adaptation heavy metal exposure, three novel genes were isolated from rapeseed (Brassica napus) their expression patterns analysed. Alignment deduced protein sequences revealed BnHOs share high identity with...
Environmental pollution due to resistance genes from livestock manure has become a serious issue that needs be resolved. However, little studies focused on the removal of in simultaneous processing feces and urine. This study investigated fate antibiotic (ARGs), metal (MRGs), class 1 integron-integrase gene (intI1) during thermophilic fermentation swine an ectopic system (EFS), which been regarded as novel for efficiently treating both The abundances MRGs tetracycline were 34.44–97.71% lower...
Autophagy is a self-proteolytic process that degrades intracellular material to enable cellular survival under unfavorable conditions. However, how autophagy activated in human carcinogenesis remains largely unknown. Herein we report an epigenetic regulation of cancer cells. YY1 (YY1 transcription factor) well-known regulator and upregulated many cancers. We found knockdown inhibited cell viability flux through downregulating SQSTM1 (sequestosome 1). regulated expression the modulation...
Super enhancers are critical for the gene transcription responsible cell fate by interacting with factors. However, relevance of HSF1 to super in tumors remains obscure. We profiled H3K27ac enrichment chromatin immunoprecipitation sequencing. HSF1-mediated lncRNAs were identified lncRNA microarray. The characteristics LINC00857 explored vitro and vivo assays. mechanism was studied via immunoprecipitation, RNA HSF1/ANXA11 knockout mice. found that occupied multiple loci colorectal cancer....
Immune checkpoints inhibitors are effective but it needs more precise biomarkers for patient selection. We explored the biological significance of LINC00862 in pan-cancer by bioinformatics. And we studied its regulatory mechanisms using chromatin immunoprecipitation and RNA assays etc. TCGA single-cell sequencing data analysis indicated that was overexpressed majority tumor stromal cells, which related with poor prognosis. expression immune cell infiltration expression, had a high predictive...
Through silencing tumor suppressor genes, epigenetic changes can activate signaling pathways important to cancer development. In this report, we found an contribution the aberrant activation of wnt in human gastric cancer. CXXC4 (CXXC finger protein 4) was identified as a novel target EZH2 (enhancer zeste homolog 2), and promotes by downregulating expression. inhibits growth cells both vitro vivo through inactivating signaling. contrast, depletion activates anchorage-independent nontumor...
Sonic hedgehog (Shh) is involved in the induction of early cartilaginous differentiation mesenchymal cells limb. We investigated whether Shh could promote redifferentiation dedifferentiated chondrocytes and have a favorable effect on regeneration cartilage. Articular rats were separated cultured. The transfected with was evaluated using monolayer pellet culture system. signaling molecules (Ptc 1, Gli 1 Sox9) pathway investigated. A rat model articular cartilage defect used to evaluate repair...
Enterobacter aerogenes is a facultative anaerobe and one of the most widely studied bacterial strains because its ability to use variety substrates, produce hydrogen at high rate, growth rate during dark fermentation. However, production has not been optimized. In this present study, three strategies improve in E. aerogenes, namely disruption nuoCDE, overexpression small RNA RyhB NadE regulate global anaerobic metabolism, redistribution metabolic flux. The goal study was clarify effect RyhB,...
To carry out autonomous 3D scanning and online reconstruction of unknown indoor scenes, one has to find a balance between global exploration the entire scene local objects within it. In this work, we propose novel approach, which provides object-aware guidance for autoscanning, exploring, reconstructing, understanding an navigation pass. Our approach interleaves object analysis identify next best (NBO) exploration, information gain plan view (NBV) scanning. First, objectness-based...
Doxorubicin induces DNA damage to exert its anti‐cancer function. Histone deacetylase 1 (HDAC1) can protect the genome from damage. We found that doxorubicin specifically downregulates HDAC1 protein expression and identified as a target of miR‐520h, which was upregulated by doxorubicin. Doxorubicin‐induced cell death impaired exogenous or miR‐520h inhibitor. Moreover, reduced level γH2AX preventing interaction with DNA. In summary, expression, inducing HDAC1‐targeting exacerbate...