A5021658288- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Gut microbiota and health
- Natural product bioactivities and synthesis
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Natural Compounds
- Analytical Chemistry and Chromatography
- Pharmacogenetics and Drug Metabolism
- Plant chemical constituents analysis
- Phytochemistry and Biological Activities
- Ideological and Political Education
- Bioactive Compounds and Antitumor Agents
- Estrogen and related hormone effects
- Synthesis and biological activity
- Phytochemistry and biological activity of medicinal plants
- Chromatography in Natural Products
- Traditional Chinese Medicine Studies
- Computational Drug Discovery Methods
- Plant-based Medicinal Research
- Drug Transport and Resistance Mechanisms
- PARP inhibition in cancer therapy
- Lignin and Wood Chemistry
- Berberine and alkaloids research
- Sesquiterpenes and Asteraceae Studies
- Psoriasis: Treatment and Pathogenesis
Wuxi People's Hospital
2020-2025
Nanjing Medical University
2020-2025
Nanjing Agricultural University
2020-2025
University of Macau
2016-2025
Tianjin University of Science and Technology
2025
Huaiyin Institute of Technology
2025
Hangzhou Medical College
2025
Zhejiang Provincial People's Hospital
2025
Xi'an Jiaotong University
2024
Zhejiang University
2024
Abstract Oral decoctions of traditional Chinese medicines (TCMs) serve for therapeutic and prophylactic management diseases centuries. Small molecules polysaccharides are the dominant chemicals co-occurred in TCM decoction. well-studied by multidisciplinary elaborations, whereas role remains largely elusive. Here we explore a gut microbiota-involved mechanism which restore homeostasis microbiota consequently promote systemic exposure concomitant small As case study, ginseng ginsenosides...
A stable and reproducible experimental bacterial pneumonia model postintracerebral hemorrhage (ICH) is necessary to help investigating the pathogenesis novel treatments of Stroke-associated (SAP). To establish a Gram-negative pneumonia-complicating ICH rat an acute lung injury (ALI)-complicating model. We established two standardized models post-ICH by nasal inoculation with Klebsiella pneumoniae (Kp) or intratracheal lipopolysaccharide (LPS). Survival neurological scores were monitored....
Ligustilide is the most abundant bioactive ingredient in Rhizoma Chuanxiong, a Chinese medicinal herb commonly used for treatment of cardiovascular ailments. The present study reported, first time, pharmacokinetics ligustilide, administered its pure form and an herbal extract, rats. After i.v. administration it was distributed extensively (V<sub>d</sub>, 3.76 ± 1.23 l/kg) eliminated rapidly (<i>t</i><sub>1/2</sub>, 0.31 0.12 h). clearance (CL) ligustilide after Chuanxiong extract...
Microctis Folium, the leaves of Microcos paniculata L., is a commonly used herbal tea material. The methanol extract Folium and its principle compounds vitexin (1), isovitexin (2) isorhamnetin 3-O-β-D-rutinoside (3) were investigated for their α-glucosidase inhibitory effects. showed strong effect (IC50 = 61.30 μg/mL) three flavonoid glycosides 1–3 exerted satisfactory effects, with IC50 values 244.0 μM, 266.2 μM 275.4 respectively. A simple reliable HPLC-DAD method was developed...
An on-line high performance liquid chromatography (HPLC)-diode array detector (DAD)-mass spectrometry (MS) analytical method has been developed to simultaneously separate and identify seventeen main constituents of Chuanxiong (Ligusticum chuanxiong Hort.), a traditional Chinese medicinal herb. In three samples, nine compounds were unequivocally determined as vanillin (1), ferulic acid (2), senkyunolide I (4), H (5), A (6), coniferyl ferulate (7), Z-ligustilide (8), neocnidilide (9)...
In this work, new lignin-based flame retardant LHDs were successfully synthesized through the reaction between lignin, 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) and hexamethylene diisocyanate (HDI). The chemical structure of LHD was characterized by FTIR, 1H NMR, 31P NMR. thermal stability studied TGA. results showed that residual carbon content L15HD (15% lignin in LHD) at 600 °C reached 16.55%, indicating prepared can be a type good char forming agent. then applied to...
Cyclodextrin (CD) complexation is widely used for the solubilization of poorly soluble drugs in pharmaceutical industry. Current research was to develop a highly lutein–cyclodextrin multiple-component delivery system (lutein–CD-MCDS) by combined modeling and experimental approaches. Both phase solubility diagram molecular dynamics (MD) simulation results revealed that interactions between lutein CDs were very weak, which confirmed insignificant improvement lutein–CD binary system. On basis...
As a main and characteristic constituent in Radix notoginseng, the fate of notoginsenoside R1 (NGR1) human is largely unknown. The present study investigated, for first time, NGR1 metabolism by intestinal bacteria liver subcellular fractions, permeability properties resultant metabolites on Caco-2 model. Samples were qualitatively analyzed using HPLC−MS/MS quantitatively determined HPLC−UV. When incubated with pooled anaerobically, showed biphasic elimination: an insignificant decrease 8 h...
ABSTRACT A sensitive and specific LC‐MS/MS method was developed for simultaneous determination of aloe‐emodin, rhein, emodin, chrysophanol physcion their conjugates in rat plasma. The lower limit quantitation each anthraquinone 0.020–0.040 µ m . Intra‐day inter‐day accuracies were 90.1–114.3% the precisions <14.6%. matrix effects 104.0–113.2%. successfully applied to a pharmacokinetic study rats receiving rhubarb extract orally. area under concentration–time curve (AUC 0– t ) peak...