A5101962961- Chromatography in Natural Products
- Plant-based Medicinal Research
- Natural product bioactivities and synthesis
- Traditional Chinese Medicine Analysis
- Computational Drug Discovery Methods
- Berberine and alkaloids research
- Protein Kinase Regulation and GTPase Signaling
- Nephrotoxicity and Medicinal Plants
- Analytical Chemistry and Chromatography
- Phytochemistry and Biological Activities
- Phytochemistry and biological activity of medicinal plants
- Fungal Biology and Applications
- Cell death mechanisms and regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Phytochemical Studies and Bioactivities
- Bioactive Compounds and Antitumor Agents
- Paraquat toxicity studies and treatments
- Synthesis and Biological Activity
- Sesquiterpenes and Asteraceae Studies
- Neurological Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- Heavy Metals in Plants
- Pain Mechanisms and Treatments
- Ion Channels and Receptors
Chinese Academy of Agricultural Sciences
2024-2025
Northwest A&F University
2025
Guangxi Buffalo Research Institute
2024-2025
National Synchrotron Radiation Laboratory
2025
University of Science and Technology of China
2025
Nanjing University of Chinese Medicine
2012-2024
University of Illinois Chicago
2023
Hebei Agricultural University
2023
Shandong University
2023
Southwest Hospital
2015
Background: Colostrum, abundant in immunoglobulins and growth factors, plays a vital role supporting immunity. Both yak buffalo milk are characterized by their high protein fat content. However, the metabolomic profiles of colostrum (YC), (BC), bovine (CC) remain largely unexplored. The objective this study is to identify unique metabolites that may impact nutritional value colostrum. Methods: This employed ultra-high performance liquid chromatography-electrospray ionization tandem mass...
Treating cerebral ischemia continues to be a clinical challenge. Studies have shown that the neurovascular unit (NVU), as central structural basis, plays key role in ischemia. Here, we report anthocyanin, safe and natural antioxidant, could inhibit apoptosis inflammation protect NVU rats impaired by middle artery occlusion/reperfusion (MCAO/R). Administration of anthocyanin significantly reduced infarct volume neurological scores MCAO/R rats. Anthocyanin also markedly ameliorate edema reduce...
Abstract Lipids play pivotal roles in supplying energy and promoting gut health. While yak buffalo milk are known for their high nutritional values, the lipid compositions of colostrum (YC) (BC) remain poorly explored. Here, untargeted lipidomics were applied to analyze YC, BC, cow (CC). 546, 353, 417 differential lipids identified comparisons YC-CC, BC-CC, YC-BC, respectively. Compared CC, YC exhibited a higher content C18:2, while BC was marked by lower levels saturated fatty acids....
Colostrum is a nutrient-dense food rich in proteins, immune modulators, and growth factors essential for neonatal development. Its lipids serve as key energy source facilitate cellular functions. While yak colostrum (YC) buffalo (BC) exhibit high nutritional value, their lipid compositions remain unclear. This study employed lipidomics to analyze compare the profiles of YC BC with cow (CC), identifying 872 across 33 subclasses. Differential analysis revealed 137, 100, 131 lipids, significant...
Pimprinine-type indolyloxazole alkaloids (PIAs), originally discovered in Streptomyces, show a diverse range of important pharmaceutical and agricultural bioactivities, yet their biosynthesis remains unknown. Herein, we report the identification biosynthetic enzymes responsible for formation structure PIAs from rhizosphere-derived Streptomyces netropsis NZY3, which involves three key enzymes, PimA (GCN5-related N-acetyltransferase, GNAT), PimB (pyridoxal 5'-phosphate-dependent tryptophan...
Both chronic obstructive pulmonary disease (COPD) and asthma are severe respiratory diseases. Bitter receptor–mediated bronchodilation is a potential therapy for asthma, but the mechanism underlying agonistic relaxation of airway smooth muscle (ASM) not well defined. By exploring ASM bitter substances, we observed that pretreatment with substances nearly abolished methacholine (MCh)-induced increase in cell (ASMC) calcium concentration, thereby suppressing calcium-induced contraction...
A new chemical component, cis-Z,Z'-3a.7a',7a.3a'-dihydroxyligustilide, was isolated from Angelica sinensis and its structure elucidated NMR MS spectra confirmed by X-ray single crystal diffraction analysis. We also explored the antioxidative properties of cis-Z,Z'-3a.7a',7a.3a'-dihydroxyligustilide on human umbilical vein endothelial cells (HUVECs) against injuries induced hydrogen peroxide (H2O2) using an MTT assay flow cytometry In addition, activities superoxide dismutase (SOD),...
<b><i>Objective:</i></b> We aimed to investigate the role of mShox2 in generating I<sub>f</sub> pacemaker current vitro by means electric-pulse stimulation (EPCS) canine mesenchymal stem cells (cMSCs). <b><i>Methods:</i></b> genetically modified cMSCs were prepared with pLentis-mShox2 red fluorescent protein. After EPCS induction, we examined kinetic characteristics generated inward a patch clamp. then evaluated expression...
Rho-kinase 1 (ROCK1) is a key molecular target for controlling smooth muscle (SM) contraction in asthma, gastrointestinal disorders, hypertension. Embryos of lotus seed (Nelumbo nucifera) are traditional folk herbs widely used treating various diseases which closely related to SM contraction. With the aim explaining mechanism embryos seed, 27 isoquinoline alkaloids were isolated from inhibitory activity these against ROCK1 virtual screened via docking and dynamics (MD) simulations. The...