A5002936169- Cell Adhesion Molecules Research
- HER2/EGFR in Cancer Research
- Biomedical Text Mining and Ontologies
- Congenital Heart Disease Studies
- Electronic Health Records Systems
- Health Literacy and Information Accessibility
- Complementary and Alternative Medicine Studies
- Monoclonal and Polyclonal Antibodies Research
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Peptidase Inhibition and Analysis
- NF-κB Signaling Pathways
- Cardiovascular Issues in Pregnancy
- Patient-Provider Communication in Healthcare
- Chronic Disease Management Strategies
- Tactile and Sensory Interactions
- Hedgehog Signaling Pathway Studies
- Digital Imaging in Medicine
- Acupuncture Treatment Research Studies
- Protein Degradation and Inhibitors
- Cardiac Health and Mental Health
- Pharmaceutical Practices and Patient Outcomes
- Genomics and Chromatin Dynamics
- Clinical practice guidelines implementation
- Visual and Cognitive Learning Processes
University of Utah
2001-2023
Primary Children's Hospital
2020
VA Salt Lake City Healthcare System
2006-2016
Corvallis Environmental Center
2012
Huntsman Cancer Institute
2003-2006
Conditional deletion of beta1 integrins in the intestinal epithelium, unlike epidermal and mammary epithelia, mice does not result decreased cell adhesion proliferation, but instead causes a profound increase epithelial proliferation with dysplasia polypoid structures. The increased inhibited differentiation that caused severe malnutrition early postnatal lethality. striking similarities between integrin-deleted neonatal defective Hedgehog signaling led to discovery expression was markedly...
Abstract Objectives First, to evaluate the effect of standard vs pictograph-enhanced discharge instructions on patients’ immediate and delayed recall satisfaction with their instructions. Second, automated pictograph enhancement patient Materials Methods Glyph, an healthcare informatics system, was used automatically enhance pictographs. Glyph developed at University Utah by our research team. Patients in a cardiovascular medical unit were randomized receive or Measures compared between two...
Because HER-2 has been demonstrated in the nuclei of cancer cells, we hypothesized that it might interact with transcription factors activate ERBB2 transcription. Macrohistone 2A1 (H2AFY; mH2A1) was found to cells overexpress HER-2. Of two human mH2A1 isoforms, mH2A1.2, but not mH2A1.1, interacted cell lines. Overexpression significantly increased expression and tumorigenicity. Inhibition kinase activity diminished mH2A1.2-induced cells. Chromatin immunoprecipitation mH2A1.2 stably...
We developed a novel computer application called Glyph that automatically converts text to sets of illustrations using natural language processing and graphics techniques provide high quality pictographs for health communication. In this study, we evaluated the ability system illustrate set actual patient instructions, tested recall original illustrated instructions.We used 49 instructions representing 10 different discharge templates from University Utah Cardiology Service. 84 participants...
HER-2 is constitutively activated and overexpressed in many cancers, its inhibition colon cancer cells diminishes tumorigenicity induces apoptosis. Little known about the regulation of signaling cells. Integrin α5/β1 expression frequently lost colorectal compared with normal intestinal epithelium, lacking integrin utilize for proliferation tumorigenicity. Re-expression abrogated their tumorigenicity, but how this occurs not well known. Stable little or no detectable protein resulted...
Abstract Little information is available as to the potential role of HER‐2 a therapeutic target in colon cancers, which express much fewer receptors than breast cancer cells. Treatment certain human cell lines with inhibitory antibody mAb 4D5 demonstrated for mediating proliferation, apoptosis and tumorigenicity. However, only that were dependent on autocrine EGFR‐mediated proliferation susceptible antiproliferative antitumorigenic effects inhibition. The relative levels HER‐2, EGFR, HER‐3...
Background: Compared to traditional methods of participant recruitment, online crowdsourcing platforms provide a fast and low-cost alternative. Amazon Mechanical Turk (MTurk) is large well-known service. It has developed into the leading platform for recruitment. Objective: To explore application health informatics research, specifically testing medical pictographs. Methods: A set pictographs created cardiovascular hospital discharge instructions was tested recognition. This illustrations...
While complementary and alternative medicine (CAM) is commonly used in the United States elsewhere, hazardous interactions with prescription drugs can occur, patients do not regularly communicate physicians about their CAM use. The objective of this study was to discover patient information needs preferences for herb-drug-disease interaction alerts. We recruited 50 people from several locations within University Utah Hospital participate structured interview study. They were asked provide...
Abstract Background: A 10% prevalence of intracranial aneurysms in patients with coarctation the aorta has been described a few studies. Our objective is to describe rate aneurysm detection current era. We hypothesise that, earlier and intervention, lower than previously reported screening imaging may only be warranted older or certain risk factors. Methods: This retrospective study 102 aged 13 years who underwent brain computed tomography angiography, magnetic resonance (MRI), angiography...
Introduction: Several studies have reported that illustrations may improve patient comprehension of health communications. However, developing effective remains a challenge. To discharge instructions with illustrations, we developed computer application (Glyph) automatically converts text to pictures using natural language processing and graphics techniques.Methods: We evaluated set pictographs created for cardiovascular through recognition testing, examined illustration approaches work...
Page 19027, Introduction: The following sentence should have been deleted from the manuscript (right column, in last paragraph of Introduction): “In addition, stable expression integrin α5/β1 a colon cancer cell line resulted significant decrease amphiregulin mRNA levels and loss constitutive EGFR autophosphorylation, which was seen control cells.” This error does not change any conclusions published work.