A5083183865- Frailty in Older Adults
- Nutrition and Health in Aging
- Health Systems, Economic Evaluations, Quality of Life
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Chronic Disease Management Strategies
- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Hip and Femur Fractures
- Diet and metabolism studies
- Global Health Care Issues
- Balance, Gait, and Falls Prevention
- Resilience and Mental Health
- Alzheimer's disease research and treatments
- Botulinum Toxin and Related Neurological Disorders
- Bone health and osteoporosis research
- Folate and B Vitamins Research
- COVID-19 Clinical Research Studies
- Streptococcal Infections and Treatments
- Metabolism and Genetic Disorders
- Nuclear Receptors and Signaling
- Vitamin D Research Studies
- Single-cell and spatial transcriptomics
- Aging and Gerontology Research
- Sleep and related disorders
Capital Medical University
2016-2025
National Clinical Research Center for Digestive Diseases
2019-2025
National Clinical Research
2020-2024
Mountain Medicine Society of Nepal
2024
Beijing Geriatric Hospital
2017-2021
Centre Hospitalier Universitaire de Toulouse
2017-2018
Hôpital Purpan
2017-2018
Université Toulouse III - Paul Sabatier
2018
Institut de Mathématiques de Toulouse
2017
Objectives: The World Health Organization (WHO) proposed the Integrated Care for Older People (ICOPE) screening tool to identify older people with priority conditions associated declines in intrinsic capacity (IC). We aimed determine clinical utility of WHO ICOPE a Chinese population. Method: A total 376 adults aged 68.65 ± 11.41 years participated study. IC was assessed tool, covering five domains: cognitive, locomotor, sensory, vision, and psychological capacity. activities daily living...
Objectives Intrinsic capacity (IC) was proposed by the WHO as a new concept for capturing an individual’s functional capacities across their lifetime. We aimed to investigate prevalence and factors associated with IC decline examine associations between adverse outcomes among community-dwelling older adults in China. Design A cross-sectional study. Setting Community, Participants Data were derived from China Comprehensive Geriatric Assessment Study, population-based nationally representative...
Objective: This study aimed to assess the status of intrinsic capacity (IC)-a novel function-centered construct proposed by WHO and examine whether impairment in IC predicts subsequent 1-year activities daily living (ADL) disability better than a disease-based approach, i. e., multimorbidity status. Methods: included data community-dwelling older adults from Beijing Longitudinal Study on Aging II aged 65 years or who were followed up at 1 year. Multivariate logistic regressions performed...
The traditional disease-oriented model of healthcare is inadequate to address the needs older population. Greater attention should be given strategies that promote healthy aging. Recently proposed constructs intrinsic capacity (IC) and physical resilience (PR) hold great potential reshape geriatric medicine aging research. These accentuate positive health attributes people in contrast popular frailty construct centered on functional deficits. IC was introduced by World Health Organization...
China and the world are facing severe population aging an increasing burden of age-related diseases. Aging brain causes major diseases, such as neurodegenerative diseases stroke. Identifying biomarkers for effective assessment establishing a system could facilitate development intervention strategies prevention treatment aging-related Thus, experts from Biomarker Consortium (ABC) have combined latest research results practical experience to recommend form expert consensus, aiming provide...
Abstract Background Fragmentation of services increases health and social care burden as people live longer with higher prevalence diseases, frailty dependency. Local evidence for implementing person-centred integrated is urgently needed to advance practice policies achieve healthy ageing. Objective To test the feasibility impact World Health Organization's (WHO) Integrated Care Older People (ICOPE) approach in China. Design A randomised controlled trial examining ICOPE approach, evaluating...
Various factors including cardio-metabolic disorders are found to be correlated with frailty. With the increase in age, older adults likely have elevated blood glucose level. In this study we intend investigate prevalence and incidence of frailty pre-diabetic diabetic community dwelling elderly population associated risk factors.At baseline total 10,039 subjects a mean age 70.51 (±7.82) were included. A 6,293 followed up at 12 months. Frailty index (FI) 32 items was developed using...
Findings from recent Alzheimer’s disease prevention trials have shown subjects with increased dementia score based upon mid-life cardiovascular risk factors, to benefit multi-domain intervention strategies some extent. The effects of such interventions on cognitive functions remains yet be well-established. This study is a secondary analysis the MAPT study, 1,293 older (mean age 75 years) high CAIDE (i.e., ≥6) were classified according four groups: 1) plus placebo, 2) isolated...
Objectives: To evaluate and compare the efficacy of National Early Warning Score, Score 2, Rapid Emergency Medicine Confusion, Respiratory rate, Blood pressure, Age 65 score, quick Sepsis-related Organ Failure Assessment on predicting in-hospital death in patients with coronavirus disease 2019. Design: A retrospective, observational study. Setting: Single center, West Campus Wuhan Union hospital-a temporary center to manage critically ill Patients: total 673 consecutive adult 2019 between...
Gait disturbance is an important risk factor for falls in Parkinson's disease (PD). Using wearable sensors, we can obtain the spatiotemporal parameters of gait and calculate variability. This prospective study aims to objectively evaluate characteristics PD fallers, further explore relationship between gait, variability patients followed six months.Fifty-one were enrolled this study. A seven-meter timed up go test was performed. determined by a analysis system. Patients monthly telephone...
To determine the association between plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) and intrinsic capacity in an older population.
Objectives: Hypertension is highly prevalent in the elderly and represents a major risk factor for cardiovascular complications such as coronary heart disease, stroke, cognitive dysfunction. Frailty common geriatric syndrome characterized by increased of disability, hospitalization, mortality. However, little known about frailty status older adults with hypertension. Thus, we aimed to explore epidemiological characteristics related factors Chinese Methods: The current study included data...
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. Ageing considered to be greatest risk factor for PD, with a complex interplay between genetics and environment. With population ageing, prevalence of PD expected escalate worldwide; thus, it utmost importance reduce burden PD. To date, there are no therapies cure disease, current treatment strategies focus on management symptoms. Older adults often have multiple chronic diseases geriatric...
Abstract Background Intrinsic capacity is the combination of individual physical and mental abilities, reflecting aging degree older adults. However, mechanisms metabolic characteristics decline in intrinsic are still unclear. Aims To identify signatures associated pathways based on metabolite features. Methods We recruited 70 participants aged 77.19 ± 8.31 years. The five domains were assessed by Short Physical Performance Battery (for mobility), Montreal cognition assessment cognition),...
Objective: To probe the spatiotemporal patterns of incidence scarlet fever in Beijing, China, from 2005 to 2014. Methods: A analysis was conducted at district/county level Beijing region based on reported cases during study period. Moran’s autocorrelation coefficient used examine spatial fever, whereas Getis-Ord Gi* statistic determine hotspot fever. Likewise, space-time scan detect clusters, including relative risk across all settings. Results: total 26,860 were period (2005–2014). The...
Background: Frailty is known to be highly prevalent in older hemodialysis (HD) patients.We studied the prevalence of frailty and its associated factors Chinese HD further if could predict survival patients.Methods: This a prospective study involving patients receiving maintenance dialysis center Xuanwu Hospital, Beijing.Study subjects were enrolled from October December, 2017 followed up for two years.Demographic data, comorbidities biological parameters collected.Frailty was assessed using...