A5079787466- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Analog and Mixed-Signal Circuit Design
- Power Systems and Technologies
- CCD and CMOS Imaging Sensors
- Fire dynamics and safety research
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Cloud Computing and Resource Management
- CAR-T cell therapy research
- interferon and immune responses
- Energetic Materials and Combustion
- Cancer Immunotherapy and Biomarkers
- Autophagy in Disease and Therapy
- Combustion and Detonation Processes
- Smart Grid and Power Systems
- Metabolism, Diabetes, and Cancer
- Venous Thromboembolism Diagnosis and Management
- Graph Theory and Algorithms
- Cytokine Signaling Pathways and Interactions
- Radio Frequency Integrated Circuit Design
- Nonlocal and gradient elasticity in micro/nano structures
- Media Influence and Politics
- Security and Verification in Computing
Qinghai University
2022-2025
Peking University
2025
Tsinghua University
2024
Changsha University of Science and Technology
2024
Center for Rheumatology
2024
Nanchang University
2024
Nanjing Audit University
2024
Zhejiang University
2024
China Agricultural University
2023
Affiliated Hospital of Nantong University
2023
Microplastics (MPs) as emerging contaminants have become a global environmental problem. However, studies on the effects of MPs metabolic diseases remain limited. Here, we evaluated polystyrene (PS), one most prominent types MPs, insulin sensitivity in mice fed with normal chow diet (NCD) or high-fat (HFD), and explained underlying mechanisms. Mice NCD HFD both showed resistance (IR) after PS exposure accompanied by increased plasma lipopolysaccharide pro-inflammatory cytokines such tumor...
The aorta and the large conductive arteries are immunoprivileged tissues protected against inflammatory attack. A breakdown of immunoprivilege leads to autoimmune vasculitis, such as giant cell arteritis, in which CD8+ Treg cells fail contain CD4+ T macrophages, resulting formation tissue-destructive granulomatous lesions. Here, we report that molecular defect malfunctioning lies aberrant NOTCH4 signaling deviates endosomal trafficking minimizes exosome production. By transcriptionally...
Phytoplankton biomass is generally measured as chlorophyll-a concentration (Chla), and well known to be sensitive nutrients large zooplankton. However, whether nutrient was still a better predictor of Chla when potential affecting variables were taken together, the critical TN:TP (total nitrogen: total phosphorus, by mass) threshold for classifying limitation varied with lake type remain uncertain. Furthermore, it remains largely unknown what extent small zooplankton (SZ) can affect...
Carbon storage is a critical ecosystem service provided by terrestrial environmental systems that can effectively reduce regional carbon emissions and for achieving neutrality peak. We conducted study in Kunming analyzed the land utilization data 2000, 2010, 2020. assessed features of conversion forecasted under three development patterns 2030 on basis Patch-generating Land Use Simulation (PLUS) model. used Integrated Valuation Ecosystem Services Trade-offs (InVEST) model to estimate changes...
In the field of materials science, addressing complex relationship between material structure and properties has increasingly involved leveraging text generation capabilities AI-generated content (AIGC) models for tasks that include literature mining data analysis. However, theoretical calculations code development remain labor-intensive challenges. This paper proposes a novel approach based on text-to-code generation, utilizing large language to automate implementation simulation programs...
Fungi infestation as a disease has serious impacts on the cultivation of Morchella species. To investigate effects fungi microbial diversity and community structure soil when cultivating sextelata, we sampled samples cultivars in Qinghai–Xizang Platea used metagenome sequencing technology to identify analyze differences between disease-infested healthy soils. The identified were Tricharina gilva Peziza lohjaoensis, T. gilva-infected was higher than that soil, while P. lohjaoensis-infected...
Patients with primary brain abscess often present atypical symptoms, and the outcome varies. We investigated demographic, laboratory, neuroimaging features of patients at our hospital identified factors associated their outcomes.We retrospectively collected data diagnosed between January 2011 December 2020. Their clinical characteristics, predisposing factors, laboratory findings, treatment, were analyzed.Of 57 abscess, 51 (89.47%) older than 40 years, 42 (73.68%) male. Only eight (14.04%)...
Abstract Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are relatively common autoimmune diseases, often considered prototypic examples for how protective immunity switches to destructive immunity. The autoantigens recognized in RA SLE distinct, clinical manifestations partially overlapping. A shared feature is the propensity of adaptive immune system respond inappropriately, with T cell hyper-responsiveness a pinnacle pathogenic defect. Upon antigen recognition, cells...
The human adult immune system maintains normal T cell counts and compensates for loss throughout life, mainly through peripheral homeostatic proliferation after the ability of thymus to generate new cells has rapidly declined at adolescence. This process is driven by STAT5-activating cytokines, most importantly IL-7, very effective in maintaining a large naive CD4+ compartment into older age. Here, we describe that undergo adaptations optimize IL-7 responses upregulating guanine-nucleotide...
Both controllable regulation of the conformational structure a polypeptide and specific recognition an amino acid are still arduous challenges. Here, novel dual-mode (electrochemical colorimetric) biosensor was built for arginine (Arg) based on conformation switch, utilizing synergistic self-assembly ferrocene-grafted hexadecapeptide (P16Fc) with gold nanoparticles (AuNPs). Benefiting from flexibility unique topological P16Fc formed nanospheres, assembly disassembly can undergo transition...
Mitochondria are the controllers of cell metabolism and recognized as decision makers in death pathways, organizers cytoplasmic signaling networks, managers cellular stress responses, regulators nuclear gene expression. Cells immune system particularly dependent on mitochondrial resources, they must swiftly respond to danger signals with activation, trafficking, migration, generation daughter cells. Analogously, faulty responses that lead autoimmunity tissue inflammation rely mitochondria...
Today, the sorting of battery packs and pouch cells from waste electrical electronic equipment (WEEE) is performed manually as batteries vary in shape weight. Therefore, feasibility to classify by first recognizing text on an image with deep learning object character recognition (OCR), then comparing extracted a database known information representing types investigated. In addition, sort beyond what viable today evaluated examining IEC code lithium-ion (LIBs) cathode material. Results are...
<p>Intrahepatic cholangiocarcinoma (ICC) is a rare hepatobiliary cancer that originates from the epithelium of intrahepatic bile duct. The various treatments for ICC, such as chemotherapy, radiotherapy, and locoregional therapy, confer only modest improvements in survival rates. Immunotherapy, although revolutionary treatment, has found limited application treatment ICCs due to “cold” nature these tumors, which marked by scant T-cell infiltration. This characteristic makes immune...