A5102798489- Antimicrobial Peptides and Activities
- Organophosphorus compounds synthesis
- Sulfur-Based Synthesis Techniques
- Synthesis of Indole Derivatives
- Catalytic C–H Functionalization Methods
- Insect and Arachnid Ecology and Behavior
- Analytical Chemistry and Chromatography
- Fluorine in Organic Chemistry
- Radical Photochemical Reactions
- Nanoplatforms for cancer theranostics
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Chemical synthesis and alkaloids
- Bacterial biofilms and quorum sensing
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Probiotics and Fermented Foods
- Synthesis and pharmacology of benzodiazepine derivatives
- RNA Interference and Gene Delivery
- Pneumocystis jirovecii pneumonia detection and treatment
- Insect and Pesticide Research
- Catalytic Alkyne Reactions
- Bacterial Genetics and Biotechnology
- Lipid Membrane Structure and Behavior
- Immune Response and Inflammation
Zhejiang Gongshang University
2021
Lanzhou University
2006-2021
Zhengzhou University
2019
Lanzhou City University
2017
A Michael-aldol reaction of 2-mercaptobenzaldehyde with β-indole-β-CF3 enones catalyzed by a squaramide has been realized. The method affords series 2-CF3-2-indole-substituted thiochromanes featuring CF3-containing quaternary stereocenter in excellent yields, diastereoselectivities, and enantioselectivities.
This method provides a visible-light-induced radical tandem cyclization for the synthesis of phosphorus phenanthridines with various nitrogen-containing substrates.
The misuse and overuse of antibiotics result in the emergence resistant bacteria fungi, which make an urgent need new antimicrobial agents. Nowadays, peptides have attracted great attention researchers. However, low physiological stability biological system limits application naturally occurring as novel therapeutics. In present study, we synthesized derivatives protonectin by substituting all amino acid residues or cationic lysine residue with corresponding D-amino acids. Both D-enantiomer...
The incidence of life‐threatening invasive fungal infections increased significantly in recent years. However, the antifungal therapeutic options are very limited. Antimicrobial peptides a class potential lead chemical for development novel agents. peptide polybia‐CP was purified from venom social wasp Polybia paulista . In this study, we synthesized and determined its effects against series Candidian species. Our results showed that has potent activity fungicidal tested cells with proposed...
Base-mediated stereospecific tandem reactions using para-quinone methides and carbene-like benzyl chlorides are developed. DBU-mediated 1,6-addition/cyclization/isomerization produce triarylsubstituted alkenes in 43–89% yields Z/E ratios of 5:1 to 35:1 favor the Z-isomers. Single-step 1,6-conjugate additions realized with mediation cesium carbonate, different triaryl chloroethanes obtained 41–54% excellent diastereoselectivities more than 20:1. In addition, 1,6-addition/cyclization achieved...
A theoretical investigation was carried out on the retention and separation of enantiomeric molecules including nonsteroidal anti-inflammatory drugs, anti-neoplastic compounds N-derivatized amino acids by capillary electrophoresis using macrocyclic antibiotics, a new class chiral selectors, as stationary phase. Firstly docking methods were used to study enantiorecognition in electrophoresis. The molecular dynamics simulations two diastereoisomer complexes then performed order understand how...
A one-pot synthesis of N -phosphorylated amides was achieved by a three-component reaction with carboxylic acids, phosphorus chlorides and azides under mild conditions.
Open AccessCCS ChemistryRESEARCH ARTICLE1 Apr 2022New Staudinger Strategy Enabled N-Acyl Phosphinamidites Synthesis Yuan-Yuan Zhu, Gang-Wei Wang, Jin Yang and Shang-Dong Zhu State Key Laboratory of Applied Organic Chemistry, Lanzhou University, 730000 , Wang *Corresponding author: E-mail Address: [email protected] for Oxo Selective Oxidation, Institute Chemical Physics, Chinese Academy Sciences, https://doi.org/10.31635/ccschem.021.202100902 SectionsSupplemental MaterialAboutAbstractPDF...