A5101740858- Frailty in Older Adults
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Nutrition and Health in Aging
- COVID-19 Clinical Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Neuroimaging Techniques and Applications
- Cellular transport and secretion
- Cardiac, Anesthesia and Surgical Outcomes
- Acupuncture Treatment Research Studies
- Nerve injury and regeneration
- Healthcare Systems and Public Health
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Chromatography in Natural Products
- Biotin and Related Studies
- Genomic variations and chromosomal abnormalities
- Epigenetics and DNA Methylation
- Advanced Proteomics Techniques and Applications
- Single-cell and spatial transcriptomics
- Diabetes Management and Research
- Prion Diseases and Protein Misfolding
- Adipose Tissue and Metabolism
- EEG and Brain-Computer Interfaces
- Genetics, Aging, and Longevity in Model Organisms
Capital Medical University
2006-2024
National Clinical Research Center for Digestive Diseases
2021-2024
Chinese Institute for Brain Research
2022
Beijing Geriatric Hospital
2020-2021
Park University
2017-2018
Faculty of Media
2017
Hanover College
2017
Xuan Wu Hospital of the Capital Medical University
2012
Objectives: The World Health Organization (WHO) proposed the Integrated Care for Older People (ICOPE) screening tool to identify older people with priority conditions associated declines in intrinsic capacity (IC). We aimed determine clinical utility of WHO ICOPE a Chinese population. Method: A total 376 adults aged 68.65 ± 11.41 years participated study. IC was assessed tool, covering five domains: cognitive, locomotor, sensory, vision, and psychological capacity. activities daily living...
The traditional disease-oriented model of healthcare is inadequate to address the needs older population. Greater attention should be given strategies that promote healthy aging. Recently proposed constructs intrinsic capacity (IC) and physical resilience (PR) hold great potential reshape geriatric medicine aging research. These accentuate positive health attributes people in contrast popular frailty construct centered on functional deficits. IC was introduced by World Health Organization...
Objectives: To evaluate and compare the efficacy of National Early Warning Score, Score 2, Rapid Emergency Medicine Confusion, Respiratory rate, Blood pressure, Age 65 score, quick Sepsis-related Organ Failure Assessment on predicting in-hospital death in patients with coronavirus disease 2019. Design: A retrospective, observational study. Setting: Single center, West Campus Wuhan Union hospital-a temporary center to manage critically ill Patients: total 673 consecutive adult 2019 between...
<i>Background:</i> Biomarkers for neurodegenerative diseases are essential to facilitate disease diagnosis. Application of proteomics has greatly hastened the search novel biomarkers. In this study, new potential biomarkers were discovered, and a diagnostic pattern was established idiopathic Parkinson’s (PD) by using proteomic technology. <i>Methods:</i> Serum proteins from PD patients controls captured magnetic bead-based weak cation exchange. The molecular weight in...
Our previous research showed that octacosanol exerted its protective effects in 6-hydroxydopamine-induced Parkinsonian rats. The goal of this study was to investigate whether would attenuate neurotoxicity 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP)-treated C57BL/6N mice and potential mechanism. Behavioral tests, tyrosine hydroxylase immunohistochemistry western blot were used the a mouse model Parkinson's disease. Oral administration (100 mg/kg) significantly improved behavioral...
Frailty is one of the most important risk factors for adverse outcomes in older adults. Despite a high prevalence, there still lack frailty screening instruments specific to Chinese We developed simple questionnaire (FSQ) that could predict long-term mortality. aimed explore reliability and construct validity this new measurement tool.A total 205 individuals aged 65 years or were recruited study. The FSQ phenotype assessed. included self-reported slowness, weakness, weight loss, inactivity,...
Objective To determine whether the brain-derived neurotrophic factor ( BDNF ) Val66Met polymorphism is associated with cognitive impairment (CI) in community-dwelling Chinese older adults, and to investigate this relationship modified by Apolipoprotein E APOE ɛ4 allele. Methods The study a secondary analysis of 703 participants aged ≥60 years randomly enrolled from Beijing Longitudinal Study Aging II prospective cohort. education-adjusted Mini-Mental State Examination Clinical Dementia...
Abstract Background With the extended life expectancy of Chinese population and improvements in surgery anesthesia techniques, number aged patients undergoing has been increasing annually. However, safety, effectiveness, quality are facing major challenges. In order to standardize perioperative assessment procedures, we have developed a evaluation auxiliary decision-making system named “Aged Patient Perioperative Longitudinal Evaluation–Multidisciplinary Trial (APPLE-MDT)”. Methods We will...
Abstract Background Heterozygous mutations in the glucocerebrosidase gene ( GBA ) have been shown to be an important genetic risk factor for Parkinson's disease (PD) worldwide. However, penetrance of heterozygote L444P, common mutation Asian population, is not known older Chinese people. Objectives To assess conversion rate PD identified carriers L444P/R community‐dwelling adults. Methods The was sequenced at position 444 8405 people than 55 years who participated Beijing Longitudinal Study...
The prevalence of postural tremor increases with age and the has been found to be associated aging-related physiological decline. However, whether in older adults is adverse outcomes such as disability unclear. This study investigated association between risk activities daily living (ADL) among community-dwelling people.Data were derived from a population-based Chinese aged ≥55 years. Postural was assessed at baseline using two-step method (i.e., screening followed by examination positive...
Subjective cognitive decline (SCD), an at-risk condition of Alzheimer's disease (AD), can involve various domains, such as memory, language, planning, and attention. We aim to explore the difference in amyloid load between single memory domain SCD (sd-SCD) multidomain (md-SCD) assess relationship pathology with quantitative scores objective cognition. A total 63 participants from SILCODE study underwent clinical evaluation, neuropsychological assessment, 18F-florbetapir PET scan. Global...
Parkinson's disease (PD) is characterized by excessively synchronized neural activity. In this paper, we recorded electrophysiological signals in Cortex of normal and PD mode monkey using homemade implantable microelectrode arrays (MEA), analyzed the characteristics action potentials (APs) local field (LFPs). Results showed that, comparing to monkey, spike-firing activity could be divided into two stages: continuous stage burst stage. The lasted for about 20s oscillated at low frequency...
Background: WHO recently characterized Coronavirus disease 2019 (COVID-19) as a pandemic. We aimed to evaluate and compare the efficacy of National Early Warning Score (NEWS), Rapid Emergency Medicine (REMS), quickSOFA (qSOFA) CRB65 on predicting bad outcome in patients with COVID-19.Methods: In this single-centered, retrospective, observational study, we enrolled 114 adult COVID-19 who were admitted west campus Wuhan Union hospital between Jan 30, 2020 Feb 24, 2020. The primary endpoint was...
To explore the roles of striatal subdivisions in pathogenesis frontotemporal dementia with parkinsonism (FTDP) a patient resulting from prion protein gene (PRNP) mutation. This received clinical interviews and underwent neuropsychological assessments, genetic testing, [18F]-fluorodeoxyglucose positron emission tomography ([18F]-FDG PET)/MRI, [18F]-dihydrotetrabenazine ([18F]-DTBZ PET)/CT. Region-of-interest analysis was conducted concerning metabolism, dopamine transport function between...