A5102838203- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Esophageal Cancer Research and Treatment
- Cancer-related gene regulation
- Cancer Risks and Factors
- Metabolism, Diabetes, and Cancer
- Osteomyelitis and Bone Disorders Research
- Epigenetics and DNA Methylation
- Bone health and treatments
- RNA modifications and cancer
- Bone and Joint Diseases
- Proteoglycans and glycosaminoglycans research
- Pancreatic and Hepatic Oncology Research
- Alkaline Phosphatase Research Studies
- Growth Hormone and Insulin-like Growth Factors
- Circular RNAs in diseases
- Prostate Cancer Diagnosis and Treatment
- Advanced Chemical Sensor Technologies
- Nerve injury and regeneration
- Atherosclerosis and Cardiovascular Diseases
- Phytoestrogen effects and research
- Viral-associated cancers and disorders
- Protein Tyrosine Phosphatases
- Connective tissue disorders research
- Kruppel-like factors research
Liaoning Technical University
2025
Gansu University of Traditional Chinese Medicine
2025
Chengdu University of Traditional Chinese Medicine
2024
Zhejiang University
2007-2022
Sir Run Run Shaw Hospital
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Inner Mongolia Yili Industrial Group (China)
2021
Second Affiliated Hospital of Shantou University Medical College
2020
Shantou University
2020
Harbin Medical University
2020
Abstract This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma (ESCC), which if diagnosed at advanced stages has <30% five-year survival rate. Comparing genome-wide methylation sites of 91 ESCC matched adjacent normal tissues, we identified 35,577 differentially methylated CpG (DMCs) characterized their distribution patterns. Integrating whole-genome RNA-sequencing data the same samples, found multiple...
Through silencing tumor suppressor genes, epigenetic changes can activate signaling pathways important to cancer development. In this report, we found an contribution the aberrant activation of wnt in human gastric cancer. CXXC4 (CXXC finger protein 4) was identified as a novel target EZH2 (enhancer zeste homolog 2), and promotes by downregulating expression. inhibits growth cells both vitro vivo through inactivating signaling. contrast, depletion activates anchorage-independent nontumor...
Abstract Altered expression of insulin‐like growth factor binding protein 7 (IGFBP7) has been found in colon cancer, but the exact regulatory mechanism not fully investigated. In order to elucidate mechanisms underlying aberrant IGFBP7 we used bisulphite sequencing PCR (BSP) detect detailed methylation profiles 5′ CpG island. Exon 1 gene was highly methylated IGFBP7‐negative cell lines unmethylated IGFBP7‐positive lines. The status promoter region and intron so discriminating ‐negative...
Previous data suggest that myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells. The relationships between serum myostatin, body composition lipids bone mineral density in postmenopausal women remain unclear. aim this study is to elucidate composition, central south Chinese women.A cross-sectional was conducted 175 healthy women, aged 51-75 years old. Bone (BMD) were measured by double energy X-ray absorptiometry (DXA). Serum 25-dihydroxyvitamin...
The study was carried out to reconstruct a prostatic acinus-like structure from epithelial cells in new culture system which can provide more physiological condition than conventional cell methods.Prostatic were isolated ventral and dorsolateral prostates of the rat separately cultured three-dimensional collagen gel matrix. observed by photo-microscopy transmission electron microscopy. Differentiation proliferation examined immunohistochemistry using PAP PSA kits bromodeoxy-uridine (BrdU)...
To determine the role of Midkine (MDK) in non-invasive detection bladder cancer (Bca) and relationship with Ki67.Sixty-five Bca patients 55 non-Bca or healthy volunteers were enrolled voided urine samples prospectively obtained on first day enrollment. Tissue collected by surgery. MDK Ki67 expressions analyzed immunohistochemistry Western Blot (WB). Specificity sensitivity mRNA testing determined Receiver Operating Characteristic curve (ROC). The between was also assessed.MDK overexpressed...
γ-aminobutyric acid (GABA) is a naturally occurring non-protein amino in the nervous system and has wide range of physiological functions body. Walnut peptide (WP) contains high levels arginine, aspartic acid, glutamate, been shown to improve cognitive deficits memory impairment mice, while restoring antioxidant enzyme reducing brain inflammatory mediators.This study investigated effects GABA WP, either alone or combination, on sleep disturbances mice. The pentobarbital-prolonged test,...
<title>Abstract</title> Background: Osteonecrosis of the femoral head (ONFH) is a severe complication systemic lupus erythematosus (SLE). Although there characteristic disease spectrum between SLE and ONFH, exact pathogenesis remains unclear. Furthermore, lack early diagnostic criteria complicates diagnosis SLE-ONFH. This study aimed to identify key candidate genes in patients with ONFH. Methods: ONFH datasets were obtained from Gene Expression Omnibus (GEO). Differentially expressed (DEGs)...
Objective: To explore the effects of circTNPO1 on proliferation and metastasis osteosarcoma (OS) by sponging miR-338-3p. Methods: The expression osteoblasts multiple OS cell lines were detected qRT-PCR. CircTNPO1 stable knockdown 143B line was constructed sh-circTNPO1. Cell count kit 8 (CCK-8) assay wound healing applied to evaluate this cell. Luciferase reporter used binding between In xenograft tumor model, miR-338-3p inhibitor or its control injected into tumors. weight size tumors...
To isolate the collagen phagocytic subpopulation of fibroblast (CPSF) and non-collagen (nCPSF) to identify their differentially expressed genes. The CPSF nCPSF was isolated by using collagen-fluorescein-isothiocynate-latex bead (COL-FITC-LB) phagocytosis technique FCM sorting method. Microarray analysis used screen genes, which were verified real-time PCR. successfully isolated. Seventeen genes identified. Compared with nCPSF, expression 12 or 5 up-regulated down-regulated in CPSF. Three...
Objective To observe the changes in bone mineral density and microstructure parameters sclerostin (SOST) gene knockout mice treated with glucocorticoid. Methods 12 4-week-old SOST were randomly divided into two groups (n=6): methylprednisolone intervention group [SOM group, 3 mg/(kg·d), subcutaneous injection], placebo (SOS isovolumetric saline injection). 12 wild-type (WTS injection), wild [WTM injection]. weeks later, sacrificed one lumbar vertebra of each mouse was selected for...