A5100774208- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Occupational and environmental lung diseases
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Medical Imaging and Pathology Studies
- MicroRNA in disease regulation
- RNA modifications and cancer
- Pleural and Pulmonary Diseases
- Cancer Mechanisms and Therapy
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Peptidase Inhibition and Analysis
- Hepatitis C virus research
- Protease and Inhibitor Mechanisms
- Phosphodiesterase function and regulation
- Transplantation: Methods and Outcomes
- Zebrafish Biomedical Research Applications
- Frailty in Older Adults
- Pulmonary Hypertension Research and Treatments
- Autophagy in Disease and Therapy
- Cardiac Fibrosis and Remodeling
- S100 Proteins and Annexins
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Angiogenesis and VEGF in Cancer
- Cancer-related gene regulation
- Extracellular vesicles in disease
University of Oulu
2024
Zhejiang Cancer Hospital
2024
Nanjing Medical University
2007-2023
Jiangsu Province Hospital
2010-2023
Nanjing University of Chinese Medicine
2021-2023
Wenzhou Medical University
2023
First Affiliated Hospital of Wenzhou Medical University
2023
Hainan Medical University
2023
The University of Texas at Austin
2023
Guilin Medical University
2023
Abstract Background Silicosis is one of the most common occupational pulmonary fibrosis caused by respirable silica-based particle exposure, with no ideal drugs at present. Metformin, a commonly used biguanide antidiabetic agent, could activate AMP-activated protein kinase (AMPK) to exert its pharmacological action. Therefore, we sought investigate role metformin in silica-induced lung fibrosis. Methods The anti-fibrotic was assessed 50 mg/kg model. Silicon dioxide (SiO 2 )-stimulated...
N6-methyladenosine (m6A) is the most common and abundant internal modification of RNA. Its critical functions in multiple physiological pathological processes have been reported. However, role m6A silica-induced pulmonary fibrosis has not fully elucidated. AlkB homolog 5 (ALKBH5), a well-known demethylase, upregulated mouse model. Here, we sought to investigate function ALKBH5 triggered by silica inhalation.We performed studies with fibroblast cell lines models. The expression ALKBH5,...
Silicosis is a kind of irreversible pulmonary fibrosis induced by the long-term inhalation silica particles. The therapeutic strategy based on microRNAs might be an effective way for treatment silicosis. Our previous miRNA microarray data indicated that miR-326 was decreased in mouse lung tissues silica-induced fibrosis. However, specific functions remain unclear. objective to determine expression and biological effects Methods included models intervention were established separately explore...
Pulmonary fibrosis develops when myofibroblasts and extracellular matrix excessively accumulate in the injured lung, but what drives is not fully understood.Glycolysis has been linked to cell growth proliferation, several studies have shown enhanced glycolysis promotes pulmonary fibrosis.However, detailed describing this switch remain limited.Here, we identified that TGF-β1 effectively increased expression of circHIPK3 lung fibroblasts, inhibition attenuated activation, fibroblasts...
Silicosis is a very serious occupational disease and it features pathological manifestations of inflammatory infiltration, excessive proliferation fibroblasts massive depositions the extracellular matrix in lungs. Recent studies described roles variety microRNAs (miRNAs) fibrotic diseases. Here, we aimed to explore potential mechanism miR-542-5p activation lung fibroblasts. To induce pulmonary fibrosis mouse model, silica suspension agomir were administered mice by intratracheal instillation...
Abstract Dysregulation of non‐coding RNAs (ncRNAs) has been proved to play pivotal roles in epithelial‐mesenchymal transition (EMT) and fibrosis. We have previously demonstrated the crucial function long RNA (lncRNA) ATB silica‐induced pulmonary fibrosis‐related EMT progression. However, underlying molecular mechanism not fully elucidated. Here, we verified miR‐29b‐2‐5p miR‐34c‐3p as two vital downstream targets lncRNA‐ATB. As opposed lncRNA‐ATB, a significant reduction both was observed...
Background Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a condition characterised by the simultaneous presence of features both asthma and COPD. The study aims to investigate association between ACO frailty among middle-aged elderly populations, identify risk factors for in individuals with ACO. Methods We conducted cross-sectional 34 403 eligible participants (aged ≥40 years) from National Health Nutrition Examination Survey 1999–2018 cycles. Participants were...
Silicosis is a devastating interstitial lung disease arising from long-term exposure to inhalable silica. Regrettably, no therapy currently can effectively reverse the silica-induced fibrotic lesion. Emerging evidence has indicated that dysregulation of microRNAs involved in pulmonary fibrosis. The aim this study explore expression pattern and underlying mechanisms miR-770–5p Consistent with our previous miRNA microarray analysis, results qRT-PCR showed was downregulated fibrosis humans...
2519 Background: CLDN18.2 expression has been observed in various solid tumors especially gastric cancer, indicating its potential as a novel target for anti-tumor therapy. IBI389 is an anti-CLDN18.2/CD3 bispecific antibody that induces immune synapse formations by linking CD3 molecules T-cell receptor complexes and antigens on the membrane of tumor cells. Herein, we report preliminary results from phase I study to evaluate safety efficacy patients (pts) with advanced tumors. Methods:...
Silicosis is associated with fibroblast proliferation and extracellular matrix deposition in lung tissues. The dysregulation of miR-1224-5p has been implicated several human cancers; however, the expression function silicosis unknown. mitochondrial dysfunctions play critical roles some diseases, but how these processes are regulated remains limited. Here, we explored role a mouse model silicosis. We showed that increased both tissues silica-induced pulmonary fibrosis fibroblasts exposed to...
It is little known about the lncRNA-PVT1 effect on occupational pulmonary fibrosis, although researches show it plays an essential role in cancer. Studies reveal that lung fibroblast activation one of key events silica-induced fibrosis. Here, we found promoted proliferation, activation, and migration fibroblasts. The isolation cytoplasmic nuclear RNA assay fluorescence situ hybridization experiment showed was abundantly expressed cytoplasm. Luciferase reporter gene pull-down indicated...
Perimenopause symptoms have an extremely high incidence in aging women. Development of new strategies to improve perimenopause is important topic clinical context. Increasing studies shown that the polysaccharides Fructus corni (PFC) many pharmacological activities including antiaging effects. Here, we evaluated effects PFC on ovarian function natural aging-associated mice.Natural mice (16-month old) were orally administrated with at 1.11 g/kg daily for 24 days none-treated young (3-month as...
Wnt4 signaling is critical for mammalian female sex determination, in reproductive organ development, follicular and oocyte maturation, steroid hormone production. When function impaired, embryos undergo partial to male sex-reversal. This phenotype associated with the expression of a set somatic genes that are typical differentiation pathways such as those Leydig cells. Given roles 3`untranslated region (