A5101708358- Animal Virus Infections Studies
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Herpesvirus Infections and Treatments
- Viral Infections and Immunology Research
- Genomics and Phylogenetic Studies
- Microbial infections and disease research
- Viral Infectious Diseases and Gene Expression in Insects
- Cytomegalovirus and herpesvirus research
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- interferon and immune responses
- Mycotoxins in Agriculture and Food
- SARS-CoV-2 and COVID-19 Research
- Plant Pathogens and Fungal Diseases
- Aquaculture disease management and microbiota
- Bacteriophages and microbial interactions
- Mosquito-borne diseases and control
- Hepatitis B Virus Studies
- Antibiotic Resistance in Bacteria
- Escherichia coli research studies
- Respiratory viral infections research
- Plant Virus Research Studies
- Virology and Viral Diseases
- Biochemical and Molecular Research
Henan Agricultural University
2015-2025
China Agricultural University
2024
Zhongda Hospital Southeast University
2023
Shihezi University
2016-2019
Novartis (United States)
2011-2017
Second Hospital of Nanchang
2015
Anhui University of Science and Technology
2014
Anhui Science and Technology University
2014
Army Medical University
2009-2013
Newcastle University
1994
Since May 2015, severe outbreaks of hepatitis-hydropericardium syndrome (HHS) associated with infections fowl aviadenovirus (FAdV) have emerged in broiler chickens several Chinese provinces. To identify the genotype and gain a better understanding genetic properties FAdV strains responsible for recent HHS China, complete genome sequences five isolates from provinces were determined. The results demonstrated that novel 4 (FAdV-4) was epidemic China. investigate molecular characteristics these...
Fusarium crown rot (FCR) is a severe and chronic disease in common wheat able to cause serious yield loss health problems human livestock.Here, 234 Chinese cultivars were evaluated four greenhouse experiments for FCR resistance genome-wide association studies (GWAS) performed using the 660 K genotyping assay. The results indicated that most showed index (DI) of 40-60, while some stably good (DI < 30). GWAS identified 286 SNPs be significantly associated with resistance, which 266, 6 8...
Macroautophagy/autophagy is a cellular degradation and recycling process that maintains the homeostasis of organisms. The protein role autophagy has been widely used to control viral infection at multiple levels. In ongoing evolutionary arms race, viruses have developed various ways hijack subvert in favor its replication. It still unclear exactly how affects or inhibits viruses. this study, we found novel host restriction factor, HNRNPA1, could inhibit PEDV replication by degrading...
Since May 2015, outbreaks of hydropericardium-hepatitis syndrome (HHS) caused by fowl adenovirus 4 (FAdV-4) with a novel genotype have been reported in China, causing significant economic losses to the poultry industry. A previous comparative analysis revealed that highly virulent FAdV-4 isolates contain various genomic deletions and multiple distinct mutations major structural genes fiber2 hexon. To identify responsible for virulence HHS-associated isolates, infectious clones were...
Fusarium crown rot (FCR) is one of the most serious diseases in wheat and causes yield loss health problems (Nellist et al., 2019). Lignin plant tissue exerts a variety functions such as antimicrobial, antiviral, antioxidant anti-cytotoxic (Ralph 2006). Research indicates that dirigent (DIR) proteins are involved synthesis lignin play important roles defence responses (Hosmani 2013; Ralph Wang Fristensky (2001) found DIR protein enhanced resistance to pathogens Rhizoctonia solani...
Porcine epidemic diarrhea has re-emerged with devastating impact in central China since October 2010. To investigate and analyze the reason of this outbreak, M ORF3 genes 15 porcine viruses (PEDV), which were collected from different areas during 2010 December 2011, amplified by reverse transcriptase polymerase chain reaction, cloned, sequenced, analyzed. Sequence analyses showed that nucleotides amino acids changed at some sites PEDV strains compared those CV777 reference strain. Based on...
Shigellosis in chickens was first reported 2004. This study aimed to determine the pathogenicity of Shigella and possibility cross-infection between humans chickens. The examined via infection three-day-old SPF with strain ZD02 isolated from a human patient. virulence invasiveness were by chicken intestines primary intestinal epithelial cells. results showed can cause death intraperitoneal injection chickens, but only induce depression crop injection. Immunohistochemistry transmission...
Testing P. aeruginosa efflux pump mutants showed that the LpxC inhibitor CHIR-090 is a substrate for MexAB-OprM, MexCD-OprJ, and MexEF-OprN. Utilizing PAO1 with chromosomal mexC::luxCDABE fusion, luminescent arose on medium containing 4 μg/ml CHIR-090, indicating upregulation of MexCD-OprJ. These were less susceptible to (MIC, μg/ml) had mutations in mexCD-oprJ repressor gene nfxB. Nonluminescent mexAB-oprM regulator mexR also observed. Plating clinical isolate K2153 selected alterations...
Over the past several decades, frequency of antibacterial resistance in hospitals, including multidrug (MDR) and its association with serious infectious diseases, has increased at alarming rates. Pseudomonas aeruginosa is a leading cause nosocomial infections, to virtually all approved agents emerging this pathogen. To address need for new treat MDR P. aeruginosa, we focused on inhibiting first committed step biosynthesis lipid A, deacetylation...
During asexual reproduction the embryogenic callus can differentiate into a new plantlet, offering great potential for fostering in vitro culture efficiency plants. The immature embryos (IMEs) of wheat (Triticum aestivum L.) are more easily able to generate than mature (MEs). To understand molecular process formation wheat, de novo transcriptome sequencing was used sequences from calli derived IMEs and MEs after 3d, 6d, or 15d (DC). In total, 155 million high quality paired-end reads were...
Porcine epidemic diarrhea virus (PEDV), an enteropathogenic coronavirus, has catastrophic impacts on the global pig industry. However, there remain no effective drugs against PEDV infection. In this study, we utilized a recombinant expressing renilla luciferase (PEDV-Rluc) to screen potential anti-PEDV agents from FDA-approved drug library in Vero cells. Four compounds were identified that significantly decreased activity of PEDV-Rluc. Among them, niclosamide was further characterized...
Fusarium crown rot (FCR) is a serious underlying disease to threaten wheat yield and quality recently. Here, we identify catalase antioxidant enzyme (TaCAT2) through genome wide association study (GWAS) whole-exome sequencing (WES) in two nested bi-parental populations. We verify the function of TaCAT2 regulating FCR resistance by genetic transformation. Moreover, screen sucrose non-fermenting-1-related protein kinase alpha subunit (TaSnRK1α) interacting with TaCAT2, subsequently find that...
Pseudorabies (PR) is a significant disease that adversely affects the healthy growth of pig industry in China. However, data on molecular epidemiology and genetic characterization PRV sparse. This study examined epidemic trends variation characteristics PR virus (PRV) Henan Province Six hundred eighty-eight clinically infected tissue samples were collected from 18 cities January 2021 to March 2023 tested for PRV. The was isolated positive identified by polymerase chain reaction...
The highly virulent porcine epidemic diarrhea virus (PEDV) emerged in 2010, and causes high mortality rates newborn pigs. There are no effective safe vaccines against the PEDV.
Interferon regulatory factor 1 (IRF1), as an important transcription factor, is abundantly induced upon virus infections and participates in host antiviral immune responses. However, the roles of porcine IRF1 (poIRF1) defense remain poorly understood. In this study, we determined that poIRF1 was upregulated infection with viruses distributed nucleus PK-15 cells. Subsequently, tested activities against several swine Overexpression can efficiently suppress replication viruses, knockdown...