A5100756249- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Hepatitis B Virus Studies
- Epigenetics and DNA Methylation
- Bioactive Compounds and Antitumor Agents
- Alzheimer's disease research and treatments
- Synthesis and Biological Evaluation
- Liver Disease and Transplantation
- Virus-based gene therapy research
- HIV Research and Treatment
- Genomics, phytochemicals, and oxidative stress
- Cancer, Hypoxia, and Metabolism
- Hepatitis C virus research
- Chromatography in Natural Products
- Natural product bioactivities and synthesis
- Histone Deacetylase Inhibitors Research
- Autophagy in Disease and Therapy
- Liver physiology and pathology
- Traditional Chinese Medicine Analysis
- Synthesis of Indole Derivatives
- Inflammation biomarkers and pathways
Jiangsu Province Hospital
2023-2025
Chengdu University of Traditional Chinese Medicine
2022-2025
Nanjing University of Chinese Medicine
2017-2025
Union Hospital
2024
Huazhong University of Science and Technology
2024
Bengbu Medical College
2022-2024
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2024
Binzhou University
2024
Binzhou Medical University
2024
Henan Cancer Hospital
2023
Parkinson's disease (PD) is the second most common neurodegenera-tive disorder after Alzheimer accompanied by death of dopaminergic neurons and brain nigrostriatal mitochondrial damage in elderly population. The features include tremor, rigidity, postural instability, motor retardation. pathogenesis complex, abnormal lipid metabolism resulting ferroptosis due to excessive accumulation free radicals from oxidative stress substantia nigra was thought be one factors causing disease. Morroniside...
Shikonin(SK) is a natural small molecule naphthoquinone compound, which has anti-cancer activity in various human malignant tumors. Pyrroline-5-carboxylate reductase 1(PYCR1) involved tumorigenesis and regulates cellular processes, including growth, invasion, migration, apoptosis. However, the effect of SK PYCR1 on apoptosis autophagy hepatocellular carcinoma are unclear. Our goal to determine internal molecular mechanism interaction between its role occurrence development liver cancer. The...
The application of immunotherapy in tumor, especially immune checkpoint inhibitors (ICIs), has played an important role the treatment advanced unresectable liver cancer. However, efficacy ICIs varies greatly among different patients, which aroused people’s attention to regulatory mechanism programmed death ligand-1 (PD-L1) escape PD-L1 is regulated by multiple levels and signaling pathways hepatocellular carcinoma (HCC), including gene variation, epigenetic inheritance, transcriptional...
// Sojan Abraham 1 , Jang-Gi Choi 1,2 Nora M. Ortega Junli Zhang Premlata Shankar and N. Manjunath Swamy Center of Emphasis in Infectious Disease, Department Biomedical Sciences, Paul L. Foster School Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA 2 KM Application Korea Institute Oriental Dong-gu, Daegu, Republic Correspondence to: Swamy, email: Keywords : interferon, HIV-1, hydrodynamic injection, Immunology Microbiology Section, Immune response, Immunity Received...
Background While the tumor microenvironment (TME) affects immune checkpoint blockade (ICB) efficacy, ICB also reshapes characteristics of TME. Thus far, studies have focused on TME evolution during neoadjuvant or adjuvant therapy in gastric cancer (GC). However, interaction between and immunotherapy plus chemotherapy remains to be elucidated. Methods We performed single-cell RNA sequencing ten GC specimens pre- post-neoadjuvant camrelizumab mFOLFOX6 determine impact efficacy combination...
Nonalcoholic fatty liver disease (NAFLD) is the most common in world. NAFLD has become one of major factors contributing to hepatocellular carcinoma (HCC) development. However, there are no clear targets and therapeutic drugs for NAFLD-related cancer. This study explored active compounds, target mechanism coptidis rhizoma evodiae fructus treatment cancer based on network pharmacology experimental verification. There were 455 intersection cancer, 65 drug-disease targets. AKT1 highest degree,...
Purpose: To prepare and characterize transdermal films of diclofenac diethanolamine as a safer more effective alternative than the sustained release (SR) tablet equivalent for prolonged relief from pain inflammation in arthritis.Methods: Transdermal were prepared using sodium carboxymethyl cellulose polyvinyl pyrrolidone K30, with turpentine oil sesame penetration enhancers. The characterized physicochemical properties ex vivo permeation randomized clinical trial(RCT) analgesic activities...
Purpose: This study aimed to investigate the improvement effect of Sini Decoction plus Ginseng Soup (SNRS) on LPS/D-GalN-induced acute liver failure (ALF) mouse model and molecular mechanism SNRS effect. Methods: To protective ALF mice, ICR mice were firstly divided into 4 groups: Control group (vehicle-treated), Model (LPS/D-GalN), (LPS/D-GalN+SNRS), Silymarin (LPS/D-GalN+Silymarin), therapeutic drug was administered by gavage 48h, 24h before, 10 min after LPS/D-GalN injection. On this...
Attempts at eliciting neutralizing antibodies against human immunodeficiency virus (HIV)-1 have generally failed. Computationally designed epitope-scaffold platforms allow transplantation of structural epitopes to scaffold proteins. Human rhinovirus (HRV) allows such engrafting HIV-1 on the surface However, since HRV infects only humans and great apes, efficacy chimeric HRV-based live viral vaccines is difficult assess in animal models. Here, we used ICAM-1 transgenic (hICAM-1 Tg) mice that...
With the widespread of colonoscopy, colorectal cancer remains to be one most detrimental types cancer. Though there were multiple studies investigating genomic landscape cancer, a comprehensive analysis uncovering differences between various is still lacking. In our study, we performed on 133 patients with Mutated FAT1 and PKHD1 altered Hippo pathway genes found enriched in early-onset APOBEC signature was prevalent microsatellite stable (MSS) related lymph node metastasis. ZNF217 mutations...
ABSTRACT Colorectal cancer (CRC) is a highly malignant tumor with hypoxia being crucial feature during its progression. This study utilized multiple independent CRC cohorts for bioinformatics analysis and in vitro experiments to investigate the role of hypoxia‐related subgroups CRC. Machine learning was employed construct risk features associated this subgroup further explore therapeutic value The identified GPNMB+ Macrophage (GPNMB+ Macr) as most relevant hypoxia. Macr showed significantly...
Severe liver fibrosis may be accompanied by intestinal barrier damage, such as bacterial peritonitis, suggesting that the role of gut-liver axis is nonnegligible. Dachengqi decoction (DCQD) was reported to improve bowel movements, but whether DCQD effective for damage caused remained unclear. To investigate in fibrosis-related gut vascular (GVB) mice. verified reduce imbalance and restore homeostasis prove acts through axis. Three graded doses were gavaged into CCL4-induced mice 12 weeks...
Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer accompanied by death of dopaminergic neurons and brain nigrostriatal mitochondrial damage in elderly population. The features include tremor, rigidity, postural instability, motor retardation. pathogenesis complex, abnormal lipid metabolism resulting ferroptosis due to excessive accumulation free radicals from oxidative stress substantia nigra was thought be one factors causing disease....